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348 results about "Methylpyridinium" patented technology

Methylpyridinium is a chemical compound which is the quaternary ammonium compound derived from the N-methylation of pyridine. It is found in some coffee products. It is not present in unroasted coffee beans, but is formed during roasting from its precursor chemical, trigonelline. It is under investigation by scientists regarding its potential anti-carcinogenic properties, particularly an effect on colon cancer.

Compositions for treating CNS disorders

An aminomethylpyridyloxymethyl / benzisoxazole substituted azabicyclic compound, a pharmaceutical composition comprising same, and a method of treating one or more CNS or other disorders, including concurrent treatment of disorders such as schizophrenia and depression.
Owner:PFIZER INC

Process for synthesizing imatinib

The invention discloses a method for synthesizing imatinib. The method comprises that: N-(4-methyl-3-3-aminophenyl)-4-(4-methyl-piperazinyl-1-methyl)-benzamide is used as a raw material, and reacts with 4-methyl-(3-pyridyl)-2-pyrimidone under actions of a polypeptide condensation agent and an organic alkali so as to generate the imatinib. The method has the advantages of mild reaction conditions, easy operation, high reaction yield and suitability for industrialized production.
Owner:FUJIAN SOUTH PHARMA CO LTD

MFI structure molecular sieve containing phosphorus and transition metal as well as its preparation method

The invention relates to a MFI structure molecular sieve containing phosphorus and transition metal as well as its preparation method. The anhydrous chemical expression of the molecular sieve is (0-0.3) Na2O.(0.5-6) Al2O3.(1.3-10) P2O5.(0.7-15) MxOy.(70-97) SiO2, wherein M is selected from one or more of Fe, Co, Ni, Cu, Mn, Zn, Sn and Bi, x is expressed as atomicity of M, y is expressed as a number which satisfies the requirement of an oxidation state of M; No characteristic absorption peak is existed at 1633cm<-1> on infrared spectrum by molecular sieve trimethylpyridine adsorption. The preparation method comprises that phosphor and transition metal are introduced in molecular sieve with the MFI structure during ammonium exchanging, wherein the phosphor introduction is divided into two parts, a part of phosphor is introduced before introducing the transition metal or at the same time with transition metal introduction, the other part of the phosphor is introduced after the transitionmetal introduction. The provided molecular sieve is used for conversing hydrocarbon oil, the yield of dry gas and coke is low, and the yield of propylene and isobutene is high.
Owner:CHINA PETROLEUM & CHEM CORP

Catalyst for producing 3-cyano pyridine as well as preparation method and use thereof

The invention relates to a catalyst for producing 3-cyanopyridine and a preparation method and application thereof. Aiming at that the prior catalyst for producing the 3-cyanopyridine by ammoxidizing 3-methylpyridine has the disadvantages of higher service temperature and large energy consumption, the invention provides a catalyst which has low service temperature and small energy consumption and is used for producing the 3-cyanopyridine by ammoxidizing the 3-methylpyridine, and a preparation method and application thereof. A carrier of the catalyst adopts anatase TiO2, an active constituent adopts V2O5, and an auxiliary agent adopts one or more than one of transition metal oxide or alkali metal oxide; the method for preparing the catalyst comprises the following steps: the carrier, the active constituent and a predecessor of the auxiliary agent are weighed according to the mixture ratio, and are placed into an oxalic acid solution to be mixed evenly, the pH value of a mixed liquid is controlled, the mixed liquid is evaporated to obtain solid powder, and the solid powder is baked to obtain the catalyst. The catalyst is used for producing the 3-cyanopyridine by ammoxidizing the 3-pyridylamine in a gas phase.
Owner:ZHEJIANG NORMAL UNIVERSITY

Method for synthesizing esomeprazole sodium

The invention discloses a method for synthesizing esomeprazole sodium. The method comprises the steps as follows: preparing 5-methoxy-2-(4-methoxy-3,5-dimethyl-2-pyridyl) methylthio-1H-benzimidazole, namely prochirality thioether; preparing crude esomeprazole sodium; refining the crude esomeprazole sodium; adding the prepared prochirality thioether and dried methylbenzene into D-(-) diethyl tartrate and water by stirring, adding titanium isopropylate, and stirring; and adding diisopropylamine at constant temperature, stirring, dropwise adding cumyl hydroperoxide with the mass concentration of 80%, ending the reaction, extracting, salifying, concentrating, washing and carrying out vacuum drying to obtain a crude product, and refining the crude product to obtain the esomeprazole sodium. The method is low in cost, toxicity and pollution, easy to operate, short in reaction time, high in product purity and easy for industrial production.
Owner:KAMP PHARMA

Preparation and application of pyrazole oxime ether compound containing trifluoro methyl pyridine

The invention relates to preparation and application of a pyrazole oxime ether compound (I) containing trifluoro methyl pyridine. The pyrazole oxime ether compound is prepared by carrying out condensation on pyrazole-containing hydroxamic acid (II) and 2-(4-chloromethyl phenoxyl)-5-trifluoro methyl pyridine (III). The pyrazole oxime ether compound (I) containing trifluoro methyl pyridine has an effective controlling effect on harmful insects and can be used for preparing insecticides for the fields of agriculture, horticulture and the like. A general formula of the pyrazole oxime ether compound (I) is shown in the specification.
Owner:营口兴福化工有限公司

Pharmaceutical compositions of n-methyl-2-[3-((e)-2-pyridin-2-yl-vinyl)-1h-indazol-6-ylsulfanyl]-benzamide

The present invention relates to pharmaceutical compositions containing axitinib, which is known as N-methyl-2-[3-((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-ylsulfanyl]-benzamide or 6-[2-(methylcarbamoyl)phenylsulfanyl]-3-E-[2-(pyridin-2-yl)ethenyl]indazole, or crystalline forms thereof, that protect axitinib from degradation, including photodegradation, as well as the therapeutic use of such compositions. The present invention also relates to novel photodegradants of axitinib.
Owner:PFIZER INC

Mesoporous TiO2 supported V2O5 catalyst with high specific surface area as well as preparation method and use thereof

The invention relates to a mesoporous TiO2 supported V2O5 catalyst with high specific surface area and a preparation method and application thereof. Aiming at the disadvantages that the prior V2O5Tio2 has low catalytic activity, high reaction temperature, and poor selectivity and catalyst stability when 3-methylpyridine is ammoxidized to produce 3-cyanopyridine, the invention provides a mesoporous TiO2 supported V2O5 catalyst which has low reaction temperature, high transformation rate and good selectivity, is used for producing the 3-cyanopyridine by ammoxidizing the 3-methylpyridine and has high specific surface area, and a preparation method and application thereof. The catalyst comprises a carrier and an active constituent, the carrier adopts TiO2, and the active constituent adopts V2O5. The method for preparing the catalyst comprises the following steps: a template agent adopts organic amine, a titanium source adopts tetraisopropoxy titanium, a vanadium source adopts triisopropoxyvanadium oxide, and the TiO2 supported V2O5 catalyst is directly synthesized in a polytetrafluorine kettle under hydrothermal conditions. The catalyst is used for producing the 3-cyanopyridine by ammoxidizing the 3-methylpyridine in a gas phase.
Owner:ZHEJIANG NORMAL UNIVERSITY

Tetrafluoropropene composition with good lubricant compatibility and preparation method thereof

The invention discloses a tetrafluoropropene composition with good lubricant compatibility and a preparation method thereof. The compositions comprises, in parts by weight, 0.4-15 parts of fluorine-modified Ni-containing hydrotalcite-like compound, 0.002-0.25 part of a silane coupling agent, 49.5-985 parts of a lubricant, 4000-90000 parts of 2,3,3,3-tetrafluoropropene, 0-60000 parts of fluoroethane, 0-15000 parts of 1,1-difluoroethane, 0-5000 parts of isobutane, and 0.8-1 part of N-propyl-3-methylpyridinium bis(trifluoromethylsulfonyl)imide. The invention also provided a preparation method of the tetrafluoropropene composition. The tetrafluoropropene composition has god lubricant compatibility and flame retardation performance.
Owner:JUHUA GROUP TECH CENT

Preparation method for high-purity milrinone

The invention discloses a preparation method for high-purity milrinone (shown as a formula (I), 1,6-dihydro-2-methyl-6-oxo-3,4-bipyridine-5-carbonitrile), and belongs to the field of chemical medicines. The method comprises: employing 4-methylpyridine as a raw material and acetylating with acetyl chloride, and hydrolyzing after the reaction is finished, so as to obtain a compound of a formula (III); mixing the compound of the formula (III) with glacial acetic acid, acetic anhydride and triethyl orthoformate, and reacting at 35 DEG C-45 DEG C, so as to obtain a compound of a formula (IV); performing cyclization on the compound of the formula (IV) and alpha-cyanoacetamide, so as to obtain a crude product of a compound of the formula (I); and refining the crude product of the formula (I) compound through an ethanol-water system, so as to obtain a high-purity refined product with the maximum interplanar spacing d of 8.39 + / - 0.02 Angstrom. The technology is relatively mild in reaction conditions and relatively simple in operation, and is capable of preparing the milrinone product with high purity and a single crystal form. The obtained milrinone crystal form is relatively excellent in solubility in normal saline or glucose, and is beneficial for improvement of the preparation quality.
Owner:HUZHOU ZHANWANG PHARMA

2-ammonia methyl-pyridine nickel composition, preparation method and application thereof

InactiveCN101607934AInhibits chain transfer and chain terminationImprove linearityNickel organic compoundsKetoneChemistry
The invention discloses a 2-ammonia methyl-pyridine nickel composition, a preparation method and the application thereof. The composition has a structure of a formula I, wherein R1 stands for hydrogen or alkyl, R2 stands for hydrogen or alkyl, R3 stands for hydrogen or alkyl, and X stands for halogen. The preparation method of the composition comprises the following steps: (1) generating 2-pyridine imine compound through the ketone-ammonia condensation reaction of an aromatic ketone compound and 2,6-diisopropyl aniline; then, reacting with trimethylbenzene magnesium bromide, trimethylaluminium or lithium aluminum hydride to obtain 2-ammonia methyl-pyridine ligand; and (2) under a waterless and anoxic condition, obtaining a 2-ammonia methyl-pyridine nickel composition I by the complexation reaction of the 2-ammonia methyl-pyridine ligand III and (DME) NiX2. The 2-ammonia methyl-pyridine nickel composition has a specific ligand substitute structure, can catalyze ethylene to actively polymerize so as to obtain polyethylene with high molecular weight, narrow distribution and a certain branching degree.
Owner:SUN YAT SEN UNIV

Carbon-carbon double bond bridging covalent organic framework material and preparation method thereof

The invention discloses a carbon-carbon double bond bridged covalent organic framework material and a preparation method thereof, and relates to the field of covalent organic framework materials. According to the invention, N-alkyl-2, 4, 6-trimethylpyridine quaternary ammonium salt used as a core monomer and 2, 4, 6-tris(4-aldehyde phenyl)-1, 3, 5-triazine are used to synthesize the carbon-carbon double bond bridging covalent organic framework material through a heating reaction. The obtained covalent organic framework material has the advantages of high crystallinity, high specific surface area, regular open pore channel structure, rich photoelectric activity, good thermal stability and two-dimensional layered morphology.
Owner:SHANGHAI JIAO TONG UNIV

Oxosynthesis method of methylpyridine-1-oxide

The invention discloses an oxosynthesis method of methylpyridine-1-oxide, comprising two steps of preparation of a catalyst and oxidation reaction, wherein the preparation of the catalyst comprises the steps of after cleaning, high temperature boiling, drying and cooling pretreatment of activated carbon, adding into a phosphotungstic acid solution, stirring till complete soaking, and after ultrasonic treatment, evaporating to remove a solvent to obtain a phosphotungstic acid supported on active carbon catalyst; the oxidation reaction comprises the steps of mixing methylpyridine with the phosphotungstic acid supported on active carbon catalyst, stirring, adding hydrogen peroxide for reaction, and separating the phosphotungstic acid supported on active carbon catalyst to obtain methylpyridine-1-oxide filtrate being a methylpyridine-1-oxide crude product, and distilling under reduced pressure to obtain the product. When the method is used for preparing the catalyst, a carrier is cheap and convenient, a preparation process is simple, the catalyst in the oxidation reaction is less in use level, convenient to recycle, resuable and low in cost, product yield is up to 97%, product purity is up to 98% and productivity is more than 98%.
Owner:NANTONG ACETIC ACID CHEM

Preparation method of nanometer VN/graphene composite paste electrode sensor

The invention discloses a preparation method of a nanometer VN / graphene composite paste electrode sensor. The preparation method comprises following steps: firstly, sulfuric acid is adopted for pre-treatment of oxidized graphene so as to obtain pre-treated oxidized graphene; by mass, 42 to 45% of nanometer VN, 20 to 25% of the pre-treated oxidized graphene, 12 to 18% of N-ethyl-3-methylpyridine hexafluorophosphate, 8 to 12% of liquid paraffin, and 6 to 10% of petroleum ether are introduced into a agate mortar for uniform grinding, an obtained carbon paste is introduced into a glass tube connected with a wire, compressing, drying, polishing with abrasive paper for metallograph, polishing, and deionized water washing are carried out so as to obtain a nanometer VN / graphene composite paste electrode, wherein the internal diameter of the glass tube is 5mm. The electric conductivity of the nanometer VN / graphene composite paste electrode is increased by 2 to 4 times of that of common paste electrode; the electrochemical window is wide; the preparation method is simple; cost is low; surface replacing is convenient; residual current is low; the sensitivity and the selectivity in detection of luteolin are high.
Owner:UNIV OF JINAN

Method for preparing 5-bromo-2-methylpyridine

The invention discloses a method for preparing intermediate 5-bromo-2-methylpyridine. In the prior art, the dosage of aluminium trichloride is large; the catalytic effect is poor; the by-products are more; the yield of products is low; and the obtained products are difficult to separate. The method comprises the following steps: reacting diethyl malonate with alkali metal to generate salts, dripping 5-nitryl-2-chloropyridine into the salts for condensation reaction, and subsequently performing decarboxylation on the obtained product under acidic condition to obtain 5-nitryl-2-methylpyridine; performing hydrogenation reduction on the 5-nitryl-2-methylpyridine under the catalysis of Pd / C catalyst to obtain 5-amido-2-methylpyridine; and reacting the 5-amido-2-methylpyridine with acid to generate salts, dripping bromine, dripping a sodium nitrite water solution, and obtaining the 5-bromo-2-methylpyridine. The method has mild reaction conditions, easy operation, simple post-treatment, good catalytic effect, high yield of each step and high yield of final products, and is particularly suitable for industrialized production.
Owner:ZHEJIANG MEDICINE CO LTD XINCHANG PHAMACEUTICAL FACTORY

Method for preparing loofah sponge immobilized ionic liquid adsorbent

The invention discloses a method for preparing a loofah sponge immobilized ionic liquid adsorbent and application techniques of the adsorbent. The method is characterized by comprising the following steps: removing peels and kernels of a mature loofah fruit, washing by water to remove soil and impurities, drying, smashing, treating the smashed loofah sponge by sodium hydroxide and hydrogen peroxide, drying to obtain an oxidized loofah sponge, adding 62%-72% of epoxy chloropropane and 15%-28% of oxidized loofah sponge in percentage by mass into a reactor, stirring and reacting at the constant temperature of 70-80 DEG C for 40-60 minutes, cooling, adding 4%-10% of pyromellitic dianhydride and 2%-6% of N-ethyl-3methylpyridine bromate ionic liquid, stirring and reacting for 48-60 hours at the constant temperature of 33-37 DEG C, cooling, carrying out suction filtration, washing by deionized water till filtrate is neutral, washing by a little ethyl alcohol and drying in a vacuum drying oven at the temperature of 50 DEG C to obtain the loofah sponge immobilized ionic liquid adsorbent. The adsorbent has the advantages of very high arsenic adsorption capacity, excellent physicochemical and mechanical properties, strong regeneration capacity, high frequency of repeated use, low cost and environmental protection.
Owner:UNIV OF JINAN

Triazolopyrimidine sulfonamide compound, and synthetic method and application thereof

The invention provides a triazolopyrimidine sulfonamide compound and synthetic methods and application thereof, relating to a penoxsulam analog and a synthetic method and application thereof. The objective of the invention is to overcome the problems of great synthesis difficulty and high cost of conventional penoxsulam. The triazolopyrimidine sulfonamide compound has a structural formula described in the specification. The method 1 comprises the following steps: 1, preparing 2-methyl-3-chlorobenzenesulfonyl chloride; and 2 preparing a finished product so as to obtain 3-chloro-2-methyl-N-(5,8-dimethoxy-[1,2,4] triazolo[1,5-c]pyrimidine-2-yl) benzsulfamide. The method 2 comprises the following steps: 1, preparing 2-mercapto-3-trifluoromethylpyridine; and 2, preparing 3-trifluoromethylpyridine-2-sulfonyl chloride; and 3, preparing a finished product so as to obtain 3-trifluoro-methyl-N-(5,8-dimethoxy-[1,2,4] triazolo[1,5-c]pyrimidine-2-yl) pyridine sulfamide. The triazolopyrimidine sulfonamide compound is used as a herbicide in a rice field.
Owner:HEILONGJIANG UNIV

4'-pyridylpyrimidine compound and synthetic method and application thereof

The invention discloses a 4'-pyridylpyrimidine compound and a synthetic method and application thereof. By using a derivative iso-longitolanone of natural renewable resource turpentine as a raw material, a novel 4'-pyridylpyrimidine compound is prepared. Iso-longitolanone and 4-pyridylaldehyde are subjected to condensation to generate 7-(pyridine-4'-yl-methylene)iso-longitolanone; 7-(pyridine-4'-yl-methylene)iso-longitolanone and guanidine hydrochloride are subjected to condensation and cyclization to obtain a 4'-pyridylpyrimidine compound 6,6,10,10-tetramethyl-4-(pyridine-4'-yl)-5,7,8,9,10,10a-hexahydro-6H-6a,9-methanobenzo-2-quinazolinamine. The compound can specifically recognize copper ion, can be specifically complexed with Cu<2+> ion and generates quenching of blue fluorescence. Thus, the compound can be used as a fluorescence probe for detection of copper ion and has good practicality.
Owner:NANJING FORESTRY UNIV

Use of Quaternary Pyridinium Compounds for Vasoprotection and/or Hepatoprotection

The invention relates to a method for the treatment or prevention of diseases or conditions associated with vascular endothelium dysfunction or liver injury comprising the administration to a patient in a need of such treatment or prevention of a therapeutically or prophylactically effective amount of a compound selected from the group consisting of:wherein R represents hydrogen atom, CH3, OH, pyridyl (C5H4N), 1-methylpyridyl (C5H4N—CH3) or pyridyl substituted with hydroxy group ((OH)C5H3N), and X represents a physiologically acceptable counterion.
Owner:HEPENDO

Method of rapidly and quantitatively analyzing 48 amino acids

The invention discloses a method of rapidly and quantitatively analyzing 48 amino acids. A derivatization reagent combination for quantitatively analyzing and detecting an amino acid content by a derivatization HPLC-MS / MS method is provided, and comprises a derivatization reagent A and a derivatization reagent B; the derivatization reagent A is a mixed solution of n-propanol and 3-methylpyridine;and the derivatization reagent B is a mixed solution of dichloromethane, chloroformyl propyl ester and isooctane. Furthermore, a stable isotope internal standard solution combination, a sample pretreatment method and a liquid chromatography-tandem mass spectrometry method based on the derivatization method are established. The derivatization reagent proposed by the invention has high derivatization efficiency and low toxicity; the method requires fewer samples, the processing is simple and quick, the repeatability is good, and the detection cost is low; absolute quantitative analysis on 48 amino acids is realized by only 22 minutes, the analysis time is greatly shortened, and the detection throughput is improved; and great promotion and application value are achieved.
Owner:GUANGZHOU WOMEN AND CHILDRENS MEDICAL CENTER

Synthetic method of 2-chloro-5-chloromethyl pyridine

The invention discloses a synthetic method of 2-chloro-5-chloromethyl pyridine. The synthetic method comprising the following steps: adding an organic solvent, an acid buffering agent solution and an initiator into 3-methylpyridine; adjusting the pH value of the solution in a range of 4-5; letting nitrogen in; elevating temperature to 80-100 DEG C while stirring; stopping letting nitrogen in, letting chlorine in and continuing elevating temperature for a reaction; stopping heating, shutting a chlorine injection vavle off, letting nitrogen in and bubbling to drive the chlorine off; desolventizing a reaction solution through underpressure distillation to obtain brown-red oily liquid; and purifying the brown-red oily liquid to obtain a finished product. According to the invention, a liquid phase chlorination method is adopted; raw materials are subjected to a reaction in liquid; meanwhile an acid buffering agent solution is added to adjust a pH value in a range of 4-5; and by-products are decreased, so that the yield of a target product can reach to about 90%.
Owner:JIANGSU KESHENG CROP TECH

Alkylammonium salts of omepazole and esomeprazole

The present invention relates to new salts of omeprazole and esomeprazole respectively, i.e. salts of 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-benzimidazole and the (S)-enantiomer thereof. More specifically, the present invention relates to alkylammonium salt of the compounds, formed by a reaction of omeprazole and esomeprazole respectively and an alkylamine with formula NR?1#191R?2#191R?3#191 wherein R?1#191 is a linear, branched or cyclic C?1#191-C?12#191-alkyl group, R?2#191 and R?3#191 are hydrogen. The present invention also relates to a process for preparing crystalline salts, a pharmaceutical preparation and a method for treatment of gastric related disorders by administering the compound of the invention.
Owner:ASTRAZENECA AB

Fluorescent probe for detecting viscosity and hydrogen peroxide and synthesis method and application of probe

The invention discloses a fluorescent probe for detecting viscosity and hydrogen peroxide and a synthesis method and application of the probe, and belongs to the technical field of chemical analysis detection. The probe is obtained through a coupling reaction between aldehydic benzothiazole and a 4-methylpyridinium salt substituted by methylene phenylboronic acid. According to the structure of theprobe, due to the quenching effect of twisted intramolecular charge transfer (TICT), a probe molecule has almost no fluorescence emission characteristics. However, with the increase of the viscosityof an environmental system, the TICT effect is inhibited, and the probe molecule achieves strong fluorescence emission with the emission peak of 680 nm. In addition, the probe can also generate sensitive fluorescence response to H2O2, and the emission peak is 590 nm after the reaction. The concentration detection range of hydrogen peroxide is 0-25 Mumol L(-1), and the detection limit is 0.34 MumolL(-1). The probe can be used for detecting H2O2 in water and cells.
Owner:SHANGQIU NORMAL UNIVERSITY

Novel chiral sulfoxide compound and method for preparing esomeprazole by using novel chiral sulfoxide compound

The invention discloses a (S)-(((4-methoxy-3,5-dimethyl pyridine-2-yl)methyl)sulfinyl) ethyl thioformate compound, a preparation method of the compound and a process for preparing esomeprazole by using the compound. The compound and the preparation method have the remarkable advantages that: raw materials for synthesis are cheap and can be easily obtained; the reaction conditions are moderate; the yield of the prepared esomeprazole is high; the optical purity is high; the operation is safe; the environment is slightly polluted; and the compound is more suitable for industrial large-scale production.
Owner:CHENGDU EASTON BIOPHARMACEUTICALS CO LTD
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