334 results about "Methylpyridinium" patented technology

The invention discloses a quinazolinone compound containing 1, 2, 4-triazole thioether and synthesizing method and application of quinazolinone compound. The quinazolinone compound for preventing and curing plant pathogens is indicated by the general formula (I). Methyl anthranilate, formamide, ethyl bromoacetate, hydrazine hydrate, phenyl isothiocyanate, substitution benzyl halide or 2-chlorine-5 chloromethyl pyridine is used as raw material and subjected to six-step reaction to synthesize the target compound. The quinazolinone compounds A7, A8 and A19 are good in inhibitory activity on rice bacterial leaf blight germs. The quinazolinone compound A19 is good in inhibitory activity on citrus canker germs. The inhibitory activity on wheat scab germs of the quinazolinone compounds A14 and A18 and the inhibitory activity on apple rotting germs of the quinazolinone compound A8 are equal to that of control chemical hymexazol.

The invention relates to a MFI structure molecular sieve containing phosphorus and transition metal as well as its preparation method. The anhydrous chemical expression of the molecular sieve is (0-0.3) Na2O.(0.5-6) Al2O3.(1.3-10) P2O5.(0.7-15) MxOy.(70-97) SiO2, wherein M is selected from one or more of Fe, Co, Ni, Cu, Mn, Zn, Sn and Bi, x is expressed as atomicity of M, y is expressed as a number which satisfies the requirement of an oxidation state of M; No characteristic absorption peak is existed at 1633cm<-1> on infrared spectrum by molecular sieve trimethylpyridine adsorption. The preparation method comprises that phosphor and transition metal are introduced in molecular sieve with the MFI structure during ammonium exchanging, wherein the phosphor introduction is divided into two parts, a part of phosphor is introduced before introducing the transition metal or at the same time with transition metal introduction, the other part of the phosphor is introduced after the transitionmetal introduction. The provided molecular sieve is used for conversing hydrocarbon oil, the yield of dry gas and coke is low, and the yield of propylene and isobutene is high.

The invention discloses a method for synthesizing esomeprazole sodium. The method comprises the steps as follows: preparing 5-methoxy-2-(4-methoxy-3,5-dimethyl-2-pyridyl) methylthio-1H-benzimidazole, namely prochirality thioether; preparing crude esomeprazole sodium; refining the crude esomeprazole sodium; adding the prepared prochirality thioether and dried methylbenzene into D-(-) diethyl tartrate and water by stirring, adding titanium isopropylate, and stirring; and adding diisopropylamine at constant temperature, stirring, dropwise adding cumyl hydroperoxide with the mass concentration of 80%, ending the reaction, extracting, salifying, concentrating, washing and carrying out vacuum drying to obtain a crude product, and refining the crude product to obtain the esomeprazole sodium. The method is low in cost, toxicity and pollution, easy to operate, short in reaction time, high in product purity and easy for industrial production.

The invention relates to preparation and application of a pyrazole oxime ether compound (I) containing trifluoro methyl pyridine. The pyrazole oxime ether compound is prepared by carrying out condensation on pyrazole-containing hydroxamic acid (II) and 2-(4-chloromethyl phenoxyl)-5-trifluoro methyl pyridine (III). The pyrazole oxime ether compound (I) containing trifluoro methyl pyridine has an effective controlling effect on harmful insects and can be used for preparing insecticides for the fields of agriculture, horticulture and the like. A general formula of the pyrazole oxime ether compound (I) is shown in the specification.

The present invention relates to pharmaceutical compositions containing axitinib, which is known as N-methyl-2-[3-((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-ylsulfanyl]-benzamide or 6-[2-(methylcarbamoyl)phenylsulfanyl]-3-E-[2-(pyridin-2-yl)ethenyl]indazole, or crystalline forms thereof, that protect axitinib from degradation, including photodegradation, as well as the therapeutic use of such compositions. The present invention also relates to novel photodegradants of axitinib.

The invention relates to isoalantolactone derivatives and salts thereof and provides an isoalantolactone derivative as shown in a formula (I). Salification acids are selected from inorganic acids or organic acids; the inorganic acids are selected from hydrofluoric acid, hydrochloric acid, hydrobromic acid, hydroiodic acid, sulfuric acid, nitric acid, phosphoric acid, carbonic acid, boric acid, seleninic acid, phosphomolybdic acid, phosphorous acid and sulphurous acid; the organic acids are selected from citric acid, maleic acid, D-malic acid, L-malic acid, DL-malic acid, L-lactic acid, D-lactic acid, DL-acid, oxalic acid, methylsulfonic acid, pentanoic acid, oleic acid, lauric acid, p-toluene sulfonic acid, 1-naphthalenesulfonic acid, 2-naphthalenesulfonic acid, phthalic acid, tartaric acid, malonic acid, succinic acid, fumaric acid, glycolic acid, mercaptan acid, glycine, sarcosine, sulfonic acid, nicotinic acid, methylpyridine acid, isonicotinic acid, benzoic acid or substituted benzoic acid.

The invention relates to a mesoporous TiO2 supported V2O5 catalyst with high specific surface area and a preparation method and application thereof. Aiming at the disadvantages that the prior V2O5Tio2 has low catalytic activity, high reaction temperature, and poor selectivity and catalyst stability when 3-methylpyridine is ammoxidized to produce 3-cyanopyridine, the invention provides a mesoporous TiO2 supported V2O5 catalyst which has low reaction temperature, high transformation rate and good selectivity, is used for producing the 3-cyanopyridine by ammoxidizing the 3-methylpyridine and has high specific surface area, and a preparation method and application thereof. The catalyst comprises a carrier and an active constituent, the carrier adopts TiO2, and the active constituent adopts V2O5. The method for preparing the catalyst comprises the following steps: a template agent adopts organic amine, a titanium source adopts tetraisopropoxy titanium, a vanadium source adopts triisopropoxyvanadium oxide, and the TiO2 supported V2O5 catalyst is directly synthesized in a polytetrafluorine kettle under hydrothermal conditions. The catalyst is used for producing the 3-cyanopyridine by ammoxidizing the 3-methylpyridine in a gas phase.

The invention discloses a preparation method for high-purity milrinone (shown as a formula (I), 1,6-dihydro-2-methyl-6-oxo-3,4-bipyridine-5-carbonitrile), and belongs to the field of chemical medicines. The method comprises: employing 4-methylpyridine as a raw material and acetylating with acetyl chloride, and hydrolyzing after the reaction is finished, so as to obtain a compound of a formula (III); mixing the compound of the formula (III) with glacial acetic acid, acetic anhydride and triethyl orthoformate, and reacting at 35 DEG C-45 DEG C, so as to obtain a compound of a formula (IV); performing cyclization on the compound of the formula (IV) and alpha-cyanoacetamide, so as to obtain a crude product of a compound of the formula (I); and refining the crude product of the formula (I) compound through an ethanol-water system, so as to obtain a high-purity refined product with the maximum interplanar spacing d of 8.39 +/- 0.02 Angstrom. The technology is relatively mild in reaction conditions and relatively simple in operation, and is capable of preparing the milrinone product with high purity and a single crystal form. The obtained milrinone crystal form is relatively excellent in solubility in normal saline or glucose, and is beneficial for improvement of the preparation quality.

The invention discloses a carbon-carbon double bond bridged covalent organic framework material and a preparation method thereof, and relates to the field of covalent organic framework materials. According to the invention, N-alkyl-2, 4, 6-trimethylpyridine quaternary ammonium salt used as a core monomer and 2, 4, 6-tris(4-aldehyde phenyl)-1, 3, 5-triazine are used to synthesize the carbon-carbon double bond bridging covalent organic framework material through a heating reaction. The obtained covalent organic framework material has the advantages of high crystallinity, high specific surface area, regular open pore channel structure, rich photoelectric activity, good thermal stability and two-dimensional layered morphology.

The invention discloses an oxosynthesis method of methylpyridine-1-oxide, comprising two steps of preparation of a catalyst and oxidation reaction, wherein the preparation of the catalyst comprises the steps of after cleaning, high temperature boiling, drying and cooling pretreatment of activated carbon, adding into a phosphotungstic acid solution, stirring till complete soaking, and after ultrasonic treatment, evaporating to remove a solvent to obtain a phosphotungstic acid supported on active carbon catalyst; the oxidation reaction comprises the steps of mixing methylpyridine with the phosphotungstic acid supported on active carbon catalyst, stirring, adding hydrogen peroxide for reaction, and separating the phosphotungstic acid supported on active carbon catalyst to obtain methylpyridine-1-oxide filtrate being a methylpyridine-1-oxide crude product, and distilling under reduced pressure to obtain the product. When the method is used for preparing the catalyst, a carrier is cheap and convenient, a preparation process is simple, the catalyst in the oxidation reaction is less in use level, convenient to recycle, resuable and low in cost, product yield is up to 97%, product purity is up to 98% and productivity is more than 98%.

The invention discloses a method for preparing intermediate 5-bromo-2-methylpyridine. In the prior art, the dosage of aluminium trichloride is large; the catalytic effect is poor; the by-products are more; the yield of products is low; and the obtained products are difficult to separate. The method comprises the following steps: reacting diethyl malonate with alkali metal to generate salts, dripping 5-nitryl-2-chloropyridine into the salts for condensation reaction, and subsequently performing decarboxylation on the obtained product under acidic condition to obtain 5-nitryl-2-methylpyridine; performing hydrogenation reduction on the 5-nitryl-2-methylpyridine under the catalysis of Pd/C catalyst to obtain 5-amido-2-methylpyridine; and reacting the 5-amido-2-methylpyridine with acid to generate salts, dripping bromine, dripping a sodium nitrite water solution, and obtaining the 5-bromo-2-methylpyridine. The method has mild reaction conditions, easy operation, simple post-treatment, good catalytic effect, high yield of each step and high yield of final products, and is particularly suitable for industrialized production.

The invention provides a triazolopyrimidine sulfonamide compound and synthetic methods and application thereof, relating to a penoxsulam analog and a synthetic method and application thereof. The objective of the invention is to overcome the problems of great synthesis difficulty and high cost of conventional penoxsulam. The triazolopyrimidine sulfonamide compound has a structural formula described in the specification. The method 1 comprises the following steps: 1, preparing 2-methyl-3-chlorobenzenesulfonyl chloride; and 2 preparing a finished product so as to obtain 3-chloro-2-methyl-N-(5,8-dimethoxy-[1,2,4] triazolo[1,5-c]pyrimidine-2-yl) benzsulfamide. The method 2 comprises the following steps: 1, preparing 2-mercapto-3-trifluoromethylpyridine; and 2, preparing 3-trifluoromethylpyridine-2-sulfonyl chloride; and 3, preparing a finished product so as to obtain 3-trifluoro-methyl-N-(5,8-dimethoxy-[1,2,4] triazolo[1,5-c]pyrimidine-2-yl) pyridine sulfamide. The triazolopyrimidine sulfonamide compound is used as a herbicide in a rice field.

The invention discloses a 4'-pyridylpyrimidine compound and a synthetic method and application thereof. By using a derivative iso-longitolanone of natural renewable resource turpentine as a raw material, a novel 4'-pyridylpyrimidine compound is prepared. Iso-longitolanone and 4-pyridylaldehyde are subjected to condensation to generate 7-(pyridine-4'-yl-methylene)iso-longitolanone; 7-(pyridine-4'-yl-methylene)iso-longitolanone and guanidine hydrochloride are subjected to condensation and cyclization to obtain a 4'-pyridylpyrimidine compound 6,6,10,10-tetramethyl-4-(pyridine-4'-yl)-5,7,8,9,10,10a-hexahydro-6H-6a,9-methanobenzo-2-quinazolinamine. The compound can specifically recognize copper ion, can be specifically complexed with Cu<2+> ion and generates quenching of blue fluorescence. Thus, the compound can be used as a fluorescence probe for detection of copper ion and has good practicality.

The invention relates to a method for the treatment or prevention of diseases or conditions associated with vascular endothelium dysfunction or liver injury comprising the administration to a patient in a need of such treatment or prevention of a therapeutically or prophylactically effective amount of a compound selected from the group consisting of:

wherein R represents hydrogen atom, CH₃, OH, pyridyl (C₅H₄N), 1-methylpyridyl (C₅H₄N—CH₃) or pyridyl substituted with hydroxy group ((OH)C₅H₃N), and X represents a physiologically acceptable counterion.

The invention relates to an application of an isoalantolactone derivative and a salt thereof in the preparation of medicines for treating lung fibration, and provides an isoalantolactone derivative represented by formula (I). An acid for forming the salt is an inorganic acid or an organic acid, the inorganic acid is selected from hydrofluoric acid, hydrochloric acid, hydrobromic acid, hydroiodic acid, sulfuric acid, nitric acid, phosphoric acid, carbonic acid, boric acid, seleninic acid, phosphomolybdic acid, phosphorous acid and sulfurous acid, and the organic acid is selected from citric acid, maleic acid, D-malic acid, L-malic acid, DL-malic acid, L-lactic acid, D-lactic acid, DL-lactic acid, oxalic acid, methanesulfonic acid, pentanoic acid, oleic acid, lauric acid, p-methyl benzenesulfonic acid, 1-naphthalenesulfonic acid, 2-naphthalenesulfonic acid, phthalic acid, tartaric acid, propane diacid, succinic acid, fumaric acid, glycollic acid, thioglycollic acid, glycine, sarcosine, sulfonic acid, nicotinic acid, methylpyridine acid, isonicotinic acid, benzoic acid and substituted benzoic acid.

The invention discloses a method of rapidly and quantitatively analyzing 48 amino acids. A derivatization reagent combination for quantitatively analyzing and detecting an amino acid content by a derivatization HPLC-MS/MS method is provided, and comprises a derivatization reagent A and a derivatization reagent B; the derivatization reagent A is a mixed solution of n-propanol and 3-methylpyridine;and the derivatization reagent B is a mixed solution of dichloromethane, chloroformyl propyl ester and isooctane. Furthermore, a stable isotope internal standard solution combination, a sample pretreatment method and a liquid chromatography-tandem mass spectrometry method based on the derivatization method are established. The derivatization reagent proposed by the invention has high derivatization efficiency and low toxicity; the method requires fewer samples, the processing is simple and quick, the repeatability is good, and the detection cost is low; absolute quantitative analysis on 48 amino acids is realized by only 22 minutes, the analysis time is greatly shortened, and the detection throughput is improved; and great promotion and application value are achieved.

The present invention relates to new salts of omeprazole and esomeprazole respectively, i.e. salts of 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-benzimidazole and the (S)-enantiomer thereof. More specifically, the present invention relates to alkylammonium salt of the compounds, formed by a reaction of omeprazole and esomeprazole respectively and an alkylamine with formula NR?1#191R?2#191R?3#191 wherein R?1#191 is a linear, branched or cyclic C?1#191-C?12#191-alkyl group, R?2#191 and R?3#191 are hydrogen. The present invention also relates to a process for preparing crystalline salts, a pharmaceutical preparation and a method for treatment of gastric related disorders by administering the compound of the invention.

The invention discloses a (S)-(((4-methoxy-3,5-dimethyl pyridine-2-yl)methyl)sulfinyl) ethyl thioformate compound, a preparation method of the compound and a process for preparing esomeprazole by using the compound. The compound and the preparation method have the remarkable advantages that: raw materials for synthesis are cheap and can be easily obtained; the reaction conditions are moderate; the yield of the prepared esomeprazole is high; the optical purity is high; the operation is safe; the environment is slightly polluted; and the compound is more suitable for industrial large-scale production.