8 results about "Hemorrhagic strokes" patented technology

The present application relates to the technical field of medical devices, in particular to an automatic infusion control method and system based on brain blood flow monitoring, the automatic infusion control method comprising the following steps: step one, monitoring blood flow velocity and pulsatility index of large vessels; step two, comparing real-time blood flow velocity with initial blood flow velocity and real-time pulsatility index with initial pulsatility index respectively; step three, determining based on the comparison results, including: if the real-time blood flow velocity is less than the initial blood flow velocity and the difference between the two is greater than a first threshold, then determining that it is ischemic stroke; if the real-time pulsatility index is greater than the initial pulsatility index and the difference between the two is greater than a second threshold, then determining that it is hemorrhagic stroke; step four, based on the determination results of ischemic stroke or hemorrhagic stroke, using a predetermined infusion mechanism to control infusion. The automatic infusion control method in the present application can improve the infusion timeliness of the existing automatic infusion control system and realize the infusion automation thereof.

The invention relates to 4 serum peptide patterns for diagnostics of intracranial hemorrhagic stroke (ICH) in humans and differential diagnosis from acute ischemic stroke that are defined using a list of the 34 quantitative peptides that in sera of patients with ICH are increased 2 folds or more as compared with individuals without stroke and patients with acute ischemic stroke and a list of 16 qualitative peptides detectable in sera of the patients with ICH but not detectable in the sera of individuals without stroke and in sera of patients with acute ischemic stroke.

The present invention relates to a pharmaceutical use, of a compound of formula I or a salt thereof, for improving mortality, neurological impairment, and / or daily activity in patients with resuscitated cardiac arrest receiving target temperature management (TTM) for maintaining a temperature between about 32°C and about 36°C, patients with ischemic or hemorrhagic stroke receiving TTM, patients with traumatic brain or spinal cord injury receiving TTM, or patients with hypoxic-ischemic encephalopathy receiving TTM.

The invention relates to a method for selecting a patient suffering stroke for a reperfusion therapy based on determining the level of retinol binding protein-4 (RBP4) and N-terminal fragment of B-type natriuretic peptide (NT-proBNP) in an isolated sample of said patient. The invention also relates to a method of differentiating ischemic stroke from haemorrhagic stroke and to kits comprising reagents to carry out the methods.

The application claims a kind of based on magnetic nano particle enhanced magnetic induction hemorrhagic cerebral apoplexy detection system, belong to biomedical engineering field cerebral disease detection and monitoring and physiological signal detection field, it includes: signal source, power amplifier, series resonance circuit, receiving coil, excitation coil, acquisition card and computer, wherein, the signal source is connected with power amplifier, the power amplifier is connected with series resonance circuit, the series resonance circuit is connected with receiving coil and excitation coil respectively, the receiving coil is connected with acquisition card, and the acquisition card is connected with computer;The application includes hardware series resonance circuit design, MAXWELL simulation coil design and helmholtz coil production, hardware system building and experimental test.The application proposes a kind of with high sensitivity can bed-side monitoring system, timely detection cerebral hemorrhage, and it has important significance for the discrimination of cerebral apoplexy type and related cerebral disease monitoring.

The present invention provides an application of α-asarone in the preparation of a medicine for preventing or treating hemorrhagic strokes. α-asarone has the structure shown in formula I, and may significantly improve short-term neurological deficits and long-term learning and memory functions of model rats, reduce cerebral edema, improve the permeability of the blood-brain barrier, and prevent or mitigate the atrophy of brain tissue during a recovery period. α-asarone has a precise therapeutic effect on animal models of hemorrhagic stroke without obvious toxic side effects, and is expected to have great application prospects as a medicine for preventing / treating hemorrhagic strokes.

This invention discloses a class of 3-substituted phthalide compounds (I) and their pharmaceutically acceptable salts, their preparation methods, pharmaceutical compositions, and their use in the preparation of drugs for the treatment and / or prevention of neurological diseases, including but not limited to vascular dementia, Alzheimer's disease, frontotemporal dementia, Prion's disease, Lewy body dementia, Parkinson's disease, Huntington's disease, HIV-related dementia, multiple sclerosis, amyotrophic lateral sclerosis, neuropathic pain, ischemic stroke, hemorrhagic stroke, and neurological damage caused by traumatic brain injury;

This invention discloses a class of piperidine alkyl dihydroxyphthalide compounds (I) and their pharmaceutically acceptable salts, their preparation methods, pharmaceutical compositions, and their use in the preparation of medicaments for treating and / or preventing diseases by means of anti-oxidative stress, inhibition of amyloid aggregation, metal ion complexation, or anti-neuroinflammatory effects, including but not limited to vascular dementia, Alzheimer's disease, frontotemporal dementia, Prion's disease, Lewy body dementia, Parkinson's disease, Huntington's disease, HIV-related dementia, multiple sclerosis, amyotrophic lateral sclerosis, neuropathic pain, ischemic stroke, hemorrhagic stroke, and neurological damage caused by traumatic brain injury;