13results about How to "Reduce inflammatory damage" patented technology

The invention discloses a neuraminidase-targeted drug-loaded nanoparticle as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations. Polysialic acid and poly (lactic-co-glycolic acid) are connected through ester bond connection to obtain the drug-loaded nanoparticles with stable structure and performance, and the drug-loaded nanoparticles have the effect of targeting neuraminidase and also have high efficiency of entering cells; the antibiotic drug is further dispersed in the drug-loaded nanoparticles, the inflammation regulating agent is adsorbed on the surface of the drug-loaded nanoparticles, and the drug-loaded nanoparticles can deliver the antibiotic drug and the inflammation regulating agent to the pig Gleisseria in the pig body. According to the present invention, the antibiotic drug and the inflammation regulating agent are released under the acidic environment at the infection site in the pig body, such that the pig Gleisseria is efficiently killed, the inflammation damage caused by bacterial infection and the toxic damage of the antibiotic drug are reduced, and the good application prospect is provided in the preparation of the drug for preventing and / or treating the pig Gleisseria infection.

The invention relates to the technical field of biological medicine, in particular to radix puerariae and sesame coffee for improving non-alcoholic fatty liver and application of the radix puerariae and sesame coffee. The radix puerariae and sesame coffee comprises the following components in parts by weight: 0.5 part of a fructus cannabis polypeptide solution, 0.5 part of radix puerariae polypeptide solution and 9 parts of coffee. After continuous treatment for 7 weeks, according to liver appearance and liver histopathology observation, it is found that the radix puerariae and sesame coffee mixed liquid effectively reduces lipid deposition and liver fat, and the liver fat lesion is improved. Experimental results show that the radix puerariae and hemp coffee has a remarkable lipid-lowering effect, and can effectively reduce liver fat particles, reduce inflammatory injury, improve liver tissue pathological changes and relieve NAFLD mouse liver tissue injury.

The invention particularly relates to a glycosylated dendrimer for co-delivery of small interfering RNA (Ribonucleic Acid) and small molecular drugs as well as a preparation method and application of the glycosylated dendrimer. The nano platform provided by the invention is characterized in that an anti-inflammatory drug resveratrol (Res) and electrostatic adsorption small interfering RNA (si-Cp2e1) are loaded in a glycosylated dendrimer G5-Gal. The preparation method and the application comprise the following steps: preparation of G5-Gal, preparation of Res (at) G5-Gal, and preparation of Res (at) G5-Gal / si-Cp2e1. The preparation method is simple, the required raw materials are easy to obtain, the synthesis process is simple and convenient, separation and purification are easy, and the synthesized nano-drug has a liver targeting capability, can realize dual treatment of small molecule drug-small interfering RNA, and has a potential application prospect in the aspect of treatment of alcohol-related liver diseases.

The present invention discloses an application of an immunomodulatory peptide in the preparation of a drug for preventing and treating bacterial infection, and belongs to the field of biomedical technology; the rice-derived immunomodulatory peptide RDP3 can inhibit bacterial infection in mice, and can alleviate the inflammatory damage of the lung tissue of infected mice and reduce the level of inflammatory factor protein in the serum of infected mice to a certain extent, and can also improve the survival rate of sepsis model mice. RDP3 exerts an antibacterial effect by recruiting phagocytes to the infected site. In view of the unique antibacterial mechanism of RDP3, it can provide a basis for the research and development of RDP3 as a polypeptide anti-infective drug, and provide candidate molecules for the research and development of peptide antibiotics.

The application provides a mucosal lactobacillus with anti-feline pestivirus pathogenic effect and application thereof, and relates to the technical field of probiotics, veterinary medicine and pet health care. The mucosal lactobacillus with anti-feline pestivirus pathogenic effect is named mucosal lactobacillus WH-3221, and is preserved in the China Center for Type Culture Collection with a preservation number of CCTCC NO: M 2026683. The mucosal lactobacillus WH-3221 can realize protection of intestinal barrier by regulating intestinal metabolic product spectrum, and has an anti-feline pestivirus effect, thereby significantly reducing the mortality of cats infected with feline pestivirus and relieving clinical symptoms. The mucosal lactobacillus WH-3221 or a probiotic preparation containing the mucosal lactobacillus WH-3221 can be used for preparing products for preventing and / or treating diseases or symptoms caused by feline pestivirus infection, and for preparing products for regulating the intestinal metabolic product spectrum of cats, and has a wide application prospect.

The application discloses a kind of nanocomposite hydrogel for treating osteoarthritis and its preparation method and application, the nanocomposite hydrogel includes cerium dioxide nanoparticles, the cerium dioxide nanoparticles are modified with hyaluronic acid;Ergothioneine is loaded on hyaluronic acid modified cerium dioxide nanoparticles to form nanocomposite EGT-CeO2@HA;And temperature-sensitive hydrogel carrier, the nanocomposite EGT-CeO2@HA is uniformly dispersed in the temperature-sensitive hydrogel carrier.This composite hydrogel can activate ATF4-dependent pro-survival autophagy pathway, reduce cartilage cell inflammatory damage, and improve cartilage degeneration.

The invention discloses a traditional Chinese medicine compound composition for preventing and treating liver injury as well as a preparation method and application thereof. The compound composition comprises verbena, alfalfa, Chinese ladiestresses root, hairyvein agrimony, fingered citron, malt and hyperforin perforatum. The traditional Chinese medicine composition is simple in composition and reasonable in proportion, and animal experiments prove that the traditional Chinese medicine composition can improve the liver function, relieve liver inflammation injury, inhibit liver cell necrosis and fatty degeneration, inhibit oxidative stress and resist lipid peroxidation injury and has good prevention and treatment effects on liver injury, cholestatic liver diseases and the like caused by drugs. And the traditional Chinese medicine composition can obviously improve the symptoms such as weakness, nausea, skin and sclera yellow staining, yellow urine, itching, stomachache, hypochondrium lumps, body emaciation and the like in the liver injury period. The medicine is simple in preparation method, convenient to take, low in price, small in side effect and good in curative effect, and provides a good choice for vast patients with hepatopathy.

The application of ursolic acid in the preparation of drugs for treating liver fibrosis can effectively solve the problem of medication for treating liver fibrosis. By regulating the differentiation of immune cells (Th17 cells) and reducing inflammatory damage, ursolic acid intervenes in the liver's immune microenvironment, effectively reversing liver fibrosis, and thus enabling its application in the preparation of drugs for treating liver fibrosis. This invention develops a new drug for treating liver fibrosis, opening up a new avenue for medication in the treatment of liver fibrosis. It represents a major innovation in the treatment of liver fibrosis, demonstrating good efficacy, safety, and practical application value.

The application discloses application of a pilose antler polysaccharide in preparation of a radioactive liver injury protection product and belongs to the technical field of biological pharmacy. The application of the pilose antler polysaccharide in preparation of the radioactive liver injury protection product shows that the polysaccharide can not only effectively reduce oxidative stress and inflammatory injury, but also specifically intervene in the core pathological mechanism of the radioactive liver injury, that is, the pilose antler polysaccharide can inhibit progressive liver fibrosis by down-regulating the expression of a TGF-beta signal path and regulate the expression balance of BAX / Bcl-2 genes to block liver cell apoptosis mediated by a mitochondrion path, thereby effectively relieving liver injury caused by ionizing radiation, and the pilose antler polysaccharide has no toxic side effects and has a wide application prospect.

This invention provides a 20(S)-ginsenoside Rg2 amino acid ester derivative, its preparation method, and its uses, belonging to the pharmaceutical field. This invention relates to its application in drugs for treating shock diseases. In vitro cell experiments show that the compound of this invention can not only improve the survival rate of hypoxic-damaged cardiomyocytes, inhibit the increase of LDH, MDA, TNF-α, and IL-6 levels in hypoxic-damaged cells, and increase SOD activity, but also promote the expression of p-PI3K and p-Akt in hypoxic-damaged cells, exhibiting a strong protective effect against hypoxic cardiomyocytes. This invention can also increase blood pressure in shock model rats, inhibit the increase of heart rate, reduce lactate content to improve tissue perfusion, and reduce PCO2 content while increasing HCO3 content. ‑ It reduced the levels of TCO2 and BE, corrected the acid-base balance in the body, significantly reduced the content of MDA, LDH, TNF-α and IL-6, increased the activity of SOD, inhibited oxidative stress and inflammatory response, and showed good anti-shock biological activity.

The invention belongs to the technical field of biological medicine, and particularly relates to application of mesenchymal stem cells acting on immune barrier reconstruction of an inflammation part. The specific mechanism is that the mesenchymal stem cells inhibit proliferation of lymphocytes, Th1 cells and Th17 cells, inhibit activated immune cells from secreting inflammatory factors TNF-alpha and promote proliferation of Treg lymphocytes and expression of IDO, and inflammatory response is reduced through immunoregulation, so that wounds are healed.

The invention belongs to the technical field of biology and medicine, and discloses an ACLY-targeted PROTAC chimera which takes a glycol chain as a connecting chain and has anti-MASH activity, the structural general formula of the ACLY-targeted PROTAC chimera is as shown in formula 1: # imgabs0 #, R is-(CH2-O-CH2) n-, and n is 2-6. The synthesized PROTAC compound is a new compound, in a high-fat model established by L02 and HepG2, the synthesized PROTAC compound has the activity of reducing the TG content, and compared with a bullet, the synthesized PROTAC compound has low-toxicity activity in human hepatoma carcinoma cells HepG2, human normal hepatoma cells L02 and human umbilical vein endothelial cells HUVEC, and can be used for preparing a medicine for treating liver cancer. The medicine is a novel medicine for resisting non-alcoholic steatohepatitis with low toxicity and high efficiency. The application field of the PROTAC technology is widened while efficient treatment of the non-alcoholic steatohepatitis is developed.

The invention discloses a moisturizing mask and a preparation method thereof, and relates to the technical field of masks, the mask comprises a mask matrix and essence; the essence is prepared from the following raw materials in parts by weight: 80-90 parts of water, 4-6 parts of butanediol, 1-3 parts of 1, 3-butanediol and 1-3 parts of 1, 3- The cosmetic is prepared from the following raw materials in parts by weight: 1 to 5 parts of 1, 3-propylene glycol, 1 to 2 parts of betaine, 0.5 to 1.5 parts of glycerol, 1 to 3 parts of glyceryl polyether-26, 0.1 to 1 part of p-hydroxyacetophenone, 0.1 to 0.5 part of saccharide isomeride, 0.1 to 0.5 part of carbomer sodium, 0.1 to 0.5 part of dendrobium huoshanense stem extract, 0.1 to 0.3 part of cottonrose hibiscus leaf extract, 0.1 to 0.3 part of tamarind seed fermentation extract, 0.01 to 0.05 part of sodium hyaluronate, 0.001 to 0.01 part of oligopeptide-1, 0.001 to 0.005 part of citric acid and 0.001 to 0.005 part of sodium citrate. And 0.0001 to 0.001 part of acetyl hexapeptide-8. The moisturizing performance of the mask is remarkably improved.