36 results about "Growth hormone secretion" patented technology

An agent for prevention or treatment of diseases involving degeneration or death of nerve cells, characterized by containing a growth hormone secretion promoting substance as an active ingredient, is provided.

A method and pharmaceutical composition for inhibiting the effect of glucocorticoids, particularly dexamethasone, which suppress growth hormone secretion, by administering ghrelin or a ghrelin analogue, for example, [Aib2, Glu3(NH-hexyl)]hGhrelin(1-28)-NH2 (SEQ ID NO:2) or other suitable ghrelin agonist, to counteract the catabolic effects of said dexamethasone and other natured glucocorticoids.

Leptin resistance ameliorating agents comprising as the active ingredient a neurotrophic factor such as BDNF or a trk receptor ligand, namely, agents for ameliorating, treating or preventing hypertension, sterility, obesity, glucose metabolic disorders, ischemic diseases, growth hormone secretion insufficiency, growth hormone hyposecretion, immune function disorder, etc. caused by leptin resistance.

The invention discloses a compound feed additive capable of replacing antibiotics and used for promoting growth of weaned piglets as well as a preparation method and application of the compound feed additive, the additive comprises organic acid, enteric plant essential oil coated particles and a carrier, and the mass ratio of the organic acid to the enteric plant essential oil coated particles tothe carrier is (65-78): (1-4): (20-35); wherein the organic acid comprises benzoic acid, fumaric acid, citric acid, lactic acid and fumaric acid, essential oil in the enteric plant essential oil coated particles comprises one or more of cinnamon oil, thymol, carvacrol and origanum oil, and the carrier is white carbon black. The additive replaces antibiotics to relieve stress of weaned piglets, promote growth hormone secretion, diminish inflammation and promote daily gain of the piglets, and can increase digestive enzyme activity of intestinal tracts of the piglets, increase the number of bifidobacteria of the intestinal tracts, maintain intestinal health of the intestinal tracts and improve immunity of the piglets.

The invention provides an application of Lactobacillus plantarum SG5 in gamma-aminobutyric acid. The Lactobacillus plantarum SG5 is preserved in Guangdong Microbial Culture Collection Center at Guangdong Institute Of Microbiology on March 16, 2016 with the preservation number of GDMCC No:60020. Fermentation using the Lactobacillus plantarum SG5 makes the GABA content reach 59 [mu]g / mL. The GABA has multiple beneficial health functions of lowering the blood pressure, promoting the growth hormone secretion and lowering cholesterols, bases are provided for the development of new healthcare products rich in the GABA, and the Lactobacillus plantarum SG5 has wide application prospect when applied to the development of foods and healthcare products rich in the GABA.

The invention discloses pseudomonas putida which is classified and named as pseudomonas putida, the strain number is LWPZF, the pseudomonas putida is preserved in China Center for Type Culture Collection, the preservation serial number is CCTCC NO: M 2016008, and the preservation data is Jan 5th, 2016. The invention further discloses application of the pseudomonas putida to promotion of growth of cercidiphyllum japonicum. The LWPZF strain has high inorganic phosphorus decomposition capacity and growth hormone secretion capacity; germination of cucumber seeds can be obviously promoted; the LWPZF fungicide is inoculated with cercidiphyllum japonicum seedlings; it is proved by results that the fungicide can obviously promote growth of cercidiphyllum japonicum seedlings; meanwhile, the culture has a certain antagonistic effect on fusarium oxysporum, rhizoctonia solani, rhizoctonia, rice blast pathogen and other phytopathogen; therefore an excellent strain resource is provided for development of a biofertilizer special for cercidiphyllum japonicum.

The invention provides a lactobacillus plantarum SG5 for producing gamma-aminobutyric acid (GABA). The lactobacillus plantarum SG5 is preserved in the Guangdong Microbiological Culture Collection Center; the collection address is the Guangdong Institute of Microbiology; the preservation date is March 16, 2016; the preservation number is GDMCC No: 60020. The lactobacillus plantarum SG5 is used for fermentation, so that the content of GABA can reach 59 [mu]g / mL; the GABA has a variety of beneficial healthcare functions of lowering blood pressure, promoting growth hormone secretion, lowering cholesterol and the like, so as to provide basis for the development of new GABA-rich health-care food; the lactobacillus plantarum SG5 is applied to the development of foods and health-care products, and has wide application prospects.

A method and pharmaceutical composition for inhibiting the effect of glucocorticoids, particularly dexamethasone, which suppress growth hormone secretion, by administering ghrelin or a ghrelin analogue, specifically [Aib2, Glu3(NH-hexyl)]hGhrelin(1-28)-NH2, to counteract the catabolic effects of said dexamethasone and other natural glucocorticoids.

The invention discloses a sleep aiding health product and a preparation method thereof. The sleep aiding health product is characterized by being prepared from the following ingredients in percentage by weight: 80% of gamma aminobutyric acid and 20% of spine date seed saponin. The preparation method comprises preparation steps as following: 1, preparation of the gamma aminobutyric acid; 2, preparation of the sleep aiding health product. The sleep aiding health product has the beneficial effects of calming nerves, resisting anxiety, reducing blood pressure and promoting growth hormone secretion of children, plays a nutritious role in a development process of the nervous system, has remarkable improvement effect on various symptoms such as Parkinson's disease, senile dementia, neurasthenia and the like, and can effectively reduce blood ammonia; the ingredient gamma aminobutyric acid contained in the sleep aiding health product further has functions of preventing skin aging, eliminating body odor, improving lipid metabolism, preventing arteriosclerosis, efficiently reducing weight and the like.

The invention relates to Chinese wolfberry vinegar rich in Monacolin K and gamma-aminobutyric acid and a preparation method thereof. The Chinese wolfberry vinegar is prepared by the following steps of: preparing germinated rice by using glutinous rice, boiling and gelatinizing the germinated rice, cooling the obtained paste, inoculating the cooled paste with lactic acid bacteria and monascus, performing acidifying, liquefying and saccharifying at the same time to obtain saccharified mash, adding water into Chinese wolfberry fruits, performing pulping, mixing Chinese wolfberry pulp with the saccharified mash, inoculating the obtained mixture with saccharomyces cerevisiae, carrying out alcoholic fermentation, inoculating the fermented material with acetic acid bacteria, and carrying out liquid deep ventilation fermentation. In the germination process of the glutinous rice, the content of gamma-aminobutyric acid is remarkably increased, and the aminobutyric acid has the activities of reducing blood pressure, calming the mind, improving kidney function and liver function, promoting long-term memory, promoting growth hormone secretion and the like. The germinated rice is fermented by the functional monascus, so that a large amount of lovastatin substances can be generated and have the functions of blocking cholesterol synthesis and regulating blood fat. In addition, the Chinese wolfberry fruits are rich in lycium barbarum polysaccharides, polyphenols and flavonoids, and have a good antioxidant effect. The Chinese wolfberry vinegar is red and bright in color, refreshing in taste,outstanding in ester fragrance and mellow in sour feeling.

The objectives are to find a substance or a composition capable of promoting the production of ghrelin with physiological activities such as growth hormone secretion effect, and to provide a pharmaceutical comprising it as the active ingredient. The pharmaceutical is a ghrelin production promoter comprising Rikkunshi-to as the active ingredient.

The invention provides application of lactobacillus pentosus SS6 to producing gamma-aminobutyric acid. The lactobacillus pentosus SS6 is preserved at the Microbiology Strain Preservation Center in Guangdong province on the preservation date of October 13th, 2016, the preservation address is the Institute of Microbiology in Guangdong province, and a preservation number of the lactobacillus pentosus SS6 is GDMCC No.60086. The application has the advantages that the content of the GABA (gamma-aminobutyric acid) fermented and produced by the aid of the lactobacillus pentosus can reach 3.09 mg / mL, the GABA has diversified beneficial healthcare functions of lowering blood pressures and cholesterol, promoting growth hormone secretion and the like, the basis can be provided for developing novel healthcare foods with abundant gamma-aminobutyric acid, and the lactobacillus pentosus SS6 has a broad application prospect when applied to developing the foods and healthcare products with the abundant GABA.

A regulator for regulating physiological functions, such as activity of increasing an intracellular calcium ion concentration, activity of promoting growth hormone secretion, activity of promoting eating, regulatory activity relating to fat accumulation, activity of ameliorating heart function and activity of stimulating gastric acid secretion, of ghrelin, which regulator comprises a fatty acid of carbon number 2-35 or its derivative, and use thereof.

Disclosed are: a growth hormone secretion stimulator which comprises a milk-derived basic protein fraction as an active ingredient and can stimulate the secretion of a growth hormone through the stimulation of the secretion of ghrelin that has an activity of stimulating the secretion of the growth hormone; and a method for stimulating the secretion of ghrelin by using a milk-derived basic proteinfraction. The growth hormone secretion stimulator can be ingested on a daily basis and is highly safe to be ingested for a long period.

The invention discloses a premix for body shape improvement and meat quality improvement of growing-finishing pigs, which is prepared from the following raw materials in percentage by mass: 8 to 12 percent of phytosterol, 15 to 25 percent of bioactive peptide, 40 to 60 percent of betaine, 8 to 12 percent of fructus perillae extract and 8 to 12 percent of compound amino acid. After the feed is used for a period of time, the body shape of growing-finishing pigs is obviously improved, the growth speed is obviously increased, and the meat quality is obviously improved after slaughtering. The components in the formula have a synergistic effect in the aspects of growth hormone secretion regulation and control, muscle growth mechanism regulation and control, fat metabolism redistribution, body antioxidation, muscle growth amino acid supply and the like, and the problems that the body shape of the growing-finishing pigs is not obviously improved and the meat quality is reduced are jointly solved.

The invention discloses pyrazolo [1,5-a]pyridine pharmaceutical molecules used for skin ulcer nursing and a preparation method and an application thereof, which belong to the technical field of medicine synthesis. The technical scheme has the main points that the pyrazolo [1,5-a]pyridine pharmaceutical molecules have a following molecular structure shown as the specification. The invention also discloses the preparation method of the pyrazolo [1,5-a]pyridine pharmaceutical molecules and the application of the pyrazolo [1,5-a]pyridine pharmaceutical molecules in preparation of a pharmaceuticalcomposition for skin ulcer nursing. The thiazepin compounds have the advantages of keeping calm, promoting growth hormone secretion, resisting ulcer, and sterilizing; the pyrazolo [1,5-a]pyridine pharmaceutical molecules can be synthesized and an antibacterial activity test is carried, the compound has good inhibition activity on bacillus anthracis and staphylococcus due to skin ulcer, a drug ointment is prepared, a clinical nursing experiment is carried out, and the nursing effect is obvious.

The invention discloses a pyridino-[1,5-a]pyridine drug and a preparation method and composition thereof and application of the pyridino-[1,5-a]pyridine drug in nursing of a skin ulcer patient, and belongs to the technical field of medicine synthesis. The technical scheme comprises the key points that the pyridino-[1,5-a]pyridine drug molecule has a following molecular structure. The invention also specifically discloses the preparation method of the pyridino-[1,5-a]pyridine drug for skin ulcer care and the application in preparation of the pharmaceutical composition for skin ulcer care. By combining a thiazepine compound which has the advantages of sedation, promotion of growth hormone secretion, anti-ulcer, sterilization and the like, the pyridino-[1,5-a]pyridine drug molecule for skin ulcer care is synthesized, antibacterial activity tests are carried out, and it is showed that the compound had good inhibitory activity against Staphylococcus epidermidis and Staphylococcus aureus which easily give rise to skin ulcer.

The present invention relates to a growth promotion effect of coumaric acid and, more specifically, to a pharmaceutical composition, a food composition, and an animal feed composition, which are for growth promotion and contain coumaric acid as an active ingredient. The composition containing coumaric acid as an active ingredient, of the present invention, promotes chondrocyte proliferation and growth hormone secretion, thereby finally having an effect of promoting growth, and thus the composition of the present invention is effective in not only growth and skeletal formation of growing children and adolescents, but also height growth therapy by being used alone or in combination with growth hormone therapy.

The invention relates to a biological food promoting the secretion of sex hormone in body, which pertains to the technical field of the production of biological health-care foods and external products. According to the principle of prevention and cure of traditional Chinese medical science, the biological food adopts various safe and nourishing biological raw materials comprising radix astragali,radix codonopsis pilosulae, sealwort, radices morindae, Eucommia ulmoides, fructus psoraleae, artemisia oil, wheat germ oil, soy isoflavones, EM Original Solution, L- arginine, etc. which can be taken orally and for external use and are produced into the biological food and an external product which can promote the secretion of sex hormone in body. The product is diversified in variety, exquisite, fashionable, convenient and suitable for people of various ages to use; if being taken insistently, the biological food can promote the long-term secretion of sex hormone in body, thereby achieving the purpose of preventing and curing diseases, improving and promoting the quality of sexual life, keeping blooming energy and physique, keeping youth, beauty and health and resisting senility radically.

The present invention provides a growth hormone secretion regulator or an anti-aging agent comprising aspartic acid and valine as active ingredients. The present invention also provides a pharmaceutical, food, nutritional supplement (supplement), or feeding stuff comprising the growth hormone secretion regulator or anti-aging agent.

The present invention relates to a method of administering to a mammal between from about 0.01 mg and about 4.9 mg of melatonin followed by physical exercise wherein said exercise occurs within 60 minutes following said administration of melatonin to increase serum growth hormone levels.

The objectives are to find a substance or a composition capable of promoting the production of ghrelin with physiological activities such as growth hormone secretion effect, and to provide a pharmaceutical comprising it as the active ingredient. The pharmaceutical is a ghrelin production promoter comprising Rikkunshi-to as the active ingredient.

A growth hormone secretion promoter mediated by a growth hormone-releasing hormone secretion-promoting action using a milk-derived basic protein fraction as an active ingredient, and a growth hormone-promoting agent using a milk-derived basic protein fraction Methods of releasing hormone secretion. This growth hormone secretion promoter can be ingested daily, and has high safety even after long-term ingestion.

A method which enables strengthening muscles in an extremely efficient manner is provided. This muscle training method involves winding a belt around at least one of the user's arms and legs, and allowing the user to exercise in water while a specific pressure is applied to restrict but not stop blood flow in the user's muscles. Appropriate restriction of blood flow to the user's muscles results in encouraging growth hormone secretion in the user and efficiently applying a load with less movement than that required on land, and the synergistic action of these two results makes it possible to increase muscle strength extremely easily.

Described herein are bioactive peptides that are modified at one or more positions with a PEG moiety. An example of such a PEGylated bioactive peptide is a GHRH analog that is modified at one or morepositions with a PEG moiety. Also described are pharmaceutically acceptable salts thereof and pharmaceutical compositions comprising such analogs or salts thereof, as well as methods, kits and uses thereof, for example for inducing or stimulating growth hormone secretion in a subject and for diagnosing, preventing or treating GH-deficient conditions in a subject.

The purpose of the present invention is to provide a growth hormone secretion promoter which has an excellent growth hormone secretion promoting effect and can be administered orally. This growth hormone secretion promoter contains at least one component selected from the group consisting of S-adenosylmethionine and / or a salt thereof, a Siberian larch extract, an olive extract and a stilbene compound as an active ingredient. S-Adenosylmethionine and / or a salt thereof may be contained in a chemically synthesized form thereof which is not modified in any way, or cells or a culture each containing S-adenosylmethionine and / or the salt thereof may be contained. The stilbene compound may be an extract from a plant belonging to the family Vitaceae or Gnetaceae. The olive extract may be an extract separated from an olive fruit.

The invention provides a γ-aminobutyric acid-producing Lactobacillus plantarum SG5, the Lactobacillus plantarum SG5 is preserved in the Guangdong Provincial Microbial Culture Collection Center, the preservation address is the Guangdong Provincial Institute of Microbiology, and the preservation date is March 16, 2016 Japan, the preservation number is GDMCC No: 60020; the content of GABA fermented by this bacteria can reach 59 μg / mL. GABA has many beneficial health functions such as lowering blood pressure, promoting growth hormone secretion and lowering cholesterol. The health food of γ-aminobutyric acid provides a basis, and the application of the Lactobacillus plantarum SG5 to the development of food and health products has broad application prospects.

The invention relates to a nutrition method for regulating sex hormone secretion of Cynoglossus semilaevis parent fishes, and belongs to the field of aquatic nutrition. The method is characterized in that different long-chain polyunsaturated fatty acid nutrients are supplied to the Cynoglossus semilaevis parent fishes at different gonad development stages and the parent fishes of different sexes. According to the method provided by the invention, the secretion of sex steroid hormones of the Cynoglossus semilaevis parent fishes can be precisely regulated at different stages for different sexes, the secretion of sex hormones can be promoted, and the breeding performance can be improved; the technology is based on the allocation of essential nutrients in Cynoglossus semilaevis parent fish feeds and high in operability; and the cost is in a controllable range, thereby achieving high economy.