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growth hormone secretion enhancer

A growth hormone and hormone-releasing technology, which is applied in the field of promoting the secretion of growth hormone-releasing hormone, can solve problems such as ineffective effects, and achieve the effect of promoting food intake

Active Publication Date: 2017-02-08
SNOW BRAND MILK PROD CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Also, since growth hormone or growth hormone-releasing hormone is a protein, it is decomposed by enzymes in the digestive tract, so it is considered that it will not exert its effect even if it is directly ingested orally.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] After fully washing the column (diameter 5 cm x height 30 cm) filled with 400 g of cation exchange resin-sulfonated CHITO PEARL (manufactured by Fuji Textile Co., Ltd.) with deionized water, make 40 L of skim milk (pH 6.7) at a flow rate of 25 ml / min through the column. After washing, the column was fully washed with deionized water, and the basic protein fraction adsorbed on the resin was eluted with 0.02M carbonic acid buffer solution (pH 7.0) containing 0.98M sodium chloride. The eluate was desalted with a reverse osmosis (RO) membrane, concentrated and freeze-dried to obtain 21 g of milk-derived basic protein fraction powder as an active ingredient of the growth hormone secretion promoter of the present invention.

experiment example 1

[0020] [Experimental Example 1] The basic protein fraction obtained in Example 1 was measured by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), and its molecular weight distribution was in the range of 3,000 to 80,000.

experiment example 2

[0021] [Experimental Example 2] The component composition of the milk-derived basic protein fraction obtained in Example 1 was analyzed. The results are shown in Table 1. As shown, the fractions are essentially protein.

[0022] [Table 1]

[0023]

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PUM

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Abstract

A growth hormone secretion promoter mediated by a growth hormone-releasing hormone secretion-promoting action using a milk-derived basic protein fraction as an active ingredient, and a growth hormone-promoting agent using a milk-derived basic protein fraction Methods of releasing hormone secretion. This growth hormone secretion promoter can be ingested daily, and has high safety even after long-term ingestion.

Description

technical field [0001] The present invention relates to a growth hormone secretion promoter which uses milk-derived basic protein fraction as an active ingredient. The present invention also relates to a growth hormone secretion promoting agent containing milk-derived basic protein fraction as an active ingredient, wherein the growth hormone secretion promotion is mediated by growth hormone releasing hormone secretion promotion. In addition, the present invention also relates to a method for promoting the secretion of growth hormone releasing hormone by using milk-derived basic protein fraction. Background technique [0002] Growth hormone has growth-associated and metabolic-controlling effects. Growth-related effects include: enhancing cell division in target organs, elongating bones, elongating bones by replacing cartilage tissue at bone ends with bone tissue, promoting the uptake of specific amino acids, and thus participating in muscle development that promotes protein ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/00A61P5/06
CPCA23L2/52A23L2/66A61K38/018A23L33/19A61P43/00A61P5/00A61P5/02A61P5/06A61K35/20A61K38/40
Inventor 小野爱子松山博昭森田如一芹泽笃日暮聪志
Owner SNOW BRAND MILK PROD CO LTD
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