3 results about "Somatropin" patented technology

The presently disclosed subject matter provides for in vitro methods of inducing differentiation of stem cells (e.g., human stem cells) into somatotrophs, and differentiated cells generated by such methods. The presently disclosed subject matter also provides for uses of such cells for treating growth hormone deficiency.

The present application relates to a kind of high drug loading density somatostatin oral nanoparticles, the nanoparticles are spherical hydrophobic polyester material as carrier, several hydrophobic somatostatin ion pair complex particles are uniformly wrapped inside, and hydrophilic hydroxyethyl starch is grafted on the outer surface of polyester material, wherein the hydrophobic somatostatin ion pair complex is composed of somatostatin and counterion compound, and the counterion compound is at least one of sodium dodecyl sulfate, 8- (2-hydroxybenzamide) sodium octanoate, sodium oleate, sodium octanoate, sodium caprate, sodium laurate, sodium dodecyl sulfonate, sodium dioctyl sulfosuccinate;The hydrophobic polyester material is lactic acid-glycolic acid copolymer, polycaprolactone, polylactic acid.The nanoparticles are modified by hydroxyethyl starch, can quickly penetrate mucus barrier during oral delivery, and have high enterocyte penetration efficiency, can effectively improve the oral bioavailability of somatostatin.

The invention discloses a freeze-drying method of a product for pharmaceutical, cosmetic or medical beauty application, which comprises the following steps of: adding a middle plug into a double-cavity clamping type bottle, filling a product to be freeze-dried, and placing and fixing the double-cavity clamping type bottle on a freeze-drying bracket; the top plug is limited on a bottle opening of the double-cavity clamping bottle; performing freezing, primary drying and secondary drying on the to-be-freeze-dried product respectively; and the top plug is fixed by the top cover and the bottle opening is sealed. According to the freeze-drying method provided by the invention, high-quality freeze-drying parameters and freeze-drying operation can be provided, so that the top plug and the top cover are utilized to complete integrated plug pressing and cover sealing of the double-cavity cassette bottle, the obtained growth hormone freeze-drying preparation for the growth culture can keep higher quality, the use effect of the freeze-drying preparation is improved, and the storage time of the freeze-drying preparation is prolonged.