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Ghrelin production promoter

a technology of ghrelin and promoter, which is applied in the field of new pharmaceuticals, can solve the problems that only a few substances have been known capable of promoting the production of ghrelin in living bodies, and achieve the effects of effective increase the production of acylated active ghrelin, excellent safety profile and effective treatmen

Inactive Publication Date: 2009-02-26
HOKKAIDO UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0013]According to the invention, it is possible to provide a pharmaceutical, which may effectively increase the production of acylated active ghrelin and be an effective treatment for patients with disorders associated with growth hormone deficiency or depression such as dwarfism, central nerve disorders such as Alzheimer's disease, and cardiac disorders such as myocardial infarction.
[0014]The pharmaceutical of the invention has an excellent safety profile with few problems such as side effects, since the active ingredient Rikkunshi-to has been used traditionally as a prescription drug in Japan and China.

Problems solved by technology

However, few substances have heretofore been known capable of promoting ghrelin production in living bodies.

Method used

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  • Ghrelin production promoter

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0049]Production of Rikkunshi-to extract:

[0050]Cut crude drugs—4 kg ATRACTYLODIS LANCEAE RHIZOMA, 4 kg GINSENG RADIX, 4 kg PINELLIAE TUBER, 4 kg POLIA, 2 kg ZIZYPHI FRUCTUS, 2 kg AURANTII NOBILIS PERICARPIUM, 1 kg GLYCYRRHIZAE RADIX and 0.5 kg ZINGIBERIS RHIZOMA—were taken, blended, and added to about 12 volumes of pure water. Then, the mixture was heated up to 95 or 100° C. under stirring. Thereafter, this was extracted for 60 minutes and the extract was processed for solid-liquid separation; then, the separated liquid was concentrated under reduced pressure. The concentrate was mixed with sucrose fatty acid ester added to a final concentration of 1.0% of the solid content of the extract, and dried by spraying to obtain a dried powder extract of Rikkunshi-to, 4.04 kg.

example 2

[0051]Production of granules:

[0052]Lactose (3.4225 kg) and magnesium stearate (0.0375 kg) were added to and mixed with the dried powder extract of Rikkunshi-to (4.04 kg) obtained in Example 1. The mixture was tabletted using a tabletting machine according to conventional methods, and then pulverized, granulated and sieved to obtain good granules.

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Abstract

The objectives are to find a substance or a composition capable of promoting the production of ghrelin with physiological activities such as growth hormone secretion effect, and to provide a pharmaceutical comprising it as the active ingredient. The pharmaceutical is a ghrelin production promoter comprising Rikkunshi-to as the active ingredient.

Description

TECHNICAL FIELD[0001]The present invention relates to a novel pharmaceutical such as ghrelin production promoter comprising “Rikkunshi-to” (a kind of kampo medicine) as the active ingredient.BACKGROUND ART[0002]Ghrelin is a peptide hormone discovered in 1999 that is known to promote the secretion of growth hormone (GH). Ghrelin promotes GH secretion via receptors different from those for growth hormone-releasing hormone (GHRH). The peptide chain of ghrelin comprises 28 amino acid residues, in which the hydroxyl group of the third serine is acylated with octanoic acid (active ghrelin); but non-acylated ghrelin (desacyl ghrelin) does not exhibit GH secretion activity.[0003]Various physiological active mechanisms of ghrelin are known; and for example, ghrelin is known to increase appetite, protect the cardiovascular system, and control metabolism among other effects, in addition to the above-mentioned GH secretion-promoting effect. These known effects of ghrelin suggest that the possib...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61P25/28A61P9/10A61P11/00
CPCA61K36/07A61K36/23A61K36/28A61K36/48A61K36/75A61K2300/00A61P11/00A61P25/28A61P5/00A61P5/10A61P9/00A61P9/10
Inventor ASAKA, MASAHIROTAKEDA, HIROSHITAKASAKI, RYUUJIHATTORI, TOMOHISA
Owner HOKKAIDO UNIVERSITY
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