The present invention relates to a method comprising administering to a patient diagnosed as being in need of treatment for nausea, emesis, or symptoms associated therewith comprising administering to a patient in need thereof a compound of formula (I)
wherein:
R1 is C6H5CH2OCH2—, C6H5(CH2)3— or indol-3-ylmethyl;
Y is pyrrolidinyl, 4-methyl-piperidinyl or NR2R2;
R2 are each independently C1-C6 alkyl;
R3 is 2-napthyl or phenyl para-substituted by W;
W is H, F, CF3, C1-C6 alkoxy or phenyl; and
R4 is H or CH3; or a pharmaceutically acceptable salt or solvate thereof, in an amount that is effective in treating nausea, emesis, or symptoms associated therewith in said patient.