47 results about "Postoperative ileus" patented technology

Methods of preventing and treating gastrointestinal dysfunction, particularly postoperative ileus and post-partum ileus, in a patient undergoing surgery or other biological stress by administering 4-aryl-piperidine derivatives are disclosed.

The present invention provides novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors according to formula (I) that are useful in the treatment or prophylaxis of physiological and/or pathophysiological conditions in mammals, preferably humans, that are mediated by GHS receptors. The present invention further provides GHS receptor antagonists and agonists that can be used for modulation of these receptors and are useful for treating above conditions, in particular growth retardation, cachexia, short-, medium- and/or long term regulation of energy balance; short-, medium- and/or long term regulation (stimulation and/or inhibition) of food intake; adipogenesis, adiposity and/or obesity; body weight gain and/or reduction; diabetes, diabetes type I, diabetes type II, tumor cell proliferation; inflammation, inflammatory effects, gastric postoperative ileus, postoperative ileus and/or gastrectomy (ghrelin replacement therapy).

Described herein are compositions and methods for intravenous administration of acetaminophen at a single dose level of less than about 1000 mg for the treatment or prevention of pain (e.g., postoperative pain) and/or fever.

There are provided novel 4-(2-furoyl)aminopiperidines represented by the general formula (I), their synthetic intermediates, processes for their preparation and medicaments containing them.

In the above formula, X is CH or N, and Y is a group of the following general formula (II), formula (II-a) or formula (III):

wherein a, b and c are each an integer of 0-6;

• [0001]
  • Z is CH₂ or NH; W is O or S;
  [0002]
  • T is O or N—R¹⁵ wherein R¹⁵ is H, a C1-C6 alkyl group, a benzyl group or a phenethyl group; and
  [0003]
  • R¹ is H, a C1-C6 alkoxycarbonyl group, a benzyloxycarbonyl group, or the like. The 4-(2-furoyl)aminopiperidine derivatives according to this invention possess opioid μ antagonistic activity and are useful for the treatment or prevention of side effects which are caused by μ receptors agonist and which are selected from constipation, nausea/emesis or itch, or for the treatment or prevention of idiopathic constipation, postoperative ileus, paralytic ileus, irritable bowel syndrome or chronic pruritus.

The present invention provides novel triazole derivatives with improved receptor activity and bioavailability properties as ghrelin analogue ligands of growth hormone secretagogue receptors according to formula (I) that are useful in the treatment or prophylaxis of physiological and/or pathophysiological conditions in mammals, preferably humans, that are mediated by GHS receptors. The present invention further provides GHS receptor antagonists and agonists that can be used for modulation of these receptors and are useful for treating above conditions, in particular alcohol disorder, drug abuse, growth retardation, cachexia, short-, medium-, and/or long term regulation of energy balance, short-, medium-, and/or long term regulation (stimulation and/or inhibition) of food intake, intake of rewarding food, adipogenesis, adiposity and/or obesity, body weight gain and/or reduction, diabetes, diabetes type I, diabetes type II, tumor cell proliferation, inflammation, inflammatory effects, gastric postoperative ileus, postoperative ileus and/or gastrectomy (ghrelin replacement therapy).

The invention discloses a postoperative care and rehabilitation device for the neurosurgery department. The postoperative care and rehabilitation device comprises a base plate, a control switch and anelectric heater are installed on the upper surface of the base plate, the input end of the control switch is electrically connected with the output end of an external power source, and the output endof the control switch is electrically connected with the input end of the electric heater. The postoperative care and rehabilitation device for the neurosurgery department is simple in structure, thelegs are supported through first hinging plates and second hinging plates, so that the legs are bent and uplifted, and the stability is high; first swing arms and second swing arms turn over throughfixed gears and fixed racks, and the control is convenient; electromagnetic massage devices can massage the soles, the plantar nerves are stimulated, and through the cooperation of bending and upliftof the legs, the legs and the brain nerves are activated and stimulated, and thus postoperative restoration is facilitated; heating pads can heat the legs, and have a certain heat preservation effect;meanwhile, the postoperative care and rehabilitation device makes cells of the legs active, is convenient to install and use as a whole, and lowers the working intensity of medical staff.

The invention relates to the field of nursing apparatuses for urinary surgery, in particular to a postoperative nursing binding sleeve for the urinary surgery. The binding sleeve comprises a front fixed ring and a rear fixed ring, wherein telescopic rods are distributed between the front and rear fixed rings in a circumferential direction; each telescopic rod comprises a fixed rod which is fixed to the rear fixed ring and a movable rod fixed to the front fixed ring; a gauze sleeve is fixedly arranged at the inner sides of the movable rods; a shield is connected to the front fixed ring by virtue of a screw thread; a urine outlet is formed in the shield; and the urine outlet is connected to a urine bag by virtue of a soft hose. The gauze sleeve provided by the invention is reliably fixed and is prevented from becoming fallen; through the adjusting and protecting effects of the telescopic rods, the phenomenon of painful erection can be prevented; and a patient can urinate conveniently, without causing pollution to the gauze sleeve.

The present invention relates to a compound having a blocking effect against sodium ion channels, particularly Nav1.7, a preparation method thereof and use thereof. The compound represented by the Formula 1 or a pharmaceutically acceptable salt, hydrate, solvate or isomer thereof can be effectively used in the prevention or treatment of pains, for example, acute pain, chronic pain, pain from nervous disease, postoperative pain, migraine, arthralgia, neuropathy, nerve injury, diabetic neuropathy, neuropathic disease, epilepsy, arrhythmia, myotonia, ataxia, multiple sclerosis, irritable bowel syndrome, urinary incontinence, visceral pain, depression, erythromelalgia, paroxysmal extreme pain disorder (PEPD).

The invention discloses a drug for treatment and postoperative care of uterus myoma, and belongs to the field of traditional Chinese medicines. The effective constituents of the drug comprise the following raw materials in parts by weight: 70-90 parts of white atractylodes rhizome, 60-80 parts of angelica, 55-75 parts of codonopsis pilosula, 50-70 parts of fried schizonepeta spike, 45-60 parts ofcortex moutan, 40-55 parts of cassia twig, 35-50 parts of white paeony root, 30-45 parts of herba leonuri, 25-43 parts of ligusticum wallichii, 22-40 parts of peach kernel, 18-35 parts of rhizoma sparganii, 15-30 parts of raw rhubarb, 12-25 parts of curcuma zedoary, 8-20 parts of scutellaria baicalensis, 5-16 parts of poria cocos and 3-12 parts of radix cyathulae. According to the invention, the raw materials are reasonably mixed, the raw materials capable of promoting blood circulation to remove blood stasis, resolving hard lump, warming, activating meridian and tonifying vital energy and spleen are selected for pathogenic factors such as cold congealing stasis, spleen deficiency and damp obstruction, dried blood accumulation, uterus stasis and the like; the effects of finding a disease source by visiting and treating both symptoms and root causes are achieved by regulating the whole-body function and activating the immune system of a patient; and the drug has a very good treatment effect for intramural myoma, subserous myoma, submucous myoma and cervix myoma through clinic verification.

The invention relates to the technical field of medicines, in particular to an application of vitexin in preparation of a drug for treating postoperative pain. A medicinal preparation is generally used in an intraperitoneal injection mode, and also can adopt other drug delivery modes: after molding, acute (single time) drug delivery dosage is 1-10 mg/kg, and chronic (repeated times) drug delivery dosage is 3-10 mg/kg. According to the medicinal preparation, the postoperative pain can be effectively relieved with the adoption of both acute drug delivery and chronic drug delivery, sedative side effects are avoided, and tolerance and addiction are not observed.

The invention discloses special medical-purpose formula food for postoperative patients. The special medical-purpose formula food for the postoperative patients contains soybean peptide powder, whey protein, corn oligopeptides powder, pachymaran, royal jelly powder, isomalto-oligosaccharide, dextrin, xylitol, complex vitamins, complex minerals and essence. The special medical-purpose formula food for the postoperative patients can provide suitable nutrient substances (including protein, various vitamins and mineral elements and the like), energy and traditional herbal medicine effective components, replenish protein and other nutrients needed for increasing body metabolism, improve the body constitution of the patients and accelerate wound healing.

The invention discloses aerosol with effects of promoting blood circulation to remove meridian obstruction for postoperative patients. The aerosol comprises the following selected raw material medicines in parts by weight: 10-20 parts of Chinese Polyphaga, 10-20 parts of herba epimedii, 5-10 parts of red dates, 5-10 parts of peach kernel, 5-10 parts of astragalus, 8-12 parts of akebiaquinata, 8-15 parts of honeysuckle stem, 10-20 parts of rhizoma corydalis, 8-12 parts of safflower, 10-20 parts of honeysuckle, 5-10 parts of mint and 5-10 parts of aloe. The medicine materials have the effects of promoting qi to activate blood, dredging meridians and collaterals, strengthening the body resistance to eliminate pathogenic factors, conditioning the internal organs and dispersing blood stasis and relieving pain, normal qi and blood operation in the internal organs is promoted, the Yin and Yang of the human body are balanced, the body immunity and disease resistance of the body are restored and improved, the effects of treating the internal diseases from exterior and activating collaterals and eliminating thrombus are ingeniously achieved, and formation of deep venous thrombosis is effectively avoided.

The invention discloses a sea cucumber oligopeptide nutritional powder suitable for recovery of postoperative patients. The raw materials are calculated by dry weight, and the parts by weight are as follows: 1-8% of sea cucumber oligopeptide, 5-10% of soybean oligopeptide, and 8% of yam powder ‑15g, licorice powder 3‑6g, sealwort powder 6‑12g, whole milk powder 8‑15%, maltodextrin 10‑30%, vegetable fat powder 10‑20%, mushroom powder 6‑14%, carrot powder 8 ‑15%, fructooligosaccharide 5‑10%, pineapple powder 3‑8%, vitamin C 0.1‑1%, xylitol 3‑8%. The product of the present invention contains oligopeptide components that can be quickly absorbed by the human body. The oligopeptides are matched according to the needs of surgical patients according to the needs of surgical patients, and the oligopeptides are efficiently provided. protein. According to the same source of medicine and food, the combination of yam powder, licorice and sealwort can nourish qi and strengthen the spleen, nourish the lung and kidney, and regulate the physiological state of the postoperative patient.

The invention relates to a medical dressing and especially relates to a peritoneoscope care dressing for an anus disease. The peritoneoscope care dressing for the anus disease provided by the invention comprises a fixation assembly, a back lining layer and a hydrogel function layer, wherein the hydrogel function layer is disposed on the top of the back lining layer; the fixation assembly is disposed on the bottom of the back lining layer; and the hydrogel function layer is prepared through one technology or combination of multiple technologies among chemical synthesis, high-energy ray radiation and freezing-thawing cycling of a hydrophilic macromolecule chemical compound with the mass percent of 5-50% and water with the mass percent of 50-95%. The dressing has the advantages that the structure is simple; design is rational; use is convenient and rapid; design which satisfies a crissum physiological structure and a hip physiological structure of a human body is adopted; the dressing can be tightly attached to crissum skin; a proper heal environment is provided for an operative incision formed after an anus disease operation; wound healing can be promoted, and incision pains can be relieved; and a patient's heal quality can be increased.

The present invention relates to a method of treating a transient impairment of the motility of the gastrointestinal system resulting from postoperative ileus in a patient wherein said method includes the step of administering a therapeutically effective amount of a peptidyl analog of ghrelin to said patient.

The invention discloses an aerosol for a postoperative patient to promote blood circulation and remove obstruction in channels. The aerosol is prepared from the following active pharmaceutical ingredients in parts by weight: 10-20 parts of milkvetch roots, 10-20 parts of Chinese honeylocust spines, 10-20 parts of wild chrysanthemums, 10-20 parts of deep-fried largehead atractylodes rhizome, 5-10 parts of pangolin scales, 5-10 parts of peach seeds, 5-10 parts of leeches, 8-12 parts of akebia stems, 8-15 parts of pseudo-ginseng, 10-20 parts of myrrh, 8-12 parts of safflowers, 8-12 parts of corydalis bungeana turcz, 8-12 parts of suberect spatholobus stems, 8-12 parts of mongolian snakegourd roots, 5-10 parts of aloes and 3-5 parts of dried venom of toads. The active pharmaceutical ingredients for preparing the aerosol are well combined to take effects of clearing away heat and toxic materials, nourishing yin, removing obstruction in channels, tonifying qi, promoting blood circulation, eliminating dampness, activating pulse, removing blood stasis and relieving pain synergistically. The aerosol provided by the invention has the effects of improving the circulation environment of blood vessels below the waist of the patient in essence, can treat both symptoms and root causes and can be used for preventing and treating deep vein thrombosis of the postoperative patient. In addition, the aerosol is convenient to operate, is economical and practical, has no side effect, has a definite treatment effect and is worthy of clinical promotion and application.

Provided is a use of a compound capable of influencing, at least in part, an activity of a neural reflex pathway for the preparation of a medicament for altering the motility of the gastrointestinal tract. The medicament can be used for prophylaxis and/or treatment of hypomotility of the gastrointestinal tract. Preferably, generalized hypomotility occurring during postoperative ileus is prevented and/or treated by a medicament of the invention. In one aspect, the neural reflex pathway's activity is decreased by, at least in part, preventing stimulation of the pathway by an immunocyte, a macrophage and/or a mast cell. Activity can also be decreased by, at least in part, preventing immunocyte recruitment. A compound capable of, at least in part, influencing an activity of, for instance, a neural reflex pathway comprises an anti-ICAM-1 antibody, an anti LFA-1 antibody, and/or ketotifen. A pharmaceutical composition for prophylactic and/or therapeutic treatment of an individual against hypomotility of the gastrointestinal tract comprising a compound capable of, at least in part, decreasing a neural reflex pathway is also herewith provided.

The invention discloses a postoperative drug for chronic peptic ulcer and esophagitis syndrome. The drug is applied to the postoperative treatment of chronic peptic ulcer and esophagitis syndrome. The drug is characterized by being prepared from the following raw pharmaceutical materials in proportioning ratio by weight: litchi chinensis Sonn., lindernia ruellioides (Colsm.)Pennell, polygonum orientale L., radix platycodi, aeschynomene indica L., trachelospermum jasminoides (Lindl.) Lem., radix puerariae, paris polyphylla Sm., luffa cylindrica (L.) Roem., manis pentadactyla Linnaeus, hordeum vulgare L. and setaria italica (L.) Beauv.. Proved by clinical trials, the drug has the characteristics of low recurrence rate and high safety in the postoperative treatment of chronic peptic ulcer and esophagitis syndrome, so that the method is worthy of clinical application and popularization.

The invention discloses special nourishment for postoperative recovery. The nourishment is prepared from, by weight, 50-80 parts of compound collagen peptide powder, 10-30 parts of haematococcus candy pieces, 10-30 parts of cranberry candy pieces and 10-30 parts of beta-glucan candy pieces. The special nourishment for postoperative recovery is specifically used for recovery of postoperative patients, is easy to absorb, can improve immunity, can fully provide protein, vitamin and microelements required by postoperative recovery, and promotes human body recovery.

Methods of using a stimulator device in the treatment of: gastrointestinal disorders such as dysphagia, gastroesophageal reflux diseases, functional dyspepsia, gastroparesis, postoperative ileus, irritable bowel syndrome, constipation, diarrhea, fecal incontinence, nausea and vomiting; gastrointestinal obstruction or pseudo-obstruction; pain and/or discomfort related to visceral organs; eating disorders, such as obesity, binge eating, bulimia, anorexia, and chemotherapy-induced emesis or emesis of other origin are presented. The stimulator device generally includes a housing, at least two electrodes, and a pulse generator. The housing has an exterior surface and an interior surface defining a sealed interior space. The housing is constructed of bio-compatible materials and sized and shaped for transport through the gastrointestinal tract.