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Application of vitexin in preparation of drug for treating postoperative pain

A technology of vitexin and drugs, applied in the field of medicine, can solve problems such as addiction, adverse reactions, and tolerance, and achieve the effect of reducing postoperative pain and having no sedative side effects

Active Publication Date: 2015-12-23
苏州康纯医药科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] In order to solve the current problems of insufficient treatment of postoperative pain, low effectiveness of therapeutic drugs, large adverse reactions or tolerance and addiction, the present invention provides a new clinical application of vitexin, specifically in the preparation of Application of drugs in the treatment of postoperative pain

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  • Application of vitexin in preparation of drug for treating postoperative pain
  • Application of vitexin in preparation of drug for treating postoperative pain
  • Application of vitexin in preparation of drug for treating postoperative pain

Examples

Experimental program
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Effect test

Embodiment 1

[0029] The establishment of embodiment 1 mouse incision pain model

[0030] test methods:

[0031] The establishment method of mouse incision pain model refers to (PogatzkiEM, RajaSN. Amouse model of incisional pain [J]. Anesthesiology, 2003, 99 (4): 1023-27. ): 1336-44.), the specific establishment method: using an anesthesia machine, after the mice were induced anesthetized with 3% isoflurane, put on an anesthesia mask, maintained anesthesia with 1.5% isoflurane, fixed in supine position, the right hind foot of the mouse After aseptic treatment with 75% alcohol, cut the skin with a No. 11 scalpel blade from 0.2 cm close to the heel to the direction of the toe, make a 0.5 cm long longitudinal incision, pick out the fascia, and draw longitudinally in the center of the fascia open. After hemostasis by light pressure, a stitch was sutured at the midpoint of the incision with a single No. 6 nylon thread, and then the animal was put back into the cage until it woke up. The mice...

Embodiment 2

[0034] Embodiment 2 Vitexin sedative effect experiment

[0035] The autonomic activity test method refers to (ZhuQ, Sun, YH; YunXDetal. Antinociceptive effects of curcuminarat model of postoperative pain, Scientific Reports, 2014, 4:4932), specifically: use a tester for autonomic activity of mice (YLS-1B, Jinan Yanyi Technology Co., Ltd., China) , the instrument includes a control part and 4 cylindrical black plastic dark boxes (diameter 30cm, height 30cm), the mouse is put into the black plastic dark, and the light sensor is located at the center of the box cover for recording the number of autonomous activities of the mouse. The number of spontaneous activities of mice within 60 min was recorded.

[0036] Animal grouping: 48 male ICR mice; divided into 4 groups, namely the normal control group and vitexin 3mg / kg, 10mg / kg, 20mg / kg three dose groups, 12 in each group. The normal control group was given normal saline, and the remaining groups were injected intraperitoneally wi...

Embodiment 3

[0039] Example 3 Effect of Acute Administration of Vitexin 1~10mg / kg on Mechanical Pain Threshold of Incision Pain Model Mice

[0040] Grouping of animals: 60 ICR mice, divided into 5 groups; 12 in the vehicle group (given 0.5% CMC-Na); 12 vitexin 1, 3, 5.5, 10 mg / kg dose groups, 12 in each group (Note: administered by intraperitoneal injection, vitexin is configured by 0.5% CMC-Na).

[0041] All mice in each group underwent incision surgery, and the operation method was the same as above. The baseline value of PWT in each group was tested 24 hours after the operation (no drug was administered at this time). After administration, the PWT was tested every 30 minutes until the pain threshold returned to the postoperative baseline value. The method of measuring the pain threshold is the same as above. The result is as image 3 As shown, 24h after operation, the baseline value of mechanical pain threshold (expressed as 0min) was measured before administration, and then the mech...

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Abstract

The invention relates to the technical field of medicines, in particular to an application of vitexin in preparation of a drug for treating postoperative pain. A medicinal preparation is generally used in an intraperitoneal injection mode, and also can adopt other drug delivery modes: after molding, acute (single time) drug delivery dosage is 1-10 mg / kg, and chronic (repeated times) drug delivery dosage is 3-10 mg / kg. According to the medicinal preparation, the postoperative pain can be effectively relieved with the adoption of both acute drug delivery and chronic drug delivery, sedative side effects are avoided, and tolerance and addiction are not observed.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of vitexin in the preparation of medicine for treating postoperative pain. Background technique [0002] Pain is an unpleasant sensory and emotional experience associated with tissue damage or potential tissue damage. According to the priority of onset and the duration of the disease, it can be classified into acute pain and chronic pain. Postoperative pain (postoperative pain) belongs to acute pain (the course of the disease is generally less than 6 weeks), which is a complex physiological response of the body to the disease itself and tissue damage caused by surgery (Zhang Chuanhan. Guidelines for Clinical Pain Treatment [M]. Beijing: Chinese Medicine Science and Technology Press, 2008: 502). At present, postoperative pain is a difficult clinical problem. If acute postoperative pain is not handled properly, it will lead to a series of adverse consequences, su...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P29/00
Inventor 李俊旭朱清毛丽娜刘成鹏孙越华
Owner 苏州康纯医药科技有限公司
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