Growth hormone secretion promoter

A growth hormone and accelerator technology, applied in endocrine system diseases, pill delivery, food ingredients, etc., can solve the problems that growth hormone secretion enhancers fail to achieve the effect, and achieve a good growth hormone secretion promotion effect

Inactive Publication Date: 2015-09-23
LION CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] However, traditional growth hormone secretion enhancers failed to achieve the desired effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 and comparative example 1

[0108] In Example 1, tablets (9 tablets containing 80 mg of S-adenosylmethionine agent) in which S-adenosylmethionine-containing yeast was mixed were prepared as samples. In Comparative Example 1, a placebo tablet containing no S-adenosylmethionine-containing yeast was prepared as a sample. The S-adenosylmethionine-containing yeast was "Amii" (trade name) manufactured by Iwata Chemical Co., Ltd.

[0109] The components of the sample of Comparative Example 1 and the sample of Example 1 are shown in Table 1 below.

[0110] [Table 1]

[0111] Components (one dose: content of components in 9 tablets)

Example 1

Comparative example 1

The content of S-adenosylmethionine in yeast containing S-adenosylmethionine (mg)

80.0

0.0

Weight of S-adenosylmethionine-containing yeast (dry yeast) (mg)

1530.0

0.0

Excipient (crystalline cellulose) (mg)

270.0

1800.0

[0112] (Evaluation of Growth Hormone Secretion-Stimulating Effe...

Embodiment 2 and comparative example 2

[0124] Except having used the sample whose composition is shown in Table 2, the same test and evaluation as Example 1 were performed.

[0125] [Table 2]

[0126] Components (one dose: content of components in 9 tablets)

Example 2

Comparative example 2

The content of S-adenosylmethionine in yeast containing S-adenosylmethionine (mg)

40.0

0.0

Weight of S-adenosylmethionine-containing yeast (dry yeast) (mg)

765.0

0.0

Excipient (crystalline cellulose) (mg)

1035.0

1800.0

[0127] The rate of change in the amount of GH in the urine of each member of the group was calculated by formula (1), and the average value of the rate of change in the amount of GH in the urine of 13 people was 112.4%.

[0128] The results of Examples 1 and 2, and Comparative Examples 1 and 2 show that GH secretion of a living body can be effectively promoted by administering S-adenosylmethionine and / or its salt to the living body.

[0129] Th...

Embodiment 3、 Embodiment 4 and comparative example 3

[0141] Tablets mixed with grape extract were prepared as samples of Example 3. As a sample of Example 4, a tablet mixed with the extract of Matonia japonica was prepared. As a sample of Comparative Example 3, tablets containing placebos containing no grape extract and safflower extract were prepared. As the grape extract, VINEATROL 20M (trade name) manufactured by ACTICHEM was used. As the sage extract, sage resveratrol-20 (trade name) produced by YBF Co., Ltd. was used.

[0142] Each composition of the example sample and the comparative example sample of the growth hormone secretion promoter concerning this invention is shown in detail in Table 3 below.

[0143] [table 3]

[0144]

[0145]

[0146] (Effect Evaluation of Growth Hormone Secretion Promoter)

[0147] Let six adult men and women in the group ingest the sample of the above-mentioned Example 3 one hour before going to bed for 4 consecutive days, and measure the content of growth hormone in the initial urin...

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Abstract

The purpose of the present invention is to provide a growth hormone secretion promoter which has an excellent growth hormone secretion promoting effect and can be administered orally. This growth hormone secretion promoter contains at least one component selected from the group consisting of S-adenosylmethionine and / or a salt thereof, a Siberian larch extract, an olive extract and a stilbene compound as an active ingredient. S-Adenosylmethionine and / or a salt thereof may be contained in a chemically synthesized form thereof which is not modified in any way, or cells or a culture each containing S-adenosylmethionine and / or the salt thereof may be contained. The stilbene compound may be an extract from a plant belonging to the family Vitaceae or Gnetaceae. The olive extract may be an extract separated from an olive fruit.

Description

[0001] This application is a divisional application based on the following Chinese patent application: [0002] Application date of the original case: March 2, 2012 [0003] Original application number: CN201280004470.4 (PCT / JP2012 / 055361) [0004] Original application name: growth hormone secretion enhancer technical field [0005] The invention relates to a growth hormone secretion promoter. Specifically, it relates to a growth hormone secretion promoter containing S-adenosylmethionine as an active ingredient. Background technique [0006] Growth hormone (hereinafter sometimes abbreviated as GH) is secreted by the pituitary gland and is related to metabolism such as bone metabolism, protein metabolism, glucose metabolism, fat metabolism, and electrolyte metabolism. Inadequate secretion of growth hormone in childhood can lead to developmental disorders, and insufficient secretion of growth hormone in adulthood can become a risk factor for metabolic abnormalities and card...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/32A61K36/81A61K36/13A61K36/15A61K31/7076A61P5/06A23L1/29A23L2/38
CPCA61K36/63A61K36/17A61K9/4875A61K36/15A61K36/87A61K9/2054A61K31/05A61K31/7076A61K31/7048A61K36/06A61P43/00A61P5/00A61P5/06A61P5/10A61P9/00A23L33/105A61K31/015A23V2002/00A23V2200/30
Inventor 五木田智夫镰田育子铃木究上林博明
Owner LION CORP
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