Growth hormone secretion promoter

A growth hormone and accelerator technology, applied in endocrine system diseases, pill delivery, food ingredients, etc., can solve the problems that growth hormone secretion enhancers fail to achieve the effect, and achieve a good growth hormone secretion promotion effect

Active Publication Date: 2013-09-18
LION CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, traditional growth hormone secretion enhancers failed to achieve the desired effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 and comparative example 1

[0104] In Example 1, tablets containing S-adenosylmethionine-containing yeast (9 tablets containing 80 mg of S-adenosylmethionine agent) were prepared as samples. In Comparative Example 1, a placebo tablet containing no S-adenosylmethionine-containing yeast was prepared as a sample. The S-adenosylmethionine-containing yeast was "Amii" (trade name) manufactured by Iwata Chemical Co., Ltd.

[0105] The components of the sample of Comparative Example 1 and the sample of Example 1 are shown in Table 1 below.

[0106] [Table 1]

[0107] Ingredients (amount for one dose: content of ingredients in 9 tablets)

[0108] (Evaluation of growth hormone secretion promoting effect)

[0109] As a group, 13 adult males and females ingested the sample of the above-mentioned Example 1 one hour before going to bed, and measured the content of growth hormone in the first urine (morning urine) when they got up the next day. As in Example 1, 13 adult males and females were asked to inge...

Embodiment 2 and comparative example 2

[0120] Except having used the sample whose composition is shown in Table 2, the same test and evaluation as Example 1 were performed.

[0121] [Table 2]

[0122] Ingredients (amount for one dose: content of ingredients in 9 tablets)

[0123] The change rate of GH amount in urine of each member of the group was calculated by formula (1), and the average value of change rate of GH amount in urine of 13 people was 112.4%.

[0124] The results of Examples 1 and 2, and Comparative Examples 1 and 2 show that GH secretion of a living body can be effectively promoted by administering S-adenosylmethionine and / or its salt to the living body.

[0125] The following are formulation examples of various compositions (final products) using the growth hormone secretion promoter of the present invention. The S-adenosylmethionine-containing yeast used in the following formulation examples is "High SAMe dry yeast (trade name)" manufactured by Mitsubishi Gas Chemical Co., Ltd.

[0126...

Embodiment 3、 Embodiment 4 and comparative example 3

[0137] Tablets mixed with grape extract were prepared as samples of Example 3. As a sample of Example 4, a tablet mixed with the extract of Matonia japonica was prepared. As a sample of Comparative Example 3, tablets containing placebos containing no grape extract and safflower extract were prepared. As the grape extract, VINEATROL 20M (trade name) manufactured by ACTICHEM was used. As the extract of fennel, resveratrol-20 (trade name) produced by YBF Co., Ltd. was used.

[0138] Each composition of the example sample and the comparative example sample of the growth hormone secretion promoter concerning this invention is shown in detail in Table 3 below.

[0139] [table 3]

[0140]

[0141](Effect Evaluation of Growth Hormone Secretion Promoter)

[0142] Let six adult men and women in the group ingest the sample of the above-mentioned Example 3 one hour before going to bed for 4 consecutive days, and measure the content of growth hormone in the initial urine (morning ur...

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Abstract

The purpose of the present invention is to provide a growth hormone secretion promoter which has an excellent growth hormone secretion promoting effect and can be administered orally. This growth hormone secretion promoter contains at least one component selected from the group consisting of S-adenosylmethionine and / or a salt thereof, a Siberian larch extract, an olive extract and a stilbene compound as an active ingredient. S-Adenosylmethionine and / or a salt thereof may be contained in a chemically synthesized form thereof which is not modified in any way, or cells or a culture each containing S-adenosylmethionine and / or the salt thereof may be contained. The stilbene compound may be an extract from a plant belonging to the family Vitaceae or Gnetaceae. The olive extract may be an extract separated from an olive fruit.

Description

technical field [0001] The invention relates to a growth hormone secretion promoter. Specifically, it relates to a growth hormone secretion promoter containing S-adenosylmethionine as an active ingredient. Background technique [0002] Growth hormone (hereinafter sometimes abbreviated as GH) is secreted by the pituitary gland and is related to bone metabolism, protein metabolism, glucose metabolism, fat metabolism, electrolyte metabolism and other metabolism. Inadequate secretion of growth hormone in childhood can lead to developmental disorders, and insufficient secretion of growth hormone in adulthood can become a risk factor for metabolic abnormalities and cardiovascular disorders. Even in healthy people, growth hormone secretion gradually decreases with age. It is well known that compared with young people, the elderly are relatively in a state of insufficient secretion of growth hormone, and it has been pointed out that insufficient secretion of growth hormone lea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7076A61K36/06A61P5/10A61P43/00A23L2/38
CPCA61K36/06A61K36/87A61K36/15A61K36/63A61K9/2054A61K9/4875A61K31/7076A61P43/00A61P5/00A61P5/06A61P5/10A61P9/00A23L33/105A61K31/015A61K31/05A23V2002/00A23V2200/30A61K31/7048A61K36/17
Inventor 五木田智夫镰田育子铃木究上林博明
Owner LION CORP
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