Application of 4-methoxybenzyl alcohol in preparation of neuroprotective drugs

A technology of methoxybenzyl alcohol and neuroprotection, which is applied in the field of 4-methoxybenzyl alcohol in the preparation of neuroprotective drugs, and can solve the problems of unseen neuroprotection and the like

Inactive Publication Date: 2016-01-06
YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Soluble in alcohol and ether, almost insoluble in water, its chemical formula is: C 8 h 10 o 2 , the structural formula...

Method used

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  • Application of 4-methoxybenzyl alcohol in preparation of neuroprotective drugs
  • Application of 4-methoxybenzyl alcohol in preparation of neuroprotective drugs
  • Application of 4-methoxybenzyl alcohol in preparation of neuroprotective drugs

Examples

Experimental program
Comparison scheme
Effect test

experiment example 14

[0026] Effect of Experimental Example 14-Methoxybenzyl Alcohol on Neuronal Growth

[0027] 1 Experimental materials

[0028] 1.1 Experimental animals

[0029] SD rats, female and male, weighing 180±220 g, were provided by the Institute of Zoology, Sichuan Academy of Medical Sciences, certificate number: 0014842.

[0030] 1.2 Experimental reagents

[0031]

[0032] 1.3 Experimental Instruments

[0033]

[0034] 1.4 Preparation of reagents

[0035] 1.4.10.01% PLL solution

[0036] The 0.1% poly-lysine solution was diluted 10 times with sterile double-distilled water to prepare a 0.01% poly-lysine solution, and placed in a 4°C refrigerator for later use.

[0037] 1.4.2 D-Hanks solution

[0038] Add 0.5ml of double antibody to the D-Hanks solution to make the final concentration 10U / ml, and store in a refrigerator at 4°C.

[0039] 1.4.3 Termination of digestive juice

[0040] The DMEM culture medium and FBS were mixed at a ratio of 9:1 to prepare a DMEM culture mediu...

experiment example 24

[0110] Experimental Example 24-Methoxybenzyl Alcohol Antigen Substitutes the Effect of OGD / Rep Injury on Cortical Neurons

[0111]After cerebral ischemia, the respiration of nerve cells is blocked, and respiratory dysfunction causes mitochondrial dysfunction and affects the energy supply of brain cells; after reperfusion, while restoring oxygen supply, it can lead to a large number of free radicals and intracellular calcium overload , a large increase in reactive oxygen species (reactive oxygen species, ROS) beyond the superoxide dismutase (superoxide dismutase, SOD) and glutathione peroxidase (GSH-Px) defense scavenging capacity, excess ROS attack mitochondria The double bonds of unsaturated fatty acids in membrane phospholipids lead to lipid peroxidation, and the content of malondialdehyde (MDA) increases, further destroying the integrity of mitochondrial membranes, loss of cell function, and brain damage.

[0112] In this experiment, the high-purity cortical neuron obtained...

experiment example 34

[0175] Experimental Example 3: Effect of 4-methoxybenzyl alcohol on the expression of neuronal apoptosis-related proteins

[0176] In the process of cerebral ischemia-reperfusion injury, the death of nerve cells in the ischemic central area is mainly necrosis, while the nerve cells in the penumbra cannot maintain their normal physiological functions, but still have metabolic vitality, and their subsequent death is mainly apoptosis , in the process of nerve cell apoptosis, the mitochondrial apoptosis pathway is extremely important. Studies have shown that the activation of mitochondrial apoptotic pathway is the initiating factor of brain nerve cell apoptosis. After cerebral ischemia, nerve cell respiration is blocked, and respiratory dysfunction reduces ATP synthesis, mitochondrial dysfunction, and affects the energy supply of brain cells; After restoration of reperfusion, while oxygen supply is restored, it can lead to a large number of free radicals and intracellular calcium ...

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Abstract

The invention discloses application of 4-methoxybenzyl alcohol in preparation of neuroprotective drugs. 4-methoxybenzyl alcohol may reduce injury of primary cortical neurons OGD/Rep of fetal rats and neuron morphological structure injury and increase survival rate of OGD/Rep injured cortex; the release of OGD/Rep injured cortical neuron NO is reduced, activity of SOD (superoxide dismutase) in cells is improved, generation of MDA (methane dicarboxylic aldehyde) is inhibited, apoptosis of nerve cells may be inhibited through significant up-regulation of Bcl-2 protein expression and down-regulation of Bax protein and Caspase-3 protein expression, neuroprotective effect is good, neuroprotective drugs may be produced, and nerve injury is reduced; in addition, the 4-methoxybenzyl alcohol may promote synapse growth of nerve cells, up-regulate synapse growth related proteins, promote repair of the nerve cells and treat nerve injury.

Description

technical field [0001] The invention relates to the use of 4-methoxybenzyl alcohol in the preparation of neuroprotective drugs. Background technique [0002] The incidence rate of central nervous system diseases is relatively high, and the harm to patients is also relatively large. For example, stroke is a group of acute cerebrovascular diseases with sudden onset and common feature of focal neurological deficit, with a mortality rate of up to 10%, which seriously threatens human health. Neuroprotective agent therapy has become a research hotspot in the treatment of stroke. Many neuroprotective agents are currently in clinical development trials. Their mechanism of action is to prevent or limit ischemia by blocking the occurrence of various harmful pathological processes caused by ischemia. The resulting brain damage reduces brain tissue death and promotes functional recovery. Because neuroprotective agents can reduce the size of cerebral infarction, do not cause hemorrhage...

Claims

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Application Information

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IPC IPC(8): A61K31/085A61P25/00
Inventor 段小花李秀芳林青李艳
Owner YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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