A novel sesquiterpene compound and its preparation method and application

A compound and drug technology, applied in the field of novel sesquiterpene compounds and their preparation, can solve the problems of irreversibility and progressive aggravation, and achieve the effect of novel structure and protection of nerve cells

Active Publication Date: 2022-04-15
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

NDD is a major disease that seriously threatens the health of the elderly. It has two characteristics: irreversibility and progressive aggravation. At present, the main treatment for this kind of disease is to control and relieve symptoms, and it is still impossible to reverse the progress of the disease.

Method used

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  • A novel sesquiterpene compound and its preparation method and application
  • A novel sesquiterpene compound and its preparation method and application
  • A novel sesquiterpene compound and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] The preparation of embodiment 1 compound of the present invention

[0060] (1) Experimental materials:

[0061] ① Medicinal materials

[0062] Dendrobium nobile was purchased from Sichuan Wanan Dendrobium Industry Development Co., Ltd. (Chengdu), and was identified as the fresh stems and leaves of Dendrobium nobile Lindl. by Professor Zhang Tingmo of Chengdu University of Traditional Chinese Medicine.

[0063] ②Reagents and fillers

[0064] Automatic polarimeter (Shanghai Yili Scientific Instrument Co., Ltd.)

[0065] Perkin-Elmer spectrum one FT-IR infrared spectrometer (KBr tablet)

[0066] Chirascan CD spectrometer (Applied Photophysics, UK)

[0067] Bruker-600 nuclear magnetic resonance instrument (Germany Bruker company)

[0068] Waters Synapt G2 Tof-HDMS mass spectrometer (Waters, USA)

[0069] RE-52A rotary evaporator (Shanghai Yarong Instrument Biochemical Factory)

[0070] Silica G (Qingdao Ocean Chemical Factory)

[0071] GF254 Silica Gel Preparation...

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Abstract

The invention discloses the compound represented by formula (A), or its stereoisomer, or its salt, or its solvate, or its prodrug, or its metabolite. The test results show that the sesquiterpene compound provided by the invention can effectively protect nerve cells, and its protective effect is even better than that of the positive control drug. Therefore, the sesquiterpene compound provided by the present invention, or its stereoisomer, or its salt, or its solvate, or its prodrug, or its metabolite is used in the preparation of neuroprotective drugs, especially in the preparation of preventive and / Or in medicines for the treatment of neurodegenerative diseases, it has a good application prospect. The invention provides a new option for clinically screening and / or preparing neuroprotective drugs.

Description

technical field [0001] The invention belongs to the field of medicine preparation, and in particular relates to a novel sesquiterpene compound and its preparation method and application. Background technique [0002] Dendrobium nobile (Dendrobium nobile) is listed as one of the main sources of Dendrobium medicinal materials. It has a long history of medicinal use. The effect of nourishing yin and clearing heat can be used to treat diseases such as febrile disease, body fluid injury, thirsty tongue, and post-illness deficiency heat. It is known as "life-saving celestial grass" among the people. Modern pharmacological research has found that Dendrobium nobile has obvious effects in improving the body's immunity, anti-tumor, and neuroprotection. Phytochemical studies have shown that Dendrobium nobile contains a large amount of sesquiterpenes (including sesquiterpene alkaloids) and stilbenes (bibenzyl and phenanthrene) components, other components such as phenols, steroids, fla...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D493/08A61K31/366A61P25/28A61P25/16A61P25/14A61P21/00
CPCC07D493/08A61P25/28A61P25/16A61P25/14A61P21/00
Inventor 熊亮彭成周勤梅郭力马川蒙春旺
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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