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40 results about "Mitochondrial biogenesis" patented technology
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Mitochondrial biogenesis is the process by which cells increase mitochondrial mass. It was first described by John Holloszy in the 1960s, when it was discovered that physical endurance training induced higher mitochondrial content levels, leading to greater glucose uptake by muscles. Mitochondrial biogenesis is activated by numerous different signals during times of cellular stress or in response to environmental stimuli, such as aerobic exercise.
Compositions and methods for modulating metabolic pathways
ActiveUS20130017283A1Increasing sirtuin-pathway outputIncrease productionBiocideHydroxy compound active ingredientsIsocaproic acidFatty acid
Compositions and methods useful for inducing an increase in fatty acid oxidation or mitochondrial biogenesis, reducing weight gain, inducing weight loss, or increasing Sirt1, Sirt3, or AMPK activity are provided herein. Such compositions can contain synergizing amounts of a sirtuin-pathway activators, including but not limited to resveratrol, in combination with beta-hydroxymethylbutyrate (HMB), keto isocaproic acid (KIC), leucine, or combinations of HMB, KIC and leucine.
Owner:NUSIRT SCI
Compositions and methods for the prevention and treatment of diseases or conditions associated with oxidative stress, inflammation, and metabolic dysregulation
InactiveUS20130273175A1Positively ratePositively efficiencyBiocideNervous disorderDiseaseOxidative stress
The present invention relates to methods and formulations for the prevention or treatment of diseases or conditions associated with oxidative stress, inflammation, and metabolic dysregulation. Specifically, the present invention comprises compositions and methods that increase mitochondrial biogenesis, alleviate inflammation, and increase the level of endogenous enzymatic and non-enzymatic antioxidants in a subject.
Owner:FINLEY JAHAHREEH
Compositions and methods for modulating metabolic pathways
ActiveUS20130017284A1Increasing sirtuin-pathway outputIncrease productionBiocideHydroxy compound active ingredientsIsocaproic acidFatty acid
Compositions and methods useful for inducing an increase in fatty acid oxidation or mitochondrial biogenesis, reducing weight gain, inducing weight loss, or increasing Sirt1, Sirt3, or AMPK activity are provided herein. Such compositions can contain synergizing amounts of a sirtuin-pathway activators, including but not limited to resveratrol, in combination with beta-hydroxymethylbutyrate (HMB), keto isocaproic acid (KIC), leucine, or combinations of HMB, KIC and leucine.
Owner:NUSIRT SCI
Compositions and methods for modulating metabolic pathways
ActiveUS8617886B2Increase productionIncreases mitochondrial biogenesisHydroxy compound active ingredientsPeptide/protein ingredientsWeight decreasingTert-leucine
Owner:NUSIRT SCI
Exersomes, methods of producing and method of using
An exosome pellet or physiological solution comprising resuspended exosomes is provided. The exosomes are essentially free from undesirable particles having a diameter less than 20 nm or greater than 140 nm, and the exosomes comprise one or more metabolic products. The exosomes may be used to induce mitochondrial biogenesis, increase thermogenesis (browning) of subcutaneous white adipose tissue, and / or mediate other systemic effects of exercise in a mammal.
Owner:EXERKINE
Bronchial smooth muscle remodeling involves calcium-dependent enhanced mitochondrial biogenesis in asthma
InactiveUS20090318413A1Prevent proliferationInhibit expressionBiocideAnimal repellantsSmooth muscleMedicine
The present invention thus provides a method of inhibiting bronchial smooth muscle remodeling in asthma, comprising the step of administering to a subject having asthma an agent that inhibits calcium-dependent mitochondrial biogenesis.
Owner:UNIV VICTOR SEGALEN BORDEAUX 2
Methods for inducing mitochondrial biogenesis
Methods and compositions for inducing mitochondrial biogenesis are provided. In some aspects, methods for the treatment of diseases such as acute kidney disease (AKI) or a muscle wasting disease by administering tomoxetine, nisoxetine, fenoterol, formoterol, or procaterol to an individual are provided.
Owner:MUSC FOUND FOR RES DEV
Nutritional approach to improving athletic performance and reducing injury with l-ergothioneine and/or vitamin d2
InactiveUS20150157648A1Improve muscle functionHigh strengthBiocideOrganic active ingredientsNutritional approachesAntioxidant
Nutritional products, compositions, functional ingredients, medical foods, pharmaceutical preparations and methods of use are disclosed for support and improvement of athletic performance (strength, flexibility, endurance, balance, and conditioning), and prevention and repair of injuries, including improving or maintaining muscle mitochondrial health, stimulating muscle mitochondrial biogenesis as well as other indications as set forth herein. In addition, pharmaceutical, nutraceutical and nutritional medical food compositions that are useful in conditions, normal or abnormal, associated with mitochondrial dysfunction and altered biogenesis in organ systems consisting of skeletal muscle, smooth muscle and cardiac muscle are also disclosed. L-Ergothioneine (also referred to as Ergothioneine or ET), Vitamin D2 (Ergocalciferol) and / or other antioxidants are disclosed for use in pharmaceutical, nutraceutical and nutritional medical food compositions for uses to stimulate production of bioactive molecules, including but not limited to glutathione, alpha synuclein, and IL-6.
Owner:ENTIA BIOSCI
Compositions and methods for the prevention and treatment of diseases or conditions associated with oxidative stress, inflammation, and metabolic dysregulation
InactiveUS8652518B2Reduce oxidative stressFunction increaseBiocideNervous disorderDiseaseAntioxidant
Owner:FINLEY JAHAHREEH
Methods and compositions for treatment of ischemic conditions and conditions related to mitochondrial function
InactiveCN102480951ASimple structureFunction increaseBiocideNervous disorderDiseaseMitochondrial depletion
The present invention relates to compositions and methods for prophylactic and / or therapeutic treatment of conditions related to mitochondrial function. In various aspects, the present invention comprises administering one or more compounds selected from the group consisting of epicatechin, an epicatechin derivative, catechin, a catechin derivative, nicorandil, and a nicorandil derivative in an amount effective to stimulate mitochondrial function in cells. The methods and compositions described herein provide for reducing infarct size in the heart following permanent ischemia or ischemia / reperfusion (IR) event or method for delaying, attenuating or preventing adverse cardiac remodeling, and can assist in prevention of impaired mitochondria biogenesis and thus prevention of the consequences of impaired mitochondrial biogenesis in various diseases and conditions, as well as provide for the active therapy of mitochondrial depletion that may have already occurred.
Owner:CARDERO THERAPEUTICS
Mito-Ob: A Transgenic Mouse Model for Obesity
An obese mouse model was developed by overexpressing the mitochondrial protein prohibitin (PHB) in white adipose tissue (WAT) specific manner driven by adipocyte protein 2 (aP2) promoter. These mice begin to develop obesity as a result of mitochondrial remodeling (upregulation of mitochondrial biogenesis and function) in WAT.
Owner:UNIVERSITY OF MANITOBA
LIPOSOMAL REDUCED GLUTATHIONE AND l-ARGININE, INCLUDING WITH OTHER INGREDIENT(S), CAPABLE OF MULTIPATH ADMINISTRATION FOR REVERSAL AND PREVENTION OF OBESITY AND FOR MITOCHONDRIAL BIOGENESIS
InactiveUS20120219616A1Reduce productionReduce weightBiocideOrganic active ingredientsArginineAdditive ingredient
The invention enables management of mammalian disease related to decreased energy production in the mitochondria by a combination of liposomal reduced glutathione and 1-arginine. For individuals whose inability to lose weight is related to inefficiency of the biochemical pathways facilitating mitochondrial function and energy production, the invention proposes to assist in weight loss by improving the inefficient production of energy by the respiratory transport chain of mitochondria. The invention is useful for the management of the metabolic syndrome, a group of metabolic factors associated with an increased risk of vascular disease problems. The invention is also useful for the resolution of fatigue that accompanies both weight gain and illnesses. The ability of the invention to increase the production of the biochemical agmatine in the central nervous system as well as generally in the body is part of the benefit of the combination of liposomal reduced glutathione and 1-arginine.
Owner:YOUR ENERGY SYST
Hydroxytyrosol benefits mitochondria
InactiveUS20110112201A1Improve production efficiencyIncrease capacityBiocideHydroxy compound active ingredientsHydroxytyrosolLiver tissue
Hydroxytyrosol or olive juice containing hydroxytyrosol can be used to maintain or increase mitochondrial biogenesis in cardiac muscle, skeletal muscles, and liver tissue.
Owner:DSM IP ASSETS BV
Compositions and Methods of Use of -hydroxy--methylbutyrate (HMB) for Decreasing Fat Mass
InactiveUS20160346238A1Fat lossLose weightMetabolism disorderAntipyreticIncreased LipolysisWhole body
The present invention provides a composition comprising HMB. Methods of administering HMB to an animal are also described. HMB is administered to enhance or promote lipolysis, increase adipocyte fat oxidation, induce adipocyte and muscle mitochondrial biogenesis, increase energy expenditure, decrease total body weight and increase body fat loss.
Owner:METABOLIC TECH
Bioactive alkaloid compositions and their medical uses
ActiveUS20150018292A1Increase painReduced joint mobilityBiocideSaccharide with carbocyclic radicalsDyslipidemiaMuscle dysfunction
The present invention relates to a novel alkaloid and novel bioactive alkaloid fractions derivable from Ribes preferably selected among Ribes Rubrum and Ribes nigrum; methods of manufacturing such bioactive Ribes alkaloid fractions and their use for the inhibition of IKK-β, PDE4 and / or PDE5 and in addition their promoting effect on mitochondrial biogenesis and function; their therapeutic or non-therapeutic applications as nutritive or medicinal products in the management of conditions associated with impaired mitochondrial function or IKK-β, PDE4 and / or PDE5 activity, such as inflammation, neurodegeneration, dyslipidemia, type 2 diabetes mellitus, impaired wound healing, sarcopenia and other conditions associated with muscle dysfunction or tiredness and fatigue, or where optimization of muscular or cognitive function is desired; extracts, juices or concentrates of Ribes comprising such alkaloids; compostions comprising such alkaloids, including pharmaceutical compositions, nutritive product such as functional foods and nutraceutical compositions, and cosmetic compositions and medical devices.
Owner:ASIROS
Hydroxytyrosol combinations for enhancing mitochondrial function and energy production
InactiveUS20120225840A1Increase mtDNA expressionRaise the ratioBiocideVitamin food ingredientsHydroxytyrosolB vitamins
Hydroxytyrosol or olive juice containing hydroxytyrosol in combination with at least one of the compounds selected from the group consisting of: creatine, coenzyme Q10, resveratrol, caffeine, carnitine, B vitamins (B1, B2, B3, B5, B6, and / or B12) and ginseng (preferably: root) extract can be used to maintain or increase mitochondrial biogenesis in cardiac muscle, skeletal muscles, and liver tissue.
Owner:DSM IP ASSETS BV
Co-releasing compounds & formulations thereof useful for inducing mitochondrial biogenesis and tissue repair
InactiveUS20160243151A1Promote repairPromote tissue growthDigestive systemDead animal preservationTissue repairCo release
Provided are pharmacological methods of inducing through a unified set of molecular mechanisms the maturation of stem cells, methods of promoting mitochondrial biogenesis in a cell and tissue, methods of reducing pluripotency in a stem cell, and methods of promoting differentiation of a stem cell. In particular, the invention relates to methods for promoting tissue growth and / or tissue repair and / or improving tissue survival, preventing and treating fibrotic lesions and disorders.
Owner:UNIV ZURICH +1
Compositions and methods for increasing energy metabolism
ActiveUS9943517B2To promote metabolismReduce weightHydroxy compound active ingredientsMetabolism disorderMetaboliteFatty acid
Owner:NUSIRT SCI
Hydroxytyrosol combinations for enhancing mitochondrial function and energy production
Hydroxytyrosol or olive juice containing hydroxytyrosol in combination with at least one of the compounds selected from the group consisting of: creatine, coenzyme Q10, resveratrol, caffeine, carnitine, B vitamins (B1, B2, B3, B5, B6, and / or B12) and ginseng (preferably: root) extract. can be used to maintain or increase mitochondrial biogenesis in cardiac muscle, skeletal muscles, and liver tissue.
Owner:DSM IP ASSETS BV
Method for measuring mitochondrial membrane potential in vertebrate cells
InactiveUS20100209960A1Improve mitochondrial functionMicrobiological testing/measurementMaterial analysisMitochondrial Uncoupling ProteinsHigh-Throughput Screening Methods
The present invention relates to homogenous fluorescence-based assays for measuring mitochondrial membrane potential in vertebrate cells. The assays use an inner filter such as Brilliant Black BN to quench non-specific fluorescence. The assays are particularly suited for ultra high-throughput screening for activators of mitochondrial uncoupling proteins, chemical uncouplers, compounds with mitochondrial toxicity, and compounds which stimulate mitochondrial biogenesis.
Owner:MERCK SHARP & DOHME CORP
Polytherapy modulating cathelicidin gene exprtession modulation for the treatment of alzheimer's disease and other conditions
InactiveUS20190015361A1Promotes bacterial phagocytosisHigh expressionNervous disorderHydroxy compound active ingredientsCellular AgingCvd risk
A polytherapy of orally available compounds is disclosed that synergistically modulates and induces the expression of the cathelicidin gene (CAMP), which encodes the host defense peptide LL-37. By providing a number of different CAMP-inducing compounds together at the same time, stronger gene induction is achieved than with just one or two compounds, because the mechanism of induction broadens. Induction also may vary in different parts of the body depending on which compounds are used, and at what levels. We show for the first time that the polytherapy can induce cathelicidin expression in the brain, which may help to treat or prevent Alzheimer's Disease. Systemic cathelicidin gene induction may help treat numerous other conditions including Type 2 Diabetes / Metabolic Syndrome, or chronic bacterial, viral, or fungal infections associated with increased cancer risk or neurodegeneration. By increasing cellular autophagy and macroautophagy and supporting mitochondrial biogenesis and homeostasis, CAMP gene upregulation may reduce the effects of cellular aging and increase longevity.
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV +1
Bioactive alkaloid compositions and their medical uses
ActiveUS9023816B2Strong promotion effectStrong wound healing propertiesBiocideSaccharide with carbocyclic radicalsDyslipidemiaFruit juice
Owner:ASIROS
Composition and method for inducing EPO-mediated haemoglobin expression and mitochondrial biogenesis in nonhaematopoietic cell
InactiveUS20160008386A1Stimulates Hb expressionHigh affinityBiocideCarbohydrate active ingredientsHematopoietic cellRed blood cell
Owner:NATIONAL YANG MING UNIVERSITY
Composition for promoting skeletal muscle activity via induction of mitochondrial biogenesis comprising of azelaic acid as an active ingredient
PendingUS20200397733A1Increasing mitochondrial densityPrevent muscle agingMuscular disorderNeuromuscular disorderFood materialBULK ACTIVE INGREDIENT
A composition for promoting mitochondrial biogenesis includes an effective amount of an azelaic acid or a pharmaceutically acceptable salt thereof as an active ingredient. Azelaic acid, which is a compound mainly contained in cereals and natural products has the advantage of no or little side effects, and induces mitochondrial autophagy and mitochondrial DNA synthesis in cells, thereby having activity of increasing mitochondrial density. Therefore, azelaic acid can be used for the treatment of mitochondrial dysfunction-associated disease caused by the failure of homeostasis control of the mitochondria, for example, mitochondrial activity or the decrease in the number of mitochondria. In addition, azelaic acid can be provided to reinforce a muscle function and prevent muscle aging using the activity, and to be effectively used in a food material, a pharmaceutical composition, and health functional foods for treating mitochondrial dysfunction-associated disease, reinforcing a muscle function, or preventing muscle aging.
Owner:KOREA UNIV RES & BUSINESS FOUND
Edible compound recipe mitochondrial energy enhancing formula
InactiveCN111374310APromote generationImprove metabolic efficiencyFood ingredient functionsPyrrovinyquiniumQuinoline
The invention belongs to the technical field of human health, and particularly discloses an edible compound recipe mitochondrial energy enhancing formula.The edible compound recipe mitochondrial energy enhancing formula comprises the components of pyrroloquinoline quinone, coenzyme Q10, nicotinamide mononucleotide, mecobalamin, calcium L-5-Methyltetrahydrofolate and complex vitamins B. The ediblecompound recipe mitochondrial energy enhancing formula is prepared through the steps of mixing the pyrroloquinoline quinone with the coenzyme Q10, the nicotinamide mononucleotide, the mecobalamin, thecalcium L-5-Methyltetrahydrofolate and the complex vitamins B to obtain finished products of the enhancing formula, and adding synergistic reaction components for NAD on-line plastochondria respiratory chain complexes and components for strengthening mitochondrial biogenesis, so that the respiratory chain metabolism efficiency is comprehensively improved, and the problem that a NAD precursor is separately supplemented, and the effect of improving vigour is not achieved, is solved. The components for assisting in NAM metabolism and discharge are added, so that the organism metabolism NAM pressure is reduced, and the potential risk that the NAD precursor is taken for a long time can be reduced.
Owner:上海益跬尔生物科技有限公司
5HT1F receptor agonists and mitochondrial biogenesis
Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, promote mitochondrial biogenesis and are useful for the treatment of, for example, acute kidney injury and chronic kidney disease.
Owner:U S GOVERNMENT REPRESENTED BY THE DEPT OF VETERANS AFFAIRS +1
Triple combination therapies for Anti-aging
InactiveCN113453690AReduce and/or eliminate age-related side effectsAccelerated agingCosmetic preparationsHair cosmeticsMitochondrial ribosomeAntibiotic resistance
The present approach effectively eradicates senescent cells and cells carrying the hallmarks associated with aging, through inhibiting mitochondrial biogenesis during induced mitochondrial oxidative stress, without inhibiting normal cells. Embodiments may include a therapeutic agent that inhibits mitochondrial biogenesis and targets the large mitochondrial ribosome, a therapeutic agent that inhibits mitochondrial biogenesis and targets the small mitochondrial ribosome, and a therapeutic agent that behaves as a pro-oxidant or induces mitochondrial oxidative stress. Some embodiments include sub-antimicrobial antibiotic concentrations, thereby minimizing antibiotic resistance concerns.
Owner:LUNELLA BIOTECH INC
Compositions comprising amino acids for use in the treatment of mitochondrial dysfunction-related diseases
ActiveUS20200253906A1Improve mitochondrial functionMetabolism disorderHeterocyclic compound active ingredientsDiseaseActive agent
Composition for promoting mitochondrial biogenesis and improving mitochondrial function in a subject, the composition comprising an active agent, said active agent containing the amino acids leucine, isoleucine, valine, threonine, lysine and citric acid, succinic acid, malic acid.
Owner:PROFESSIONAL DIETETICS SPA
Compositions comprising amino acids for use in the treatment of mitochondrial dysfunction-related diseases
Owner:PROFESSIONAL DIETETICS INT SRL
Compositions comprising amino acids for use in treatment of mitochondrial dysfunction-related diseases
Owner:PROFESSIONAL DIETETICS INT SRL
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