Compositions and Methods of Use of -hydroxy--methylbutyrate (HMB) for Decreasing Fat Mass

Abstract

The present invention provides a composition comprising HMB. Methods of administering HMB to an animal are also described. HMB is administered to enhance or promote lipolysis, increase adipocyte fat oxidation, induce adipocyte and muscle mitochondrial biogenesis, increase energy expenditure, decrease total body weight and increase body fat loss.

Description

[0001]This application claims priority to U.S. Provisional Patent Application No. 62 / 169,334 filed Jun. 1, 2015 and herein incorporates the provisional application by reference.BACKGROUND OF THE INVENTION[0002]1. Field[0003]The present invention relates to a composition comprising β-hydroxy-β-methylbutyrate (HMB) and methods of using HMB to enhance lipolysis, increase body fat loss, reduce adipocyte size, increase adipocyte fatty acid metabolism, reduce total body weight, and lower adipocyte inflammation.[0004]2. Background[0005]The high prevalence of obesity is a major public health and economic burden driving an urgent need for effective nutritional management of obesity and obesity-associated co-morbidities. Recently, chronic inflammation has been recognized as a contributing factor in the pathogenesis of many metabolic diseases, originating, in part, from adipose tissue. Specifically, adipocyte hypertrophy drives an inflammatory gene profile associated with metabolic dysfunction...

AI Technical Summary

Benefits of technology

The present invention aims to provide a composition for use in reducing body weight and excessive fat accumulation. Additionally, it also aims to increase energy expenditure.

Problems solved by technology

However, the science behind weight loss products has thus far been primarily based solely upon caloric restriction, and not the maintenance of lean tissue versus fat tissue loss.

In addition to devastating impact on quality of life, obesity and associated co-morbidities increase average annual medical costs per person by $2,741 (2005 dollars) compared to costs for normal weight people, including 46% increased inpatient costs, 27% more outpatient costs, and 80% increased spending on prescription drugs.

Additionally, costs attributable to lost productivity for full time employees are estimated to be $42.8 billion annually.

Exercise results in weight loss that is primarily accounted for by fat mass losses, with minor or significant increases in muscle mass.

Thus a need exists for compositions and methods of use of these compositions to result in fat loss in animals.

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