Compositions and Methods of Use of -hydroxy--methylbutyrate (HMB) for Decreasing Fat Mass

a technology of hydroxymethylbutyrate and hydroxymethylbutyrate, which is applied in the direction of anhydride/acid/halide active ingredients, antineoplastic agents, metabolic disorders, etc., can solve the problems of weight loss, maintenance of lean tissue versus fat tissue loss, and cost attributable to productivity loss for full time employees is estimated at $42.8 billion annually, and achieves fat loss and weight reduction

Inactive Publication Date: 2016-12-01
METABOLIC TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0020]One object of the present invention is to provide a com

Problems solved by technology

However, the science behind weight loss products has thus far been primarily based solely upon caloric restriction, and not the maintenance of lean tissue versus fat tissue loss.
In addition to devastating impact on quality of life, obesity and associated co-morbidities increase average annual medical costs per person by $2,741 (2005 dollars) compared to costs for normal weight people, including 46% increased inpatient costs, 27% mo

Method used

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  • Compositions and Methods of Use of -hydroxy--methylbutyrate (HMB) for Decreasing Fat Mass
  • Compositions and Methods of Use of -hydroxy--methylbutyrate (HMB) for Decreasing Fat Mass
  • Compositions and Methods of Use of -hydroxy--methylbutyrate (HMB) for Decreasing Fat Mass

Examples

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experimental examples

[0059]The following examples will illustrate the invention in further detail. It will be readily understood that the composition of the present invention, as generally described and illustrated in the Examples herein, could be synthesized in a variety of formulations and dosage forms. Thus, the following more detailed description of the presently preferred embodiments of the methods, formulations and compositions of the present invention are not intended to limit the scope of the invention, as claimed, but it is merely representative of the presently preferred embodiments of the invention.

[0060]Lipolysis in 3T3-F442A Adipocytes

[0061]Methods. Murine 3T3-F442A preadipocytes were grown until confluence. After confluence, 3T3-F442A cells were allowed to differentiate into adipocytes and become filled with triglycerides. Lipolysis was assessed as glycerol release from 3T3-F442A adipocytes in well plates. Adipocyte monolayers were incubated with Krebs-Ringer buffer containing Hepes (KRH),...

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Abstract

The present invention provides a composition comprising HMB. Methods of administering HMB to an animal are also described. HMB is administered to enhance or promote lipolysis, increase adipocyte fat oxidation, induce adipocyte and muscle mitochondrial biogenesis, increase energy expenditure, decrease total body weight and increase body fat loss.

Description

[0001]This application claims priority to U.S. Provisional Patent Application No. 62 / 169,334 filed Jun. 1, 2015 and herein incorporates the provisional application by reference.BACKGROUND OF THE INVENTION[0002]1. Field[0003]The present invention relates to a composition comprising β-hydroxy-β-methylbutyrate (HMB) and methods of using HMB to enhance lipolysis, increase body fat loss, reduce adipocyte size, increase adipocyte fatty acid metabolism, reduce total body weight, and lower adipocyte inflammation.[0004]2. Background[0005]The high prevalence of obesity is a major public health and economic burden driving an urgent need for effective nutritional management of obesity and obesity-associated co-morbidities. Recently, chronic inflammation has been recognized as a contributing factor in the pathogenesis of many metabolic diseases, originating, in part, from adipose tissue. Specifically, adipocyte hypertrophy drives an inflammatory gene profile associated with metabolic dysfunction...

Claims

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Application Information

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IPC IPC(8): A61K31/19
CPCA61K31/19A61P29/00A61P3/04A61P35/00A61P3/06A61P9/00A61P3/10
Inventor RATHMACHER, JOHNABUMRAD, NAJIBAIER, SHAWN
Owner METABOLIC TECH
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