653 results about "Pinellia tuberifera" patented technology

A construction method for and a use of rhizoma pinellinae praeparata decoction piece, standard decoction and formula granule characteristic spectra. The construction method comprises the following steps: dissolving a test sample by using a solvent, and extracting to obtain a solution to tested; and measuring said solution by using high-performance liquid chromatography (HPLC) to obtain rhizoma pinellinae praeparata decoction piece, standard decoction and formula granule characteristic spectra, wherein chromatographic conditions of the HPLC are as follows: the chromatographic column is a C18 column; and gradient elution is performed by using acetonitrile as mobile phase A and a 0.1% phosphoric acid aqueous solution as mobile phase B. HPLC is used, gradient elution is performed by using acetonitrile and a 0.1% phosphoric acid aqueous solution as mobile phases, and 4-hydroxybenzoic acid is used as a reference object, so that rhizoma pinellinae praeparata decoction piece, standard decoction and formula granule HPLC characteristic spectra are established; the method has good repeatability and precision, is stable and reliable, and can control the quality of rhizoma pinellinae praeparata decoction pieces, a standard decoction and formula granules.

The invention belongs to the field of medicines, and particularly relates to a traditional Chinese medicine compound for treating chronic obstructive pulmonary disease in a stable phase and application thereof. The traditional Chinese medicine composition is prepared from herba epimedii, rhizoma curculiginis, radix astragali, radix salviae miltiorrhizae, lumbricus, rhizoma dioscoreae nipponicae, radix ophiopogonis, radix scutellariae, radix adenophorae, rhizoma zingiberis, cortex mori radicis, rhizoma pinelliae, rhizoma coptidis and semen ginkgo, can play the main effects of tonifying lung and kidney, reducing phlegm and removing blood stasis, and is applied to the stable phase of the chronic obstructive pulmonary disease; the traditional Chinese medicine composition has a good clinical application effect in treatment of chronic obstructive pulmonary diseases, especially lung-kidney qi deficiency syndrome and phlegm-blood stasis syndrome.

The invention provides a method for rapidly detecting the processing degree of rhizoma pinellinae praeparata, and the method comprises the steps: calculating a wrinkle intensity feature from a preprocessed image based on a gray-level co-occurrence matrix, and determining the type of the processing degree of rhizoma pinellinae praeparata by analyzing the wrinkle intensity change of texture distribution in an evolution process from disorder to order; the method comprises the following steps: acquiring surface texture reconstruction data of a plurality of rhizoma pinellinae praeparata samples at each time node under different processing conditions, and establishing a corresponding relationship between image features and processing degree categories; according to the rhizoma pinellinae praeparata processing degree evaluation result, the temperature condition is adjusted, rhizoma pinellinae praeparata image data are collected again, the adjusted wrinkle density feature is extracted, and the rhizoma pinellinae praeparata dynamic change trend is obtained; and by comparing the adjusted rhizoma pinellinae praeparata dynamic change trend with the initial rhizoma pinellinae praeparata dynamic change trend, the processing quality control consistency is judged, and rapid detection of the rhizoma pinellinae praeparata processing degree is completed.

The invention relates to an antidepressant pharmaceutical composition and application thereof, and particularly discloses a pharmaceutical composition for treating depression as well as a preparation method and application thereof. The active pharmaceutical ingredients of the pharmaceutical composition are prepared from the following traditional Chinese medicines in parts by weight: 500 to 600 parts of radix bupleuri, 500 to 600 parts of fructus aurantii immaturus, 500 to 600 parts of radix aucklandiae, 500 to 600 parts of pericarpium citri reticulatae, 500 to 600 parts of rhizoma pinelliae preparata, 750 to 900 parts of herba taraxaci, 500 to 600 parts of scorched fructus crataegi, 300 to 360 parts of scorched semen arecae, 500 to 600 parts of paederia scandens, 300 to 400 parts of radix codonopsis, 300 to 400 parts of rhizoma corydalis and 500 to 600 parts of fried medicated leaven. The pharmaceutical composition has a remarkable curative effect on depression, animal experiments show that the pharmaceutical composition can remarkably enhance the social coefficient (showing that the pharmaceutical composition can improve social fear of depression patients) and improve sweet water preference (showing that the pharmaceutical composition is beneficial to transformation of negative emotions such as interest deficiency of the depression patients), and the pharmaceutical composition is safe to take, free of adverse reaction and toxic and side effects and free of toxic and side effects. And the composition can take effect quickly, and can take effect generally within 1-2 weeks after medication.

The invention relates to the technical field of traditional Chinese medicine detection, in particular to a UPLC-Q / TOF-MS identification method for pinellia ternate and rhizoma typhonii flagelliformis. According to the method, on the basis of pinellia ternate, ginger processed pinellia, rhizoma typhonii flagelliformis and ginger processed rhizoma typhonii flagelliformis component information collected by ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry, characteristic substances are screened in combination with a multivariate statistics method, OPLS-DA analysis is carried out on pinellia ternate and rhizoma typhonii flagelliformis, differential compounds of the pinellia ternate and the rhizoma typhonii flagelliformis are found, and The method comprises the following steps: determining five key compounds for identifying pinellia ternate, rhizoma typhonii flagelliformis and processed products thereof by combining a plurality of analysis methods such as box plot analysis, thermogram analysis and correlation analysis, then determining the relative content of the five key compounds, and establishing a pinellia ternate and rhizoma typhonii flagelliformis identification model by utilizing OPLS-DA analysis. The detection of rhizoma typhonii flagelliformis doped in the rhizoma pinelliae and processed products thereof can be realized.

The invention relates to the technical field of quality detection of traditional Chinese medicine preparations, in particular to a quality detection method of rhizoma pinelliae, rhizoma atractylodis macrocephalae and rhizoma gastrodiae granules, and the rhizoma pinelliae, rhizoma atractylodis macrocephalae and rhizoma gastrodiae granules established by the invention are proved to be safe and effective through quality inspection. The rhizoma pinelliae, rhizoma atractylodis macrocephalae and rhizoma gastrodiae granules not only keep the effects of eliminating dampness, reducing phlegm, calming the liver and calming endogenous wind in an original prescription, but also overcome the defects that a decoction is temporarily decocted, time-consuming and energy-consuming, is easy to mildew and deteriorate after being placed for a long time and the like, are smaller in dosage and more convenient to take, carry, store and transport, and greatly reduce the labor intensity and shorten the labor time, so that the production cost of the rhizoma pinelliae, rhizoma atractylodis macrocephalae and rhizoma gastrodiae granules is reduced. And the burden of people is greatly relieved, the market vacancy is filled, the economic benefit is considerable, and obvious advantages are achieved.

The invention relates to bacillus subtilis Y32, and the preservation number of the bacillus subtilis Y32 is CGMCC (China General Microbiological Culture Collection Center) No.34819. The strain can produce xylanase with high temperature resistance and high stability, various hydrolases such as beta-mannase, protease and the like, exopolysaccharides and botrytis cinerea inhibition, and is resistant to acid, swine bile salt and 10% NaCl. The optimum temperature of xylanase produced by the strain is 55 DEG C, the optimum pH value is 6.0, under the conditions, the half-life period is 12.5 h, the relative enzyme activity is still kept above 80% after incubation for 3 h, and the xylanase has good thermal stability. The strain can also improve the yield of cucumbers and pinellia ternate, and can also improve the laying rate of 70-week-old hyline brown laying hens from 70.4% to 90.1%. The strain has a good application prospect in the fields of agriculture, food processing and cosmetic production.

The invention belongs to the field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition for treating liver depression and spleen deficiency syndrome metabolism-related fatty liver disease, which is prepared from the following raw materials in parts by weight: 8 to 10 parts of ginseng, 10 to 15 parts of radix bupleuri, 10 to 15 parts of radix curcumae, 6 to 9 parts of ginger processed pinellia, 6 to 10 parts of fructus amomi, 10 to 15 parts of rhizoma atractylodis, 10 to 15 parts of poria cocos, 10 to 15 parts of semen hoveniae, 10 to 15 parts of radix rehmanniae, 8 to 10 parts of rhizoma polygoni cuspidati and 6 to 9 parts of lignum dalbergiae odoriferae. The traditional Chinese medicine composition is used for treating the metabolism-related fatty liver diseases from the aspects of liver depression, spleen deficiency and phlegm-blood stasis, starts from the core pathological chain of liver depression, spleen deficiency, phlegm-dampness and blood stasis, has the functions of soothing the liver, tonifying the spleen, resolving dampness, reducing fat and promoting blood circulation to remove meridian obstruction, and is particularly suitable for patients with liver depression, spleen deficiency and metabolism-related fatty liver diseases. Clinical tests prove that the traditional Chinese medicine composition has a good treatment effect on patients with liver depression and spleen deficiency syndrome metabolism-related fatty liver diseases, the total effective rate reaches 94% or above, and the traditional Chinese medicine composition is mild in medicine property, good in safety, stable in curative effect, not prone to relapse and suitable for being taken for a long time.

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition, a preparation method thereof and application of the traditional Chinese medicine composition in preparation of medicines for preventing and treating stress insomnia. The composition provided by the invention is composed of vinegar-processed rhizoma cyperi, green tangerine peel, pinellia ternate, poria with hostwood, salvia miltiorrhiza, ginseng, rhizoma acori graminei, nacre mother of pearl, crude dragon bone and ginger, and the comprehensive advantages of the composition in treatment of stress insomnia are shown through a multi-target and multi-channel regulation mechanism in combination with significant regulation effects of GO function enrichment and KEGG signal channels. The multi-layer action mechanism provides a unique treatment potential for the formula, and particularly has an important clinical application prospect in the aspect of coping with complex stress response and nerve dysfunction.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating meniere disease membrane hydrolost and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw material medicines: rhizoma alismatis, rhizoma atractylodis macrocephalae, poria cocos, gastrodia elata, ginger processed pinellia, pericarpium citri reticulatae and fresh ginger. The traditional Chinese medicine composition disclosed by the invention is small in dosage and special in effect, and dialectical compatibility is performed according to the phlegm-dampness theory of traditional Chinese medicine, combined with the pathological basis of the meniere disease and based on the treatment rules of transforming fluid retention, inducing diuresis, tonifying spleen and calming liver, so that the aim of treating both symptoms and root causes is achieved. Animal experiments prove that the traditional Chinese medicine composition can obviously relieve the cochlear hydrops degree of a rat with membranous hydrolost.

The invention relates to a traditional Chinese medicine for treating children autism, which can effectively solve the medication problems of good curative effect and convenience for treating children autism. The preparation method comprises the following steps: disinfecting and sterilizing radix bupleuri, radix paeoniae alba, fructus aurantii, rhizoma nardostachyos, rhizoma atractylodis macrocephalae, poria cocos, codonopsis pilosula, cassia twig, rhizoma acori graminei, cistanche, rhizoma alismatis, peach kernel, safflower, scutellaria baicalensis, pinellia ternate, honey-fried licorice root, rock candy and maltose, soaking, boiling with strong fire, decocting with slow fire, filtering, heating to prepare a traditional Chinese medicine concentrated solution, adding rock candy and maltose, decocting into thick paste, pouring into a mold, shaping at room temperature to form granules, and packaging. The traditional Chinese medicine composition is rich in raw materials, easy to operate in preparation method and scientific and reasonable in compatibility according to the primary and secondary relationship of monarch, minister, assistant and guide, has the effects of soothing the liver, strengthening the spleen, tonifying the kidney, replenishing essence, inducing resuscitation and promoting intelligence, is effectively used for treating autism of children, and has huge economic and social benefits.

The invention belongs to the technical field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition for improving obesity and metabolic syndrome and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 15 to 28 parts of radix astragali seu hedysari, 8 to 20 parts of radix codonopsis, 20 to 35 parts of rhizoma dioscoreae, 8 to 24 parts of semen lablab album, 6 to 20 parts of rhizoma atractylodis macrocephalae stir-fried with bran, 20 to 35 parts of raw semen coicis, 3 to 10 parts of rhizoma pinelliae preparata, 6 to 15 parts of pericarpium citri reticulatae, 10 to 20 parts of poria cocos, 6 to 15 parts of rhizoma alismatis, 6 to 15 parts of raw liquorice root, 10 to 20 parts of semen hoveniae, 10 to 20 parts of lotus leaf and 8 to 15 parts of raw fructus crataegi. The composition has the effects of invigorating spleen, replenishing qi, resolving dampness and removing turbidity, can effectively control the weight gain of obese patients and improve the metabolic disorder condition of metabolic syndrome, is safe, effective and stable, has small side effects, and has very good research and development values.

The invention relates to ginger processed pinellia decoction piece processing equipment and a processing technology thereof, and relates to the technical field of traditional Chinese medicine decoction piece processing. Performing soaking; performing cooking; performing cutting; performing drying; screening is conducted, specifically, chippings are screened out, and then the slices are subjected to color sorting screening; and packaging into bags. According to the processing method, chippings in the slices are screened out, and then screening is conducted through color sorting, so that the adverse effect of the chippings on color sorting is reduced, the screening effect is reduced, the quality of processed pinellia ternate can be guaranteed, and the potential risk for a drug user is reduced.

The invention belongs to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for treating chronic atrophic gastritis and a preparation method and application thereof. According to the technical scheme, the traditional Chinese medicine composition is characterized by being prepared from, by weight, 10-50 parts of radix codonopsis, 5-20 parts of roasted rhizoma atractylodis macrocephalae, 5-10 parts of rhizoma pinellinae praeparata, 2-8 parts of rhizoma coptidis, 8-40 parts of poria cocos, 5-15 parts of radix salviae miltiorrhizae, 3-6 parts of rhizoma zingiberis, 5-15 parts of rhizoma cyperi, 1-20 parts of radix actinidiae chinensis and 1-5 parts of radix glycyrrhizae preparata. The traditional Chinese medicine composition provided by the invention can improve the pathological morphology of stomach tissues, increase the expression of PG I and the ratio of PG I to PG II, reduce the level of inflammatory factors and improve the atrophy degree of gastric mucosa, and is used for treating stomachache, distention and fullness, anorexia, gastric noisy and other symptoms caused by spleen and stomach qi deficiency, qi stagnation and blood stasis and damp-toxin interjunction of patients with chronic atrophic gastritis.

The invention discloses a treatment formula acting on dizziness and a preparation method thereof, the treatment formula comprises the following raw materials: 50-70 parts of Poria cocos, 60-80 parts of radix bupleuri, 40-50 parts of cassia twig, 10-20 parts of bighead atractylodes rhizome, 20-30 parts of gastrodia elata, 12-21 parts of dried orange peel, 12-25 parts of white peony root, 5-12 parts of licorice, 4-12 parts of dragon bone, 3-8 parts of red sage root, and 3-8 parts of pinellia ternate, and the invention relates to the technical field of medicine preparation. According to the treatment formula acting on dizziness and the preparation method thereof, the dizziness symptom can be relieved, for example, the dizziness symptom is relieved, the balance capacity is improved, the dizziness attack frequency and duration are reduced, cerebral ischemia and cerebral blood supply insufficiency are improved, neural function recovery is facilitated, the memory is enhanced, meanwhile, through cooperation of the medicinal materials, the physique of a patient can be improved, and the curative effect is good. The headache and dizziness symptoms are fundamentally treated, and the effect is good.

The invention discloses a traditional Chinese medicine composition for treating gastroesophageal reflux and chronic gastritis, relates to the technical field of traditional Chinese medicines, and particularly aims to solve the problem of relatively narrow application prospects of treatment means applied to GERD at present in the background technology. Comprising rhizoma bletillae, calcined concha arcae, rhizoma pinelliae preparata, caulis bambusae in taeniam, fructus aurantii immaturus, pericarpium citri reticulatae, liquorice, poria cocos, coptis chinensis, fructus evodiae, platycodon grandiflorum and radix curcumae, and the traditional Chinese medicine composition is superior to western medicines, effective in treatment of the gastroesophageal reflux disease, small in side effect and economical and practical.

The invention discloses a traditional Chinese medicine composition for preventing and treating metabolism-related fatty liver diseases or metabolic syndromes. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 5-50 parts of sweet wormwood, 3-30 parts of scutellaria baicalensis, 5-50 parts of dandelion, 4-60 parts of platycodon grandiflorum, 5-50 parts of fructus aurantii, 3-80 parts of rhizoma pinelliae preparata, 3-70 parts of fructus amomi, 10-80 parts of stir-fried Chinese yam, 5-80 parts of poria cocos and 3-100 parts of raw coix seeds. The traditional Chinese medicine composition for preventing and treating the metabolism-related fatty liver diseases or the metabolic syndromes is simple in formula, proper in compatibility and mild in medicine property, is used for preventing and treating the metabolism-related fatty liver diseases or the metabolic syndromes, is used for improving liver fatty degeneration and inflammation, blood uric acid, blood fat, blood sugar and blood pressure, assisting weight loss and the like, and is safe to use and remarkable in curative effect.

The invention discloses a Su semi-poria cocos-tangerine decoction for relieving high secretion of mucus in an acute exacerbation stage of chronic obstructive pulmonary disease as well as a preparation method and application of the Su semi-poria cocos-tangerine decoction, and relates to the technical field of traditional Chinese medicine compositions. The Su semi-poria cocos and orange soup is prepared from 8-10 g of fructus perillae, 8-10 g of rhizoma pinellinae praeparata, 8-10 g of ginger processed cortex magnoliae officinalis, 8-10 g of radix peucedani, 4-6 g of fried semen brassicae, 8-10 g of fried semen raphani, 8-10 g of fried rhizoma atractylodis macrocephalae, 12-15 g of poria cocos, 4-6 g of fried pericarpium citri reticulatae and 2-3 g of cortex cinnamomi. Clinical application of the Su semi-poria cocos and tangerine decoction prepared by the invention shows that compared with a control group which is only treated by conventional western medicine, the secretion amount of mucoprotein MUC5AC is greatly reduced, traditional Chinese medicine symptom integral, CAT score and mMRC score are greatly reduced, symptoms of a patient are obviously relieved, and no adverse reaction occurs. Therefore, the Su semi-poria cocos and orange soup can relieve high secretion of mucus with the syndrome of AECOPD turbid phlegm obstructing lung and improve clinical symptoms of patients, and is good in safety.

The invention discloses a traditional Chinese medicine composition for treating gastroesophageal reflux disease and a preparation method and application thereof.The traditional Chinese medicine composition is prepared from ginger processed pinellia, poria cocos, semen armeniacae amarae, thunberg fritillary bulb, radix paeoniae alba, pericarpium citri reticulatae, cuttlebone, cassia twig, moutan bark, concha arcae, honey-fried licorice root and the like. Clinical research results show that the qi-regulating and backflow-inhibiting decoction provided by the invention can remarkably improve clinical symptoms of patients with gastroesophageal reflux diseases, can remarkably improve psychological health feelings of the patients with gastroesophageal reflux diseases, and is high in treatment effective rate, low in recurrence rate and good in safety.

The invention discloses a traditional Chinese medicine composition for treating asthma as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine, the traditional Chinese medicine composition comprises the following medicinal raw materials in parts by mass: 5-15 parts of ephedra, 10-30 parts of humulus scandens, 5-20 parts of radix sophorae flavescentis, 5-20 parts of earthworm, 10-30 parts of semen lepidii, 5-20 parts of rhizoma pinellinae praeparata, 3-9 parts of asarum, 10-30 parts of wild buckwheat, 5-20 parts of blackberry lily, 5-25 parts of raw almond, 5-20 parts of mangnolia officinalis and 5-20 parts of schisandra chinensis. The invention further discloses a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine has the beneficial effects that the traditional Chinese medicine treats asthma from dampness, has the core of clearing heat and eliminating phlegm, freeing lung and relieving asthma, and consolidating foundation and clearing damp, can improve the damp syndrome state of asthma patients, relieve clinical symptoms such as wheeze, shortness of breath, chest distress and cough, improve the life quality and improve the asthma control level, and has potential advantages of reducing acute attack of asthma.

The invention relates to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for resisting stem cell aging as well as a preparation method and application thereof. The traditional Chinese medicine composition comprises 30 parts of astragalus membranaceus, 15 parts of fructus psoraleae, 15 parts of codonopsis pilosula, 15 parts of roasted rhizoma atractylodis macrocephalae, 10 parts of eucommia ulmoides, 15 parts of herba epimedii, 15 parts of glossy privet fruit, 15 parts of Chinese yam, 15 parts of radix paeoniae alba, 15 parts of gynostemma pentaphylla, 6 parts of pseudo-ginseng powder, 20 parts of sculellaria barbata, 15 parts of poria cocos, 10 parts of radix bupleuri, 30 parts of raw oyster shell, 15 parts of vinegar turtle shell, 15 parts of rhizoma pinellinae praeparata, 15 parts of eclipta, 6 parts of pericarpium citri reticulatae and 6 parts of liquorice. The preparation method comprises water extraction and concentration to prepare powder. The composition can be used for inhibiting the aging of the mesenchymal stem cells and improving the cell activity, and can be combined with the mesenchymal stem cells to treat degenerative bone diseases including osteoporosis and femoral head necrosis.

The invention discloses a Pinellia ternata NAC transcription factor PtNAC61 as well as a coding gene and application thereof, belongs to the technical field of genetic engineering, and provides the Pinellia ternata NAC transcription factor PtNAC61 which is any one of the following proteins: (1) a protein consisting of an amino acid residue sequence in SEQ ID NO.1; (2) a protein which is obtained by substituting and / or deleting and / or adding one to ten amino acid residues on the amino acid residue sequence in the SEQ ID NO.1, has a pinellia ternata NAC transcription factor function and is derived from (1); the invention also provides a PtNAC61 gene for coding the NAC transcription factor Pt NAC61 of the pinellia ternate. The PtNAC61 gene is separated and cloned from pinellia ternate, the PtNAC61 gene is introduced into the pinellia ternate through an agrobacterium tumefaciens-mediated transformation method, a transgenic plant is obtained, it is verified that the drought stress tolerance of the transgenic pinellia ternate is improved, the anti-aging capacity of leaves is improved, an important gene resource is provided for plant stress-resistant gene engineering, and the PtNAC61 gene has a wide application prospect. The important significance is realized on improving the yield of medicinal plants.

The invention provides a traditional Chinese medicine preparation for treating climacteric syndrome in breast cancer endocrine therapy, and belongs to the technical field of traditional Chinese medicine preparations. The traditional Chinese medicine preparation comprises 9-12 g of radix bupleuri, 9-15 g of scutellaria baicalensis, 9-15 g of rhizoma pinelliae preparata, 15-30 g of codonopsis pilosula, 9-15 g of cassia twig, 9-15 g of radix paeoniae alba, 9-15 g of calcined dragon bone, 9-15 g of calcined oyster shell, 15-30 g of rhizoma acori graminei, 9-15 g of radix curcumae, 9-15 g of roasted turtle shell, 9 g of ginger and 9 g of jujube. The traditional Chinese medicine preparation can effectively relieve symptoms such as chest and hypochondrium distension and stuffiness, depression, dysphoria and other emotion regulation, hypochondrium pain and the like of patients with breast cancer endocrine therapy climacteric syndromes.

The invention discloses a traditional Chinese medicine composition for preventing and treating premature ovarian failure and application thereof. Belongs to the technical field of traditional Chinese medicine. The traditional Chinese medicine composition comprises gordon euryale seed, agilawood, sandalwood, processed rhizoma pinelliae, rheum officinale, amomum cardamomum, alpinia katsumadai, processed rhizoma arisaematis, processed radix aconiti, asarum, fructus aurantii and fructus piperis longi. The composition follows the compatibility principle of monarch, minister, assistant and guide in traditional Chinese medicine, belongs to a composite traditional Chinese medicine preparation, and needs to regulate the reproductive endocrine function through the synergistic effect of multiple medicinal materials. The traditional Chinese medicine focuses on phlegm-dampness stasis and kidney-yang deficiency type infertility and premature ovarian failure. The prior art purely focuses on tonifying the kidney (such as prepared rehmannia root and dogwood) or activating blood (such as peach kernel and safflower), while the formula disclosed by the invention integrates multiple effects of resolving dampness, warming and dredging, removing stasis, promoting the circulation of qi and the like, and is stronger in pertinence.

The invention relates to a traditional Chinese medicine compound composition for inhibiting lung cancer metastasis and application thereof. The traditional Chinese medicine compound composition is prepared from the following raw material medicines in parts by weight: 40-45 parts of radix ophiopogonis, 4-8 parts of pinellia ternate, 4-8 parts of liquorice, 7-11 parts of ginseng, 4-8 parts of polished round-grained rice, 12-20 parts of Chinese dates and 18-27 parts of paris polyphylla. Compared with the prior art, the traditional Chinese medicine composition has a remarkable inhibiting effect on lung cancer metastasis, can remarkably induce lung cancer cell apoptosis and effectively inhibits proliferation and migration of lung cancer cells; animal experiments show that the traditional Chinese medicine composition not only can effectively reduce the number of mouse lung metastatic tumors, but also remarkably reduces the lung tumor metastasis load. In addition, the traditional Chinese medicine composition also remarkably increases the level of NK cells and CD8 + T cells in peripheral blood.

The invention belongs to the field of medical science, and relates to a traditional Chinese medicine, in particular to a traditional Chinese medicine composition for treating chronic coronary syndrome and fading coronary artery and carotid plaques as well as a preparation method and application of the traditional Chinese medicine composition. The formula of the composition comprises 10 to 30 g of radix astragali, 10 to 18 g of salvia chinensis, 20 to 40 g of euphorbia lunulata, 6 to 15 g of rhizoma pinelliae preparata, 6 to 15 g of ginseng, 6 to 15 g of cassia twig, 6 to 15 g of radix puerariae, 6 to 15 g of dried ginger, 5 to 15 g of rhizoma cimicifugae, 5 to 15 g of radix bupleuri, 6 to 20 g of bighead atractylodes rhizome, 5 to 15 g of pericarpium citri reticulatae, 6 to 15 g of radix scutellariae, 12 to 30 g of cynanchum glaucescens, 5 to 15 g of angelica sinensis, 5 to 15 g of radix curcumae, 10 to 30 g of salvia miltiorrhiza, and 6 to 15 g of honey-fried licorice root. The composition provided by the invention treats the origin of the aggregation by tonifying qi, eliminating the aggregation, activating yang and removing stasis, and treats the source of the aggregation by tonifying spleen, reducing phlegm, promoting blood circulation to remove blood stasis and smoothing the vein, not only has an exact curative effect on improving the clinical symptoms of the chronic coronary syndrome, but also can prevent the progression of arteriosclerosis and subside coronary artery and carotid plaques, and not only has obvious curative effect on the clinical symptoms, but also has obvious curative effect on the coronary artery and carotid artery plaques. The basic pathological change of atherosclerosis can be improved, so that the chronic coronary syndrome is treated, the pathological progress of the chronic coronary syndrome is prevented and treated, the curative effect is remarkable, and the safety problem is few.

A patchouli Qi-rectifying tablet, and a preparation method therefor and a qualitative and quantitative determination method therefor. The patchouli Qi-rectifying tablet comprises the following components in parts by mass: 0.5-1.5 parts of patchouli oil; 0.1-1 part of perilla leaf oil; 150-250 parts of common aucklandia root; 100-150 parts of rhizome of swordlike atractylodes; 10-100 parts of root of Ural licorice; 150-250 parts of Indian bread; 100-150 parts of dried tangerine peel; 100-150 parts of prepared tuber of pinellia; 100-150 parts of officinal magnolia bark; and 100-150 parts of fresh ginger. The qualitative and quantitative determination method for multiple components in the patchouli Qi-rectifying tablet comprises: performing qualitative determination of ten components, i.e., liquiritin, hesperidin, honokiol, costunolide, dehydrocostus lactone, magnolol, atractylodin, perilla ketone, nobiletin, and tangeretin, in the patchouli Qi-rectifying tablet; and performing quantitative determination of seven components, i.e., liquiritin, hesperidin, honokiol, costunolide, dehydrocostus lactone, magnolol, and atractylodin, in the patchouli Qi-rectifying tablet. According to the method, the operation is simple, the detection time is short, the linear relationship is good, the repeatability is good, the precision is high, the accuracy is high, and the stability is good.

The invention discloses an esophageal cancer targeting nano-tablet based on a traditional Chinese medicine composition and a preparation method of the esophageal cancer targeting nano-tablet. The targeted nano tablet is prepared from the following refined extracts: a rhizoma paridis total saponin extract, a pseudobulbus cremastrae seu pleiones colchicine derivative extract, a panax notoginseng total saponin extract, a carthamin yellow extract, a thunberg fritillary bulb total alkaloid extract, frankincense-myrrh compound volatile oil, a resin extract and an astragaloside IV extract. The nano-carrier comprises a nano-carrier, a seaweed-laminarin composite extract, a processed rhizoma pinelliae total alkaloid extract and costus root volatile oil, and the costus root volatile oil serves as one of targeting ligands to be used for modifying the nano-carrier. The targeting property is strong: the dual-targeting ligand (costunolide-TOPK affinity peptide) on the surface of the nano-carrier can actively recognize and combine with a specific receptor of esophageal cancer cells, and meanwhile, due to the size (about 100-200 nanometers) of the carrier, the carrier is easy to enrich in tumor tissues through enhanced permeation and retention (EPR) effect, so that the modernization upgrading of the idea of'channel guiding medicine 'is realized.

The invention discloses a pharmaceutical composition and application, and belongs to the technical field of traditional Chinese medicines. The invention discloses a pharmaceutical composition for treating dizziness. The pharmaceutical composition comprises the following raw materials: rhizoma pinellinae praeparata, rhizoma atractylodis macrocephalae fried with bran, gastrodia elata, uncaria, rhizoma cimicifugae, radix bupleuri, platycodon grandiflorum, ligusticum wallichii and radix cyathulae. The pharmaceutical composition takes rhizoma atractylodis macrocephalae stir-fried with bran as a monarch drug and has the effects of invigorating spleen and replenishing qi; rhizoma gastrodiae has the effects of calming liver wind and activating meridians to stop pain, and rhizoma pinellinae praeparata and rhizoma gastrodiae serve as ministerial drugs; the rhizoma chuanxiong has the effects of pungent temperature rising, qi promoting, blood activating, peripheral blood vessel expanding and microcirculation disturbance improving, the radix cyathulae has the effects of promoting blood circulation, removing blood stasis and descending sexual capacity, and the rhizoma chuanxiong and the radix cyathulae are mutually used and are increased and decreased, so that qi and blood circulatory flow is realized, and no blood stasis is caused; uncaria can clear heat, calm liver and clear head and eyes; in addition, a small amount of cimicifugae foetidae and radix bupleuri are used for lifting the clear yang to clear the head and eyes, and the five medicines are used as adjuvant drugs. The platycodon grandiflorum is used as the medicine and leads the medicine to move upwards to directly reach the head surface; the traditional Chinese medicine is used as a conductant drug. All the medicines are combined to lift clear yang, circulatory flow of qi and blood, both symptoms and root causes are taken into consideration, wind-phlegm is treated, and qi and blood are regulated together.

The traditional Chinese medicine composition is prepared from the following components in parts by mass: 6 to 12 parts of rhizoma gastrodiae, 9 to 15 parts of fried semen ziziphi spinosae, 6 to 12 parts of radix achyranthis bidentatae, 10 to 20 parts of nacre mother of pearl, 10 to 20 parts of poria with hostwood, 5 to 11 parts of fried radix paeoniae alba, 3 to 9 parts of bupleurum chinense, 3 to 9 parts of fried fructus aurantii, 2 to 8 parts of honey-fried licorice root, 2 to 8 parts of radix scutellariae and 2 to 8 parts of rhizoma pinelliae. Compared with an Androp prescription, the Androp granules have more remarkable effects in the aspects of reduction of systolic pressure, diastolic pressure and the like of a subject.