Compositions comprising amino acids for use in treatment of mitochondrial dysfunction-related diseases

Abstract

Composition for promoting mitochondrial biogenesis and improving mitochondrial function in a subject, the composition comprising an active agent, said active agent containing the amino acids leucine,isoleucine, valine, threonine, lysine, citric acid, succinic acid, and malic acid.

Description

technical field

[0001] The present description generally relates to compositions comprising amino acids. More specifically, the description relates to compositions comprising amino acids for use in medicine, in particular for the treatment of diseases associated with mitochondrial dysfunction. Background technique

[0002] Mitochondria are organelles whose main function is oxidative phosphorylation, the process by which they convert energy derived from glucose or fatty acid metabolism into adenosine triphosphate (ATP). ATP is then used to drive a variety of energy-demanding biosynthetic reactions and other metabolic activities.

[0003] Mitochondrial dysfunction can affect any tissue, resulting in a wide variety of symptoms, depending on the extent to which different tissues are involved.

[0004] Diseases caused by mitochondrial dysfunction may include, for example: mitochondrial swelling due to underlying malfunction of the mitochondrial membrane, oxidative stress (e.g. ...

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