Compositions comprising amino acids for use in treatment of mitochondrial dysfunction-related diseases

一种功能障碍、组合物的技术，应用在包含氨基酸的组合物领域，能够解决尚未发现药物或营养物等问题

Pending Publication Date: 2020-04-10
PROFESSIONAL DIETETICS INT SRL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

No drugs or nutrients have been found to prevent and / or treat this condition

Method used

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  • Compositions comprising amino acids for use in treatment of mitochondrial dysfunction-related diseases
  • Compositions comprising amino acids for use in treatment of mitochondrial dysfunction-related diseases
  • Compositions comprising amino acids for use in treatment of mitochondrial dysfunction-related diseases

Examples

Experimental program
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Effect test

Embodiment

[0065] Table 1 shows the different amino acid-based compositions tested on HL-1 cells and on immortalized brown adipocytes, as disclosed below.

[0066] In particular, the BCAAem composition is the composition disclosed in EP 2 196 203 B1.

[0067] The composition designated "B2" has a similar combination of amino acids as the BCAAem composition as the active agent, but B2 also contains citric acid. Such compositions also contain vitamins B1 and B6.

[0068] Compositions designated alpha 5 (α5), alpha 6 (α6), alpha 7 (α7) comprise active agents comprising amino acids and citric, succinic and malic acids. In addition, the active agents of the alpha 7 composition also include OKG (ornithine L-alpha ketoglutarate) and the amino acid aspartic acid (L-aspartic acid).

[0069] Table 1

[0070]

[0071]

[0072]The compositions of Table 1 above can be prepared by first screening all components with 0.8 mesh. To obtain a premix, each ingredient (in amounts <10% by weight of ...

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PUM

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Abstract

Composition for promoting mitochondrial biogenesis and improving mitochondrial function in a subject, the composition comprising an active agent, said active agent containing the amino acids leucine,isoleucine, valine, threonine, lysine, citric acid, succinic acid, and malic acid.

Description

technical field [0001] The present description generally relates to compositions comprising amino acids. More specifically, the description relates to compositions comprising amino acids for use in medicine, in particular for the treatment of diseases associated with mitochondrial dysfunction. Background technique [0002] Mitochondria are organelles whose main function is oxidative phosphorylation, the process by which they convert energy derived from glucose or fatty acid metabolism into adenosine triphosphate (ATP). ATP is then used to drive a variety of energy-demanding biosynthetic reactions and other metabolic activities. [0003] Mitochondrial dysfunction can affect any tissue, resulting in a wide variety of symptoms, depending on the extent to which different tissues are involved. [0004] Diseases caused by mitochondrial dysfunction may include, for example: mitochondrial swelling due to underlying malfunction of the mitochondrial membrane, oxidative stress (e.g. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/194A61K31/198A61P3/04
CPCA61K31/194A61K31/198A61K31/4415A61K31/51A61P3/04A61K2300/00A61K31/405A61K31/4172
Inventor 保罗·卢卡·马里亚·焦尔杰蒂
Owner PROFESSIONAL DIETETICS INT SRL
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