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Hydroxytyrosol combinations for enhancing mitochondrial function and energy production

a technology of mitochondrial function and hydroxytyrosol, which is applied in the direction of biocide, drug composition, metabolic disorder, etc., can solve the problems of cellular ph, potential contractile fatigue, temporary dead end, etc., and achieve the effect of increasing the expression of mtdna, significant increase of the ratio of int d-loop/18srna, and significant increase of the basal rate of oxygen consumption

Inactive Publication Date: 2012-09-06
DSM IP ASSETS BV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0009]It has been found, in accordance with this invention, that hydroxytyrosol (“HT”) in combination with at least one of the compounds selected from the group consisting of: creatine, coenzyme Q10, resveratrol, caffeine, carnitine, B vitamins (B1 or thiamine; B2 or riboflavin; B3 or niacin or niacinamide; B5 or pantothenic acid; B6 or pyridoxine, pyridoxal, pyridoxamine, or pyridoxine hydrochloride; B7 or biotin; B9 or folic acid; or B12 or various cobalamins, such as cyanocobalamin), quercetin, alpha-lipoic acid, EGCG and ginseng extract synergistically enhances the body's own energy metabolism by inducing mitochondrial biogenesis and can lead to an increased mitochondrial function in tissues.

Problems solved by technology

Conversion to lactate means a temporary dead end in the energy yielding process, and the potential for contractile fatigue due to decreasing cellular pH if lactic acid accumulation proceeds unchecked.
This unstable intermediate can lead to electron “leakage”, when electrons jump directly to oxygen and form the superoxide anion, instead of moving through the normal series of well-controlled reactions of the electron transport chain.
While it has been generally accepted in the past that administration of antioxidants would be beneficial to promote mitochondrial biogenesis, this has not been shown to be the case.

Method used

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  • Hydroxytyrosol combinations for enhancing mitochondrial function and energy production
  • Hydroxytyrosol combinations for enhancing mitochondrial function and energy production
  • Hydroxytyrosol combinations for enhancing mitochondrial function and energy production

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0133]Anti-rabbit PGC-1α and anti-rabbit PPAR-γ were purchased from Santa Cruz (Calif., USA); anti-α-tubulin from Sigma (St. Louis, Mo., USA); Mito-Tracker Green FM, anti-oxidative complex I, II, III, and V from Invitrogen (Carlsbad, USA); SYBR® GREEN PCR Master Mix from ABI (Warrington, UK); BD Oxygen Biosensor System plate from BD Biosciences (California, USA); Hydroxytyrosol (DSM Nutritional Products); Mitochondrial D-loop and 18SRNA primers were synthesized by Bioasia Biotech (Shanghai, China), other reagents for cell culture were from Invitrogen (Carlsbad, USA).

Cell Culture and Adipocyte Differentiation

[0134]Murine 3T3-L1 pre-adipocytes (American Type Culture Collection) were cultured in Dulbecco's Modified Eagle's Medium (DMEM) supplemented with 10% fetal bovine serum and allowed to reach confluence. Differentiation of pre-adipocytes was initiated with 1 μM insulin, 0.25 μM dexamethasone and 0.5 mM 3-isobutyl-1-methylxanthine in DMEM, supplemented with 10% fetal bovine serum. ...

example 2

Effect of Hydroxytyrosol on Endurance

[0151]The purpose of the study was to determine the effect of hydroxytyrosol on maximal running performance on a treadmill.

[0152]In short, forty mice (C57BL / 6NCrl; 8 wks old) were purchased from Charles River (Sulzfeld, Germany) and housed individually with free access to water and feed, with an alternating 12-hour light-dark cycle. The animals were fed a standard rodent diet (Ssniff R / M-H, Ext. no. V1536, Ssniff Ltd., Soest, Germany). After 2 weeks of adaptation to the diet the mice were randomized according to body weight into four experimental groups of 10 animals. The four groups were treated orally every morning for 3 weeks with either water (control group) or with an olive extract diluted to 0.2 ml with water and containing 50% hydroxytyrosol at doses of 50, 150, or 300 mg / kg body weight per day. There was no difference in feed consumption over the whole experiment. After 3 weeks of treatment the maximal running distance on a treadmill was ...

example 3

[0154]An energy drink contains 50 mg hydroxytyrosol and 100 mg caffeine / serving.

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Abstract

Hydroxytyrosol or olive juice containing hydroxytyrosol in combination with at least one of the compounds selected from the group consisting of: creatine, coenzyme Q10, resveratrol, caffeine, carnitine, B vitamins (B1, B2, B3, B5, B6, and / or B12) and ginseng (preferably: root) extract can be used to maintain or increase mitochondrial biogenesis in cardiac muscle, skeletal muscles, and liver tissue.

Description

FIELD OF THE INVENTION[0001]This invention is related to the use of hydroxytyrosol (“HT”), or a composition containing hydroxytyrosol or a precursor of hydroxytyrosol in combination with at least one of the compounds selected from the group consisting of: creatine, coenzyme Q10, resveratrol, caffeine, carnitine, B vitamins (B1 or thiamine; B2 or riboflavin; B3 or niacin or niacinamide; B5 or pantothenic acid; B6 or pyridoxine, pyridoxal, pyridoxamine, or pyridoxine hydrochloride; B7 or biotin; B9 or folic acid; or B12 or various cobalamins, such as cyanocobalamin), quercetin, alpha-lipoic acid, epigallocatechin (EGCG) and ginseng extract. These compositions synergistically enhance the body's own capacity for energy generation and / or enhance cellular energy generation. It also relates to pharmaceutical and nutraceutical compositions useful for conditions characterized by altered mitochondrial functioning and biogenesis, such as heart strength, various liver diseases, improve muscle / f...

Claims

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Application Information

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IPC IPC(8): A61K31/714A61P3/02A61K31/522A61P21/00A61K31/045A61K31/352A23L33/00
CPCA23K1/1603A61K31/4406A23K1/1618A23K1/1631A23L1/296A23L1/30A23L1/3002A23L1/302A23L1/3051A23L2/52A23V2002/00A61K31/05A61K31/122A61K31/197A61K31/205A61K31/4188A61K31/4415A61K31/455A61K31/51A61K31/522A61K31/525A61K31/714A61K36/63A61K45/06A23K1/1612A61K31/352A23L1/3004A61K31/145A61K31/19A61K31/195A61K31/34A61K2300/00A23V2200/33A23V2250/2108A23V2250/7042A23V2250/7044A23V2250/7046A23V2250/705A23V2250/706A23V2250/72A23K20/174A23K20/111A23K20/121A23K20/147A23L33/40A23L33/10A23L33/105A23L33/11A23L33/15A23L33/175A61P1/16A61P21/00A61P3/02A61P3/04A61P43/00
Inventor FOWLER, ANNFRIEDEL, ANGELIKAKNUTTI, DARKOKURATLI, KARINRAEDERSTORFF, DANIELWANG-SCHMIDT, YINGWERTZ, KARIN
Owner DSM IP ASSETS BV
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