The invention provides a pharmaceutical composition for mild
photothermal therapy of tumors as well as a preparation method and application of the pharmaceutical composition. The pharmaceutical composition is composed of a dual-targeting amphiphilic
glucan derivative carrier, a material (PTA) with photo-thermal conversion performance and an
autophagy inhibitor. The dual-targeting amphiphilic
glucan derivative carrier can be self-assembled in water to form nano-micelles, and is physically loaded with PTA and an
autophagy inhibitor for tumor
photothermal therapy. The preparation is mainly characterized in that: 1) the preparation has active dual-targeting capability of
tumor cells and tumor-related fibroblasts, and can efficiently enter the cells through the action of
receptor ligands, so that the
transfer efficiency of the preparation is improved; 2) under the
irradiation of 808nm
laser, PTA absorbs
light energy and efficiently converts the
light energy into heat, and the
autophagy inhibitor inhibits the autophagy behavior of
tumor cells and sensibilizes photo-thermal, so that an excellent mild photo-
thermal treatment effect is realized, and the
physical barrier of a tumor matrix can be weakened; tumor photothermal can further induce
tumor cells to generate
immunogenic cell death, generated tumor fragments can further activate an
immune system, and the tumor photothermal
treatment effect is greatly improved.