Compositions comprising amino acids for use in the treatment of mitochondrial dysfunction-related diseases

A dysfunctional, mitochondrial technology, applied in the direction of drug combination, muscular system disease, nervous system disease, etc., can solve the problem of widespread adoption by the less elderly

Pending Publication Date: 2020-04-10
PROFESSIONAL DIETETICS INT SRL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0011] Despite the beneficial effects of CR in humans, such dietary regimens are unlikely to be widely adopted in older adults

Method used

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  • Compositions comprising amino acids for use in the treatment of mitochondrial dysfunction-related diseases
  • Compositions comprising amino acids for use in the treatment of mitochondrial dysfunction-related diseases
  • Compositions comprising amino acids for use in the treatment of mitochondrial dysfunction-related diseases

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Experimental program
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Embodiment

[0064] As disclosed below, Table 1 shows the different amino acid-based compositions tested on HL-1 cells.

[0065] In particular, the BCAAem composition is the composition disclosed in EP 2 196 203 B1.

[0066] The composition designated "B2" has a similar combination of amino acids as the BCAAem composition as the active agent, but B2 also contains citric acid. Such compositions also contain vitamins B1 and B6.

[0067] Compositions designated alpha 5 (α5), alpha 6 (α6), alpha 7 (α7) comprise active agents comprising amino acids and citric, succinic and malic acids. In addition, the active agents of the alpha 7 composition also include OKG (ornithine L-alpha ketoglutarate) and the amino acid aspartic acid (L-aspartic acid).

[0068] Table 1

[0069]

[0070] The compositions of Table 1 above can be prepared by first screening all components with 0.8 mesh. To obtain a premix, each ingredient (in amounts <10% by weight of the total) was placed in a polyethylene bag toge...

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Abstract

Composition for promoting mitochondrial biogenesis and improving mitochondrial function in a subject, the composition comprising an active agent, said active agent containing the amino acids leucine,isoleucine, valine, threonine, lysine and citric acid, succinic acid, malic acid.

Description

technical field [0001] The present description generally relates to compositions comprising amino acids. More specifically, the description relates to compositions comprising amino acids for use in medicine, in particular for the treatment of diseases associated with mitochondrial dysfunction. Background technique [0002] Mitochondria are organelles whose main function is oxidative phosphorylation, the process by which they convert energy derived from glucose or fatty acid metabolism into adenosine triphosphate (ATP). ATP is then used to drive a variety of energy-demanding biosynthetic reactions and other metabolic activities. [0003] Mitochondrial dysfunction can affect any tissue, resulting in a wide variety of symptoms, depending on the extent to which different tissues are involved. [0004] Diseases caused by mitochondrial dysfunction may include, for example: mitochondrial swelling due to underlying malfunction of the mitochondrial membrane, oxidative stress (e.g. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/194A61K31/198A61P21/00A61P9/04
CPCA61K31/198A61P25/28A61P25/16A61P25/14A61P25/00A61K31/194A61K2300/00A61K45/06A61P43/00A61K31/405A61K31/51A61K31/675
Inventor 保罗·卢卡·马里亚·焦尔杰蒂
Owner PROFESSIONAL DIETETICS INT SRL
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