Compound allopurinol dispersible tablet

Abstract

The invention relates to the field of medicines, in particular to a compound allopurinol dispersible tablet. The tablet is prepared by the following steps of: respectively sieving 100g of allopurinol, 20g of benzbromarone, 22g of sodium starch glycolate and 4g of superfine silica gel powder by a sieve of 80 meshes; putting 104g of microcrystalline cellulose in an oven at the temperature of 80 DEG C, baking for 2 hours, and sieving by the sieve of 80 meshes for later use; taking the prescription amounts of allopurinol and benzbromarone, and uniformly mixing by an equivalent amount increasing method; taking the prescription amounts of sodium starch glycolate and microcrystalline cellulose and half of the prescription amount of superfine silica gel powder, adding into the mixture of allopurinol and benzbromarone by the equivalent amount increasing method, and uniformly mixing; taking the mixture, using water as an adhesive to make damp mass, sieving by a sieve of 24 meshes to granulate, drying for 3 hours at the temperature of 60-70 DEG C, and arranging particles by a sieve of 22 meshes; uniformly mixing the left half of the prescription amount of superfine silica gel powder with the particles and tabletting, and the weight of each tablet is 0.25g.

Description

technical field [0001] The invention relates to the field of medicines, and is a novel medicine for treating gout and secondary hyperuricemia. Background technique [0002] At present, the clinical treatment of gout is mainly based on colchicine, non-steroidal anti-inflammatory drugs, hormones, promoting uric acid excretion and inhibiting uric acid synthesis. For patients with acute attacks, colchicine and anti-inflammatory analgesics are generally used, such as: phenylbutazone or hydroxyphenylbutazone, indomethacin, ibuprofen, pylorixicam, naproxen, etc.; use in intermittent and chronic periods Drugs that promote uric acid excretion. Due to the lack of specific chemicals for the treatment of gout, domestic companies have not developed some important varieties for the treatment of gout. These drugs generally have anti-inflammatory and analgesic effects, such as: Tongfengding Capsules, Zhitong Fengshi Pills, Tongfengshu Capsules, Binhuo Tongfeng Mixture , Tongfengding Table...

AI Technical Summary

Problems solved by technology

Due to the lack of specific chemicals for the treatment of gout, domestic companies have not developed some important varieties for the treatment of gout. These drugs generally have anti-inflammatory and analgesic effects, such as: Tongfengding Capsules, Zhitong Fengshi Pills, Tongfengshu Capsules, Binhuo Tongfeng Mixture , Tongfengding Tablets, sometimes some drugs used to treat rheumatoid arthritis are also used for gout