Compound allopurinol dispersible tablet

A compound allopurinol, dispersible tablet technology, applied in the directions of pharmaceutical formulations, organic active ingredients, medical preparations containing active ingredients, etc., can solve problems such as lack, improve production efficiency, reduce the influence of heat sensitivity, and shorten the process flow Effect

Inactive Publication Date: 2010-07-07
HUBEI GUANGREN PHARMACEUTICAL CO LTD
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the lack of specific chemicals for the treatment of gout, domestic companies have not developed some important varieties for the treatment of gout. These drugs generally have anti-inflammatory and analgesic effects, such as: Tongfengding Capsules, Zhitong Fengshi Pills, Tongfengshu Capsules, Binhuo Tongfeng Mixture , Tongfengding Tablets, sometimes some drugs used to treat rheumatoid arthritis are also used for gout

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0006] The present invention will be further described below in combination with practical examples.

[0007] Take 100g of allopurinol, 20g of benzbromarone, 22g of sodium carboxymethyl starch, and 4g of micropowder silica gel and pass through a 80-mesh sieve respectively; put 104g of microcrystalline cellulose in an oven at 80°C, bake for 2 hours, pass through an 80-mesh sieve, and set aside; Take the prescribed amount of allopurinol and benzbromarone, and mix them uniformly according to the method of equal increments; separately take the prescribed amount of microcrystalline cellulose, sodium carboxymethyl starch and one-half of the prescribed amount of micropowder silica gel, and still press the equal amount Add it to the mixture of allopurinol and benzbromarone by increasing the amount, and mix evenly; take the above drug mixture, use water as the binder, make a soft material, pass through a 24-mesh sieve to granulate, and dry at 65±5°C for 3 Hours later, granulate with a ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to the field of medicines, in particular to a compound allopurinol dispersible tablet. The tablet is prepared by the following steps of: respectively sieving 100g of allopurinol, 20g of benzbromarone, 22g of sodium starch glycolate and 4g of superfine silica gel powder by a sieve of 80 meshes; putting 104g of microcrystalline cellulose in an oven at the temperature of 80 DEG C, baking for 2 hours, and sieving by the sieve of 80 meshes for later use; taking the prescription amounts of allopurinol and benzbromarone, and uniformly mixing by an equivalent amount increasing method; taking the prescription amounts of sodium starch glycolate and microcrystalline cellulose and half of the prescription amount of superfine silica gel powder, adding into the mixture of allopurinol and benzbromarone by the equivalent amount increasing method, and uniformly mixing; taking the mixture, using water as an adhesive to make damp mass, sieving by a sieve of 24 meshes to granulate, drying for 3 hours at the temperature of 60-70 DEG C, and arranging particles by a sieve of 22 meshes; uniformly mixing the left half of the prescription amount of superfine silica gel powder with the particles and tabletting, and the weight of each tablet is 0.25g.

Description

technical field [0001] The invention relates to the field of medicines, and is a novel medicine for treating gout and secondary hyperuricemia. Background technique [0002] At present, the clinical treatment of gout is mainly based on colchicine, non-steroidal anti-inflammatory drugs, hormones, promoting uric acid excretion and inhibiting uric acid synthesis. For patients with acute attacks, colchicine and anti-inflammatory analgesics are generally used, such as: phenylbutazone or hydroxyphenylbutazone, indomethacin, ibuprofen, pylorixicam, naproxen, etc.; use in intermittent and chronic periods Drugs that promote uric acid excretion. Due to the lack of specific chemicals for the treatment of gout, domestic companies have not developed some important varieties for the treatment of gout. These drugs generally have anti-inflammatory and analgesic effects, such as: Tongfengding Capsules, Zhitong Fengshi Pills, Tongfengshu Capsules, Binhuo Tongfeng Mixture , Tongfengding Table...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/519A61K31/343A61K9/20A61P19/06
Inventor 李鸿钱友生
Owner HUBEI GUANGREN PHARMACEUTICAL CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap