Medicament for treating dyspepsia and preparation thereof

A technology for indigestion and drugs, which is applied in the direction of digestive system, drug combination, drug delivery, etc., and can solve problems such as complex and mutually damaging preparation processes

Inactive Publication Date: 2008-07-02
GUANGDONG ZHONGSHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Chinese patent ZL02803889.4 describes a new microbial enzyme mixture, which contains concentrated Rhizopus delemar lipase, Aspergillus mell...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0114] Embodiment 1 compound amylase oral solution

[0115] prescription:

[0116] Bacillus subtilis liquefied alpha-amylase 27000 units

[0117] Hawthorn Liquid Extract Equivalent to Hawthorn 30g

[0118] Calcium pantothenate 0.1g

[0119] Niacinamide 0.1g

[0120] Vitamin B 1 0.01g

[0121] Sodium Benzoate 3g

[0122] Ethylparaben 0.5g

[0123] Caramel coloring 0.14g

[0124] Food flavor 0.6ml

[0125] Purified water add to full amount

[0126] Makes 1000ml

[0127] The preparation process is as follows:

[0128] (1) Take the prescribed amount of sodium benzoate, ethyl paraben, hawthorn fluid extract, and caramel pigment, dissolve it in an appropriate amount of purified water, heat to boiling with steam, boil for 30 minutes, and cool slightly for use.

[0129] (2) Take the prescribed amount of calcium pantothenate, nicotinamide, vitamin B 1 , Edible essence dissolved with appropriate amount of purified water.

[0130] (3) Combine the solutions...

Embodiment 2

[0134] Embodiment 2 compound amylase granules

[0135] prescription:

[0136] Bacillus subtilis liquefied alpha-amylase 90000 units

[0137] Hawthorn Liquid Extract Equivalent to Hawthorn 100g

[0138] Calcium pantothenate 0.333g

[0139] Niacinamide 0.333g

[0140] Vitamin B 1 0.033g

[0141] Appropriate amount of lactose

[0142] Moderate amount of mannitol

[0143] Food flavor 3ml

[0144] Aspartame 2g

[0145] Made into 1000g

[0146] Preparation Process:

[0147] Hawthorn liquid extract is dissolved in 40% ethanol and set aside; take amylase, calcium pantothenate, nicotinamide, vitamin B 1 , aspartame, sodium carboxymethyl starch, and microcrystalline cellulose are uniformly mixed by an equal increase method, and 100 mesh sieves are crossed, and the 40% ethanol solution that is dissolved with hawthorn fluid extract is used as a binding agent or a wetting agent to granulate, Dried, made into 1000g, sprayed with edible essence, mixed evenly, gr...

Embodiment 3

[0149] Embodiment 3 compound amylase capsules

[0150] Bacillus subtilis liquefied alpha-amylase 90000 units

[0151] Hawthorn Liquid Extract Equivalent to Hawthorn 100g Calcium Pantothenate 0.333g

[0152] Niacinamide 0.333g Vitamin B 1 0.033g

[0153] Appropriate amount of microcrystalline cellulose Dicalcium phosphate Appropriate amount

[0154] Carboxymethyl Starch Sodium 20g Talc 5g

[0155] The preparation process is as follows:

[0156] Hawthorn liquid extract is dissolved in 40% ethanol and set aside; take amylase, calcium pantothenate, nicotinamide, vitamin B 1 Mix evenly with lactose and dextrin in equal increments, pass through a 100-mesh sieve, use 40% ethanol solution dissolved in hawthorn fluid extract as a binder or wetting agent to granulate, dry, and granulate with a 14-20-mesh iron sieve , add carboxymethyl starch sodium and talcum powder and mix evenly to prepare about 600g of granules, fill and make 2000 granules in capsules, to obtain final product...

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PUM

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Abstract

The invention relates to a drug for the treatment of dyspepsia, and takes amylase, hawthorn fluid extract, calcium pantothenate, nicotinamide and vitamin B1 as the active ingredients. The preparation method is that: the hawthorn is prepared into the hawthorn fluid extract and then is dissolved in 40 percent ethanol; the amylase, the calcium pantothenate, the nicotinamide, the vitamin B1, calcium hydrophosphate and microcrystalline cellulose are taken, mixed evenly and screened; the 40 percent ethanol solution which is dissolved with the hawthorn fluid extract is used as the binding agent for granulation, drying and stabilization; the sodium starch glycolate and talc powder are added and mixed evenly for granule preparation and tablet pressing; or the prescription dose of sodium benzoate, ethyl hydroxybenzoate, hawthorn fluid extract and caramel colorant are taken to be dissolved in purified water, the steam is used for heating till boiling for 30 minutes, and then the mixture is cooled slightly for standby; the prescription dose of calcium pantothenate, nicotinamide, vitamin B1 and edible flavor are dissolved in the purified water; the solution is merged and cooled; the prescription dose of amylase is taken, dissolved in purified water and screened; the solution is merged, the purified water is added till the full amount, and the oral solution is obtained by evenly stirring and filtration.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating dyspepsia and a preparation method thereof. Background technique [0002] Chinese patent ZL02803889.4 describes a new microbial enzyme mixture, which contains concentrated Rhizopus delemar lipase, Aspergillus melleus protease and Aspergillus oryzae amylase, this enzyme mixture The preparation process is more complicated because the enzymes may destroy each other. [0003] Chinese patent 200580009314.7 discloses an oral pharmaceutical composition containing a surfactant and a lipase product, especially pancreatin. It is a lipase-containing product for oral administration, especially pancreatic enzymes and products containing pancreatic enzymes, which improves lipolytic activity and leads to stabilization of lipase, especially in the acidic pH range, and is useful in the treatment of Indigestion due to lipase deficiency. Chinese patent ZL03146129.8 discloses a compound pepsin powder fo...

Claims

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Application Information

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IPC IPC(8): A61K38/47A61K9/08A61K9/10A61K9/14A61K9/16A61K9/20A61K9/48A61P1/14A61K36/734A61K31/197A61K31/455A61K31/51
Inventor 谢称石
Owner GUANGDONG ZHONGSHENG PHARMA
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