The invention discloses a compound medicine containing letrozole and a preparation method of the compound medicine. The medicine contains the letrozole, copovidone, mannitol, cellulose, crosslinked povidone, magnesium stearate, polyethylene glycol, lactose and starch. The formula of the medicine consists of 8-20 parts of the letrozole, 80-150 parts of the copovidone, 1-3 parts of the mannitol, 4-6 parts of the cellulose, 1-2 parts of the crosslinked povidone, 1-2 parts of the magnesium stearate, 1-3 parts of the polyethylene glycol, 0.5-1 part of the lactose and 1-2 parts of the starch. The compound medicine provided by the invention can significantly improve a letrozole dissolution rate and can further improve bioavailability and clinical treatment effect of medicinal active ingredients; and in addition, a release speed can be reduced, so that the purpose of uniform administration is achieved; therefore, drug tolerance is enhanced.