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Insoluble pharmaceutical composition

A technology for insoluble drugs and compositions, applied in drug combinations, antineoplastic drugs, pharmaceutical formulations, etc., can solve the problems of cumbersome process, difficult dissolution, high equipment requirements, etc., and achieve simple preparation process, improved dissolution rate, and convenient operation Effect

Inactive Publication Date: 2010-03-17
北京华禧联合科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented method combines different ways to make sure luteinizing hormone works better with other drugs like levitazol or clonidine. By mixing these chemicals into another form before they're given up on their own, we get ridged off any impurities during manufacturing processes. Additionally, this new way makes them easier to use because there won’t have extra steps required afterward.

Problems solved by technology

This patented technical solution described in this patents relates to improving the solubility or absorption rate of certain compounds like Levitziarelate(Levey et al.) while also reducing side effects associated therewith. Specifically, we describe how small particles can be made into stable compositions without losing their original properties when added during manufacturing processes.

Method used

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  • Insoluble pharmaceutical composition
  • Insoluble pharmaceutical composition
  • Insoluble pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: Letrozole Granules

[0013] prescription:

[0014]

[0015] Preparation:

[0016] (1) Letrozole is pulverized through a 170 mesh sieve for subsequent use;

[0017] (2) All auxiliary materials are passed through an 80-mesh sieve for subsequent use;

[0018] (3) Sorbitol, dextrin, aspartame, and cross-linked polyvinylpyrrolidone are weighed and mixed uniformly to obtain material I. Letrozole is taken in an equal amount and added to material I in equal amounts, mixed uniformly to obtain material II;

[0019] (4) Add polysorbate 80 to 2% hypromellose aqueous solution to make a binder, add an appropriate amount of binder to material II to make a suitable soft material, granulate through a 24-mesh sieve, and ventilate at 50°C Dry, control the moisture to be less than 3%, and granulate with a 20-mesh sieve.

[0020] (5) Add orange essence to the dry granules, mix evenly, and pack.

Embodiment 2

[0021] Embodiment 2: letrozole tablet

[0022] prescription:

[0023]

[0024] Preparation:

[0025] (1) Letrozole is pulverized through a 200-mesh sieve for subsequent use;

[0026] (2) All auxiliary materials are passed through a 100-mesh sieve for subsequent use;

[0027] (3) Lactose, starch, microcrystalline cellulose, sodium carboxymethyl starch that take by weighing recipe quantity mix homogeneously, obtain material I, take by weighing letrozole and sodium lauryl sulfate of recipe quantity mix, add material in equal amount I, mix homogeneously, obtain material II;

[0028] (4) Add appropriate amount of material II to 10% starch slurry to make a suitable soft material, pass through a 20-mesh sieve to granulate, ventilate and dry at 50°C, control the moisture content to be less than 3%, and granulate with a 20-mesh sieve.

[0029] (5) Add magnesium stearate to the dry granules, mix evenly, compress into tablets, and pack.

Embodiment 3

[0030] Embodiment 3: Letrozole capsules

[0031] prescription:

[0032]

[0033] Preparation:

[0034] (1) Letrozole is pulverized through a 150-mesh sieve for subsequent use;

[0035] (2) All auxiliary materials are passed through an 80-mesh sieve for subsequent use;

[0036] (3) Mannitol, pregelatinized starch, croscarmellose sodium, and low-substituted hydroxypropyl cellulose fillers are weighed and mixed uniformly to obtain material I, and letrozole and poloxa are taken in prescription quantities Mud and Polyethylene Glycol 6000 were mixed evenly, and the same amount was added to the material I, and the mixture was evenly mixed to obtain the material II;

[0037] (4) Fill capsules with the material II, and pack.

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Abstract

The invention discloses an insoluble pharmaceutical composition which contains letrozole as pharmaceutical active ingredient; the composition is added with a surfactant and reduces the particle size of the letrozole; and the joint effect of both greatly improves the dissolution of the letrozole. The insoluble pharmaceutical composition has the advantages of simple preparation process, no need forspecial equipment, convenient operation and good suitability for industrial production.

Description

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Claims

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Application Information

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Owner 北京华禧联合科技发展有限公司
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