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Capsule containing palbociclib and preparation method of capsule

A kind of capsule and lubricant technology, applied in the field of Palbociclib capsules

Inactive Publication Date: 2017-07-07
BEIJING XINLINGXIAN MEDICAL TECH DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, no preparation patent about palbociclib has been found. The present invention provides a capsule containing palbociclib and a preparation method thereof

Method used

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  • Capsule containing palbociclib and preparation method of capsule
  • Capsule containing palbociclib and preparation method of capsule
  • Capsule containing palbociclib and preparation method of capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: preparation embodiment

[0021]

[0022]

[0023] Preparation Process:

[0024] 1. Pulverize the crude drug through a 100-mesh sieve;

[0025] 2. Mix the raw material medicine with microcrystalline cellulose, lactose, sodium carboxymethyl starch, silicon dioxide and 1 / 2 amount of magnesium stearate, dry granulate, and pass through a 20-mesh sieve;

[0026] 3. Add the remaining amount of magnesium stearate to the above mixture, mix well, and fill the capsules.

Embodiment 2

[0027] Embodiment 2: preparation embodiment

[0028]

[0029] Preparation Process:

[0030] 1. Pulverize the crude drug through a 100-mesh sieve;

[0031] 2. Mix the raw material drug with microcrystalline cellulose, lactose, sodium carboxymethyl starch, magnesium stearate and 1 / 2 amount of silicon dioxide, dry granulate, and pass through a 20-mesh sieve;

[0032] 3. Add the remaining amount of silicon dioxide to the above mixture, mix well, and fill the capsules.

Embodiment 3

[0033] Embodiment 3: preparation embodiment

[0034]

[0035] Preparation Process:

[0036] 1. Pulverize the crude drug through a 100-mesh sieve;

[0037] 2. Mix the raw material drug with microcrystalline cellulose, lactose, sodium carboxymethyl starch and 2 / 3 of the amount of silicon dioxide, dry granulate, and pass through a 20-mesh sieve;

[0038] 3. Add the remaining amount of silicon dioxide to the above mixture, mix well, and fill the capsules.

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Abstract

The invention relates to a capsule containing palbociclib and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. This product can be used in combination with letrozole for patients with advanced breast cancer. The capsule contains palbociclib, diluent, disintegrant and lubricant, wherein the mass ratio of palbociclib is 10% to 40%, and the mass ratio of diluent is 30% to 80%, The mass proportion of the disintegrating agent is 1%-10%, and the consumption amount of the lubricant is 0.5-5%. In addition, the present invention also discloses a method for preparing palbociclib capsules. The palbociclib capsules prepared by the method of the present invention have simple process and operation, and are particularly suitable for industrial production. The prepared The palbociclib capsule has good stability and good dissolution rate.

Description

technical field [0001] The invention relates to a palbociclib capsule, specifically, a capsule containing palbociclib. The invention also relates to a preparation method of palbociclib capsules. The palbociclib capsule prepared by the method of the invention has simple process and operation, is particularly suitable for industrial production, and the prepared palbociclib capsule has good stability and good dissolution rate. Background technique [0002] Breast cancer is one of the most common malignant tumors in women. The incidence rate accounts for 7-10% of all kinds of malignant tumors in the whole body. It is second only to uterine cancer in women. Its incidence is often related to heredity. The etiology of breast cancer is not yet fully understood. Studies have found that there is a certain regularity in the incidence of breast cancer, and women with high-risk factors for breast cancer are prone to breast cancer. Early detection and diagnosis of breast cancer is the k...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/519A61P35/00
CPCA61K31/519A61K9/4866
Inventor 黄慧玲
Owner BEIJING XINLINGXIAN MEDICAL TECH DEV CO LTD
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