Compound medicine containing letrozole and preparation method of compound medicine
A technology of letrozole and compound prescription is applied in the field of compound medicine of letrozole and its preparation, which can solve the problems of unsuitability for industrialized production, low dissolution rate of preparation, and little improvement, etc., and achieves improved bioavailability and clinical Therapeutic effect, the preparation method is simple and easy, and the effect of slowing the release rate
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Embodiment 1
[0016] Mix 8 parts of letrozole with 80 parts of copovidone, put them into a hot-melt extruder, control the heating temperature at 120-140°C, adjust the discharge speed so that the material stays in the heating part of the equipment for 20-60 seconds, Cut the extrudate into small pieces and cool it down; take 100 parts of the cooled solid, mix with 1 part of mannitol, 4 parts of cellulose, and 1 part of crospovidone, mix well, moisten with water, granulate, and control the particle diameter 0.5 ~ 2mm, dried at 30 ~ 35 ° C for more than 12 hours, then mixed with 1 part of magnesium stearate, compressed into tablets.
Embodiment 2
[0018] Mix 20 parts of letrozole with 150 parts of copovidone, put it into a hot-melt extruder, control the heating temperature at 120-140°C, adjust the discharge speed so that the material stays in the heating part of the equipment for 20-60 seconds, Cut the extrudate into small pieces and cool it down; take 200 parts of the cooled solid, mix with 1-3 parts of mannitol, 6 parts of cellulose, and 2 parts of crospovidone, mix well, moisten with water, granulate, control The particle diameter is 0.5-2mm, dried at 30-35°C for more than 12 hours, then mixed evenly with 2 parts of magnesium stearate, and pressed into tablets.
Embodiment 3
[0020] Mix 8 parts of letrozole with 150 parts of copovidone, put them into a hot-melt extruder, control the heating temperature at 120-140°C, adjust the discharge speed so that the material stays in the heating part of the equipment for 20-60 seconds, Cut the extrudate into small pieces and cool it down; take 200 parts of the cooled solid, mix with 1 part of mannitol, 4 parts of cellulose, and 2 parts of cross-linked povidone, mix well, moisten with water, granulate, and control the particle diameter 0.5-2mm, dried at 30-35°C for more than 12 hours, then mixed with 2 parts of magnesium stearate evenly, and pressed into tablets.
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