Medicine for treating child influenza and preparation method thereof

A drug and children's technology, which is applied in the field of treating children's cold medicine and its preparation, can solve the problems of troublesome treatment and large volume of patients

Inactive Publication Date: 2012-06-20
山西皇城相府药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to statistical data, there are very few professional children's pharmaceutical factories in my country's pharmaceutical market at present, and the proportion of sick children in my country accounts for about 20% of the total sick population. less than 2% of children treated
[0004] 2. In terms of dosage forms, among the more than

Method used

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  • Medicine for treating child influenza and preparation method thereof
  • Medicine for treating child influenza and preparation method thereof
  • Medicine for treating child influenza and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0082] Weigh the raw materials according to the following ratio:

[0083] Paracetamol 80g, pseudoephedrine hydrochloride 7.5g, chlorpheniramine maleate 0.5g,

[0084] 44g of microcrystalline cellulose, 21.5g of starch, 8g of aspartame, 9g of sodium starch glycolate, 0.8g of magnesium stearate, 6.7g of 60% ethanol and 25g of 2% aqueous solution of sodium starch glycolate are used as auxiliary materials.

[0085] Specific preparation method:

[0086] 1) Paracetamol, pseudoephedrine hydrochloride, and chlorpheniramine maleate are respectively pulverized into fine powders for subsequent use;

[0087] 2) Mix chlorpheniramine maleate with acetaminophen and pseudoephedrine hydrochloride uniformly in an equal increment method;

[0088] 3) Weigh 24 g of microcrystalline cellulose, 19.5 g of starch, 8 g of aspartame, and 1 g of sodium starch glycolate, mix them uniformly, crush and sieve, and mix uniformly with the product obtained in step 2);

[0089] 4) Add 60% ethanol 6.7g and 2% ...

Embodiment 2

[0093] Weigh the raw materials according to the following ratio:

[0094] Acetaminophen 70g, pseudoephedrine hydrochloride 6g, chlorpheniramine maleate 0.3g,

[0095] 44g of microcrystalline cellulose, 21.5g of starch, 8g of aspartame, 9g of sodium starch glycolate, 0.8g of magnesium stearate, 6.7g of 60% ethanol and 25g of 2% aqueous solution of sodium starch glycolate are used as auxiliary materials.

[0096] Specific preparation method:

[0097] 1) Paracetamol, pseudoephedrine hydrochloride, and chlorpheniramine maleate are respectively pulverized into fine powders for subsequent use;

[0098] 2) Mix chlorpheniramine maleate with acetaminophen and pseudoephedrine hydrochloride uniformly in an equal increment method;

[0099] 3) Weigh 24 g of microcrystalline cellulose, 19.5 g of starch, 8 g of aspartame, and 1 g of sodium starch glycolate, mix them uniformly, crush and sieve, and mix uniformly with the product obtained in step 2);

[0100] 4) Add 60% ethanol 6.7g and 2% ...

Embodiment 3

[0104] Weigh the raw materials according to the following ratio:

[0105] Paracetamol 75g, pseudoephedrine hydrochloride 7g, chlorpheniramine maleate 0.4g,

[0106] 44g of microcrystalline cellulose, 21.5g of starch, 8g of aspartame, 9g of sodium starch glycolate, 0.8g of magnesium stearate, 6.7g of 60% ethanol and 25g of 2% aqueous solution of sodium starch glycolate are used as auxiliary materials.

[0107] Specific preparation method:

[0108] 1) Paracetamol, pseudoephedrine hydrochloride, and chlorpheniramine maleate are respectively pulverized into fine powders for subsequent use;

[0109] 2) Mix chlorpheniramine maleate with acetaminophen and pseudoephedrine hydrochloride uniformly in an equal increment method;

[0110] 3) Weigh 24 g of microcrystalline cellulose, 19.5 g of starch, 8 g of aspartame, and 1 g of sodium starch glycolate, mix them uniformly, crush and sieve, and mix uniformly with the product obtained in step 2);

[0111] 4) Add 60% ethanol 6.7g and 2% ca...

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PUM

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Abstract

The invention relates to a medicine for treating child influenza, which takes acetaminophen, pseudoephedrine hydrochloride and chlorphenamine maleate as main materials, and takes microcrystalline cellulose, starch, aspartame, sodium starch glycolate, magnesium stearate, 60% ethanol and 2% sodium starch glycolate aqueous solution as auxiliary materials. A preparation method is as follows: the acetaminophen, the pseudoephedrine hydrochloride and the chlorphenamine maleate are crushed into fine powder for spare use; the chlorphenamine maleate is uniformly mixed with the acetaminophen and the pseudoephedrine hydrochloride through a equivalent incremental method; parts of the microcrystalline cellulose, the starch, the aspartame and the sodium starch glycolate are weighed to be uniformly mixed, are crushed to sieve, and are mixed again, the 60% ethanol and the 2% sodium starch glycolate aqueous solution are added to the prepared mixture, are completely stirred to make a soft material, and wet particles are produced after the sieving; the produced wet particles are dried at 75 DEG C and granulated; after the granulation, the residual auxiliary materials of the microcrystalline cellulose, the starch, the sodium starch glycolate and the magnesium stearate are added again to mix uniformly; and dispersible tablets are pressed and packaged. The medicine has the advantages of obvious curative effect, good safety, convenience in medicine taking and suitable taste for children.

Description

technical field [0001] The invention relates to a medicament, in particular to a medicament for treating colds in children prepared by using chemical medicine as a raw material and a preparation method thereof. Background technique [0002] 1. From the perspective of the market environment and target groups, surveys have shown that among children under the age of 12, taking Western medicine to treat colds is still the first choice, and dispersants and syrup preparations with good taste are the most popular. Compared with adult cold medicines, the children's cold medicine market is relatively small, and there are relatively few brands to choose from; except for well-known brands such as Hutong and Eucadan, most of the common children's cold medicines are based on the successful experience of adult cold medicines generated on the basis of The most significant difference and characteristic between adult cold medicine and children's cold medicine is the ingredients and dosage. ...

Claims

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Application Information

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IPC IPC(8): A61K31/4402A61K31/167A61K31/137A61P11/00A61P29/00A61P11/06
Inventor 赵荷英
Owner 山西皇城相府药业股份有限公司
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