Absorbable composite styptic powder and preparation method thereof

A technology of hemostatic powder and mixed powder, applied in the field of medicine, can solve the problems of no antibacterial effect, promoting wound healing, slow absorption of gelatin, and increasing the risk of wound infection, so as to improve plasma osmotic pressure, reduce tissue edema, and protect nerves. The effect of the tip

Inactive Publication Date: 2017-10-13
广西达庆生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the clinically used hemostatic materials mainly include fibrin glue, collagen, gelatin sponge and cellulose hemostatic materials. These materials have achieved good results in animal experiments and clinical applications, but there are also some shortcomings: The raw material is derived from animal tissue, which is a foreign protein, which is prone to rejection and has potential sensitization; gelatin absorbs slowly, generally more than 4 weeks, which will increase the risk of wound infection; cellulose, the human body lacks enzymes to degrade it , the d

Method used

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  • Absorbable composite styptic powder and preparation method thereof
  • Absorbable composite styptic powder and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0030] Absorbable compound hemostatic powder of the present invention, raw material consumption is:

[0031] Carboxymethyl chitosan 10g, sodium alginate 10g, sodium carboxymethylcellulose 10g, sodium starch glycolate 15g, mannitol 30g, calcium chloride 1g, distilled water 2000g.

[0032] The preparation method of absorbable compound hemostatic powder of the present invention is:

[0033] A, take carboxymethyl chitosan, sodium alginate, carboxymethyl cellulose sodium, carboxymethyl starch sodium powder respectively, mix uniformly, get mixed powder A;

[0034] B. Weigh distilled water, and add the mixed powder described in step A into distilled water while stirring until completely dissolved to obtain solution B;

[0035] C, weigh mannitol, add in the solution B, stir evenly, get the solution C;

[0036] D. The solution C is freeze-dried, and the freeze-dried sample is pulverized and passed through a 60-mesh sieve to obtain a mixed powder D;

[0037] E. Weigh calcium chloride...

Embodiment 2

[0039] Absorbable compound hemostatic powder of the present invention, raw material consumption is:

[0040]Carboxymethyl chitosan 15g, sodium alginate 15g, sodium carboxymethyl cellulose 12g, sodium starch glycolate 20g, mannitol 30g, calcium chloride 2g, distilled water 2500g.

[0041] The preparation method of absorbable compound hemostatic powder of the present invention is:

[0042] A, take carboxymethyl chitosan, sodium alginate, carboxymethyl cellulose sodium, carboxymethyl starch sodium powder respectively, mix uniformly, get mixed powder A;

[0043] B. Weigh distilled water, and add the mixed powder described in step A into distilled water while stirring until completely dissolved to obtain solution B;

[0044] C, weigh mannitol, add in the solution B, stir evenly, get the solution C;

[0045] D. The solution C is freeze-dried, and the freeze-dried sample is pulverized and passed through a 70-mesh sieve to obtain a mixed powder D;

[0046] E. Weigh calcium chloride...

Embodiment 3

[0048] Absorbable compound hemostatic powder of the present invention, raw material consumption is:

[0049] Carboxymethyl chitosan 20g, sodium alginate 20g, sodium carboxymethyl cellulose 15g, sodium starch glycolate 25g, mannitol 35g, calcium chloride 3g, distilled water 2800g.

[0050] The preparation method of absorbable compound hemostatic powder of the present invention is:

[0051] A, take carboxymethyl chitosan, sodium alginate, carboxymethyl cellulose sodium, carboxymethyl starch sodium powder respectively, mix uniformly, get mixed powder A;

[0052] B. Weigh distilled water, and add the mixed powder described in step A into distilled water while stirring until completely dissolved to obtain solution B;

[0053] C, weigh mannitol, add in the solution B, stir evenly, get the solution C;

[0054] D. The solution C is freeze-dried, and the freeze-dried sample is pulverized and passed through an 80-mesh sieve to obtain a mixed powder D;

[0055] E. Weigh calcium chlori...

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Abstract

The invention discloses absorbable composite styptic powder which is prepared from the following raw materials in parts by weight: 10-30 parts of carboxymethyl chitosan, 10-30 parts of sodium alginate, 10-20 parts of sodium carboxymethylcellulose, 15-50 parts of sodium starch glycolate, 30-60 parts of mannitol, 1-5 parts of calcium chloride and 2,000-4,000 parts of distilled water. The absorbable composite styptic powder disclosed by the invention does not contain any toxic chemical agent and has the functions of inhibiting bacteria, promoting wound healing and inhibiting scar formation; after the absorbable composite styptic powder is scattered and applied, moisture in blood can be uniformly and quickly absorbed by the absorbable composite styptic powder, and a 'white core' is not formed, therefore, the absorbable composite styptic powder is styptic powder which is convenient to use, high in efficiency and extremely good in styptic effect and has no side effect.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to an absorbable compound hemostatic powder and a preparation method thereof. Background technique [0002] With the continuous advancement of medical technology, new medical materials and related technologies have been well developed. Among them, the development and improvement of hemostatic materials are conducive to improving the problems of surgical bleeding and bleeding, which is of great significance and has become a hot research topic in the field of medicine. [0003] War wounds, trauma, emergency animal husbandry and surgical operations will all cause bleeding. This problem needs to be solved urgently. The normal human body has the function of hemostasis. Slow and small amount of bleeding can stop bleeding by relying on its own function. The body cannot stop the bleeding by itself, nor can it only rely on ordinary hemostatic bandages to stop the bleeding. If the patient loses too m...

Claims

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Application Information

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IPC IPC(8): A61L24/08A61L24/02A61L24/00
Inventor 梁文棋
Owner 广西达庆生物科技有限公司
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