Cefetamet pivoxil hydrochloride dispersible tablet and preparation method thereof

A technology of ceftazidime hydrochloride and dispersible tablets, which is applied in the field of medicine, can solve the problems of large capsule size, etc., and achieve the effects of high bioavailability, fast absorption and less adverse reactions

Inactive Publication Date: 2013-01-09
ZHEJIANG KAIRUN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to solve the technical defects that ordinary tablets and capsules are large in size and not suitable for infants and patients with dysphagia, an object of the present invention is to pr...

Method used

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  • Cefetamet pivoxil hydrochloride dispersible tablet and preparation method thereof
  • Cefetamet pivoxil hydrochloride dispersible tablet and preparation method thereof
  • Cefetamet pivoxil hydrochloride dispersible tablet and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0027]

[0028]

[0029] Such as figure 1 Shown, above-mentioned raw material prepares ceftazidime hydrochloride dispersible tablet by the following method:

[0030] 1) Pretreatment of raw and auxiliary materials: ceftametexil hydrochloride, microcrystalline cellulose, crospovidone, calcium hydrogen phosphate, sodium carboxymethyl starch, silicon dioxide, magnesium stearate, stevioside all passed 60~ 80 mesh sieve;

[0031] 2) Granulation: Accurately weigh the sieved ceftazidime hydrochloride, crospovidone, and calcium hydrogen phosphate, pour them into a high-efficiency wet mixing granulator, set the stirring frequency to 40Hz, and start stirring and mixing for 3~5min After the mixing is completed, add purified water, set the chopping frequency to 45HZ, start chopping and granulating, and discharge;

[0032] 3) Drying: Spread the wet granules obtained from granulation evenly on the drying pan of the drying car, set the temperature at 50-65°C, and the total drying time...

Embodiment 2

[0039]

[0040]

[0041] Above-mentioned raw material prepares ceftazidime hydrochloride dispersible tablet by the method described in embodiment 1.

Embodiment 3

[0043]

[0044] Above-mentioned raw material prepares ceftazidime hydrochloride dispersible tablet by the method described in embodiment 1.

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Abstract

The invention relates to the medical field, in particular to a cefetamet pivoxil hydrochloride dispersible tablet and a preparation method thereof. The cefetamet pivoxil hydrochloride dispersible tablet is prepared by the following components, by weight: 40-60% of cefetamet pivoxil hydrochloride, 10-20% of microcrystalline cellulose, 5-15% of polyvinylpolypyrrolidone, 5-12% of calcium hydrophosphate, 5-15% of sodium starch glycolate, 0.5-5% of silicon dioxide, 0.5-5% of magnesium stearate, 0.01-0.2% of steviosin and a proper amount of water. Compared with the ordinary tablets and capsules, the cefetamet pivoxil hydrochloride dispersible tablet has the advantages of being good in dispersing state, short in disintegration time, fast in medicine dissolution and absorption, high in bioavailability, few in bar reaction, convenient to take and the like.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a ceftazidime hydrochloride dispersible tablet and a preparation method thereof. Background technique [0002] Ceftazidime hydrochloride is an oral third-generation cephalosporin drug developed by Swiss Hoffmann Roche Company in the late 1970s. This product was first listed in Mexico in 1992. The name Globocef. [0003] Ceftazidime pivoxil hydrochloride has good antibacterial activity against most Gram-negative bacteria and some positive bacteria, and is stable against a variety of β-lactamases produced by bacteria, with strong tissue penetration and anti-inflammatory ability to the body. Positive regulatory effect. [0004] The active ingredient in ceftazidime pivoxil hydrochloride must be orally hydrolyzed into ceftazime pivoxil to produce antibacterial activity. The dosage forms of the medicine sold in the market are mainly ordinary tablets and capsules. The disintegration and rele...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/546A61K47/38A61P31/04A61P29/00
Inventor 郝晋
Owner ZHEJIANG KAIRUN PHARMA
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