6 results about "Urological Diseases" patented technology

This invention relates to pyrimidin-4(3H)-one derivatives of formula (I),that act as modulators of the TRPV4 receptor. The present invention also relates to processes for the preparation of novel pyrimidin-4(3H)-one derivatives of formula (I) and to their use in the treatment of a wide range of diseases, syndromes, and disorders, in particular, for the treatment of inflammation, pain, and urological diseases or disorders.

This invention discloses a traditional Chinese medicine formula for preventing and treating feline urinary tract diseases, its preparation method, and its application. The formula consists of the following components in parts by weight: 15-25 parts of Psoralea corylifolia, 15-25 parts of Alpinia oxyphylla, 10-20 parts of Trigonella foenum-graecum, 5-15 parts of Zea mays, 5-15 parts of Juncus effusus, 10-20 parts of Dioscorea hypoglauca, 10-20 parts of Phellodendron chinense, 10-20 parts of Lonicera japonica, 5-15 parts of Paeonia lactiflora, and 5-15 parts of Glycyrrhiza uralensis. The traditional Chinese medicine formula provided by this invention has diuretic and urinary tract mucosal repairing effects. It can effectively relieve symptoms such as urinary stones, painful urination, hematuria, or gravel in the urine caused by damp-heat in the lower abdomen. It promotes the repair of the urinary tract mucosa in animals with urinary tract diseases, alleviates inflammatory responses, and prevents the formation of crystals in the urine.

This invention relates to the field of urological disease technology and provides an implantable urination device, including a valve that can be placed in the obstructed bladder outflow tract, a drive wire that can be partially placed in the urinary tract and partially placed in the scrotum, and a control unit that can be placed in the scrotum. The control unit controls the drive wire to open or close the valve. This implantable urination device, for patients with chronic urinary retention caused by long-term bladder outflow tract obstruction, allows for minimally invasive, simple, and non-exposed treatment by implanting a valve in the bladder outflow tract and placing a control unit in the scrotum that can control the drive wire to open or close the valve. This improves the patient's quality of life, regulates their psychological state, and promotes their physical and mental health.

The invention relates to the technical field of medicine, and discloses medical wearable equipment for acquiring multimodal data of urinary system diseases, which comprises the aspects of inspection technology, imaging technology, health data science and the like. Comprising a wearable main body module, a multi-modal data acquisition module, a data preprocessing and standardization module, a data transmission and encryption module, an equipment control and interaction module and a hospital system linkage module, the wearable main body module provides physical support and stable power supply for the equipment. By adopting the technical scheme of fusing images, clinical diagnosis, physiological parameters and omics analysis and combining a hierarchical fusion strategy and cross-modal data standardization processing, the technical effects of comprehensively describing urinary system disease characteristics and providing complete data support for a prediction model are achieved; and the defects of one-sided prediction result and limited accuracy caused by single data dimension and high heterogeneity are overcome.

This invention discloses a method for collaborative registration and alignment of multi-target curve medical images of the female pelvic floor, comprising: S1: marking the target curve, SCIPP line, and segmentation markers in each sample data; S2: using a dimensionality reduction method combining Y-Z plane projection and X-coordinate dynamic compensation to reduce the dimensionality of the three-dimensional medical data to two dimensions; S3: smoothing the curves using cubic spline interpolation before registration to avoid the influence of noise in the original data on the registration accuracy; S4: calculating the translation matrix based on the reference point of the SCIPP line at the lower edge of the pubic symphysis, and aligning the lower edge of the first reference point at the lower edge of the pubic symphysis. S5: Move to the origin; S6: Use the SCIPP line as a reference vector and calculate the rotation matrix using the difference between the reference vector and the target angle; S7: Apply the corresponding translation and rotation matrices to the corresponding sample curve data to establish a unified coordinate system; S8: Calculate the average value of the curve segment based on the marker points, and then combine the average values ​​calculated segment by segment into the average value of the entire curve; S9: Calculate the centroid, local centroid, and global centroid of each curve, and translate the centroid of the corresponding curve to coincide with the local and global centroids of the corresponding curve to achieve alignment. This invention realizes the standardized registration, two-dimensional alignment, and anatomical segmented averaging analysis of female pelvic organ contour curve data, providing accurate quantitative basis for the diagnosis and clinical research of urological diseases.

Embodiments of the present invention provide a device and a method for treating at least one of hypertension, pulmonary arteries, diabetes, obesity, heart failure, end-stage renal disease, digestive disease, urological disease, cancers, tumors, pain, asthma or chronic obstructive pulmonary disease by delivering an effective amount of a formulation to a tissue. In embodiments of the present invention, the formulation may include at least one of a gas, a vapor, a liquid, a solution, an emulsion, or a suspensions of one or more ingredients. In embodiments of the present invention, amounts of the formulation and / or energy are effective to injure or damage tissue, nerves, and nerve endings in order to relieve disease symptoms.