Liver aid troche and preparation method thereof

A technology for Yiganling tablets and tablets, which are applied in the directions of pill delivery, pharmaceutical formulations, and medical preparations with inactive ingredients, etc., can solve the problems of uneven surface, unfavorable large-scale production, and low yield, and achieve a one-sided solution. The effect of unevenness, reducing the generation of waste and improving production efficiency

Inactive Publication Date: 2012-06-13
SHANGHAI ZHAOHUI PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] However, the products produced under the existing prescription and process conditions are not conducive to the smooth progress of large-scale production due to the large weight difference in the tableting process
At the same time, a large number of subdivisions are produced during coating, the surface finish is poor, the surface is uneven, pitting is easy, there are many waste products, and the yield is low. Therefore, it needs to be improved.

Method used

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  • Liver aid troche and preparation method thereof
  • Liver aid troche and preparation method thereof
  • Liver aid troche and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0036] Example 1 prepares Yiganling tablet:

[0037]

[0038] (1) Silymarin sieved with 60 mesh, calcium hydrogen phosphate with 60 mesh, starch with 100 mesh, calcium sulfate with 18 mesh, sucrose crushed with 80 mesh, carboxymethyl starch sodium with 100 mesh, magnesium stearate with 100 mesh Sieve for use;

[0039] (2) Preparation of 15% starch slurry: put 2.0 g of starch into a stainless steel slurry mixing tank, add 11.3 g of purified water, stir until it reaches a concentration of 15%, and set aside.

[0040] (3) Put the standby silymarin, calcium hydrogen phosphate, calcium sulfate, sucrose and starch in step (1) into a high-speed wet granulator in turn, after stirring for 5 minutes, add the starch slurry prepared in step (2), and stir for 3 minutes to obtain wet particles;

[0041] (4) The wet granules prepared in step (3) are granulated with a 18-mesh nylon net in a swing machine, and after drying in an oven at 60 to 65° C. for 2.5 hours, granulate with a 18-mesh...

example 2

[0045] Example 2 prepares Yiganling tablet:

[0046]

[0047] (1) Silymarin sieved with 60 mesh, calcium hydrogen phosphate with 60 mesh, starch with 100 mesh, calcium sulfate with 18 mesh, sucrose crushed with 80 mesh, carboxymethyl starch sodium with 100 mesh, magnesium stearate with 100 mesh Sieve for use;

[0048] (2) Preparation of 15% starch slurry: put 2.2 g of starch into a stainless steel slurry mixing tank, add 12.5 g of purified water, stir until it reaches a concentration of 15%, and set aside.

[0049] (3) Put the standby silymarin, calcium hydrogen phosphate, calcium sulfate, sucrose and starch in step (1) into a high-speed wet granulator in turn, after stirring for 5 minutes, add the starch slurry prepared in step (2), and stir for 3 minutes to obtain wet particles;

[0050] (4) The wet granules prepared in step (3) are granulated with a 18-mesh nylon mesh of a swing machine, and after drying in an oven at 65 to 70° C. for 2 hours, granulated with a 18-mesh...

example 3

[0054] Example 3 prepares Yiganling tablet:

[0055]

[0056] (1) Silymarin sieved with 60 mesh, calcium hydrogen phosphate with 60 mesh, starch with 100 mesh, calcium sulfate with 18 mesh, sucrose crushed with 80 mesh, carboxymethyl starch sodium with 100 mesh, magnesium stearate with 100 mesh Sieve for use;

[0057] (2) Preparation of 15% starch slurry: put 2.5 g of starch into a stainless steel slurry mixing tank, add 14.2 g of purified water, stir until it reaches a concentration of 15%, and set aside.

[0058] (3) Put the standby silymarin, calcium hydrogen phosphate, calcium sulfate, sucrose and starch in step (1) into a high-speed wet granulator in turn, after stirring for 5 minutes, add the starch slurry prepared in step (2), and stir for 3 minutes to obtain wet particles;

[0059] (4) The wet granules prepared in step (3) are granulated with a 18-mesh nylon mesh of a swing machine, and after drying in an oven at 70 to 75° C. for 1.5 hours, granulated with a 18-me...

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Abstract

The invention provides a liver aid troche, which is characterized by comprising the following components in weight ratio: in each 1000 troches: 60 g of silymarin, 55-65 g of calcium hydrophosphate, 70-80 g of calcium sulphate, 35-45 g of cane sugar, 6.0-6.2 g of starch added with 2.0-2.5 g of starch slurry which is 15%, 10-14 g of sodium starch glycolate, 1-2.0 g of magnesium stearate, and 7.5-8.5 g of Opadry. The liver aid troche disclosed by the invention is formed by adopting a novel preparation method and screening a more appropriate formula; therefore, the weight difference in the tabletting process meets the requirement, and mass production is smooth to carry out; simultaneously, the phenomena of being uneven in troche surface, pocked and broken after troches are coated can be solved; the rejection rate is reduced; the production efficiency is increased; and the method disclosed by the invention is simple, free from addition of new cost, easy for scale production and higher in application value.

Description

technical field [0001] The invention relates to a pharmaceutical preparation, in particular to a preparation method of the medicine, in particular to a Yiganling tablet and a preparation method thereof. Background technique [0002] Yiganling, also known as silymarin (a drug containing silymarin), has a good curative effect on acute and chronic hepatitis, early cirrhosis, toxic hepatitis, fatty liver, drug-toxic liver damage and alcoholic liver damage. It has good anti-tuberculosis effect, is cheap, and basically has no toxic and side effects. Yiganling preparations currently on the market are Yiganling Tablets, Yiganling Capsules, and Yiganling Dropping Pills. Yiganling Tablets are widely used clinically. [0003] The preparation method of existing Yiganling tablet is as follows: [0004] 1. Formula [0005] [0006] 2. Preparation process [0007] 1. Silymarin is sieved with 60 mesh, calcium hydrogen phosphate is sieved with 60 mesh, starch is sieved with 100 mesh,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/357A61K47/38A61P1/16
Inventor 王燕包玉林
Owner SHANGHAI ZHAOHUI PHARMA
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