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Glimepiride tablet and preparation method thereof

A glimepiride tablet and tablet compression technology, applied in the field of medicine, can solve the problems of unsatisfactory quality of glimepiride tablets, easy generation of impurities, increase of adverse drug reactions, etc., and achieve better dissolution effect and less impurities , the effect of high economic and social significance

Inactive Publication Date: 2017-02-01
SHIJIAZHUANG HUAXIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the quality of glimepiride tablets is still not ideal, and impurities are likely to be produced, which will increase the occurrence of adverse drug reactions. Meurea Tablets

Method used

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  • Glimepiride tablet and preparation method thereof
  • Glimepiride tablet and preparation method thereof
  • Glimepiride tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1 prepares the glimepiride tablet of the present invention

[0014] Prescription, see Table 1:

[0015] Table 1 Example 1 prescription component list

[0016] Material name Dosage (g) / 1000 tablets Glimepiride (g) 1 Lactose (g) 74 Microcrystalline Cellulose (g) 3.2 Sodium starch glycolate (g) 4.25 Povidone K30(g) 1.7 Magnesium stearate (g) 0.85

[0017] Preparation:

[0018] (1) Add 10 g of crude glimepiride to 500 mL of chloroform, heat to reflux to dissolve, then add 100 mL of tetrahydrofuran and 50 mL of tributylmethyl ether to the solution to form a mixed solvent system, then cool down to 0°C for cooling and crystallization, filter, and diethyl ether Washing and vacuum drying at 80°C gave 9.78g of glimepiride with a yield of 97.8%;

[0019] (2) Weigh the prescription amount of glimepiride obtained in step (1), add it to lactose in a weight ratio of 1:2, and finally add the prescription amount of microc...

Embodiment 2

[0033] Embodiment 2 prepares the glimepiride tablet of the present invention

[0034] For prescription, see Table 4.

[0035] Table 4 Example 2 prescription component list

[0036]

[0037] The preparation method is the same as that in Example 1, and the obtained XRPD spectrum data, differential scanning calorimetry chart data, hygroscopicity test data, and fluidity comparison data are the same as in Example 1.

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PUM

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Abstract

The invention relates to a glimepiride tablet and a preparation method thereof, belonging to the technical field of medicine. The glimepiride tablet is prepared from the following components in parts by weight: 1-2 parts of glimepiride, 74-128 parts of lactose, 3.2-6.4 parts of microcrystalline cellulose, 4.25-8.5 parts of sodium starch glycolate, 1.7-3.4 parts of povidone K30 and 0.85-1.7 parts of magnesium stearate. The glimepiride tablet provided by the invention enhances the bioavailability, thereby enhancing the curative effect. The glimepiride tablet has the advantages of higher stability, better leaching effect and higher unit-dosage use efficiency, provides a good option for medicine selection and clinical application in hospitals, and has very high economic and social meanings.

Description

technical field [0001] The invention relates to a tablet and a preparation method thereof, in particular to a glimepiride tablet and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Glimepiride is a second-generation sulfonylurea antidiabetic drug that inhibits hepatic glucose synthesis, promotes the uptake of peripheral glucose by muscle tissue, and promotes insulin secretion. This product is suitable for type 2 diabetic patients whose blood sugar cannot be fully controlled by simple diet control, exercise therapy and weight loss. Not for use in type 1 diabetes, diabetic ketosis, and prediabetic coma or coma treatment. At present, the quality of glimepiride tablets is still not ideal, and impurities are likely to be produced, which will increase the occurrence of adverse drug reactions. Meurea Tablets. Contents of the invention [0003] The purpose of the present invention is to overcome the defects of the prior ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K47/38A61K47/36A61K47/32A61K47/26A61K47/12A61K31/64A61P3/10
CPCA61K9/2059A61K9/2013A61K9/2018A61K9/2027A61K9/2054A61K31/64
Inventor 李志鹏李明海周如亮马海波
Owner SHIJIAZHUANG HUAXIN PHARMA
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