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Four-colored granular Keteling capsules and preparation method thereof

A technology of granules and capsules, which is applied in the field of Ketraling capsules coated and granulated with raw materials and its preparation, which can solve the problems of poor product stability, achieve good stability, facilitate production personnel to distinguish, and shorten the disintegration time limit Effect

Inactive Publication Date: 2019-01-04
广东罗浮山药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The various components are mixed and then granulated, and the reaction between the components will cause the stability of the product to deteriorate; moreover, the contents of the Ketraling capsules currently on the market are all brown to brown-red powders, and no Keteling Capsules Containing Four-color Granules as Contents

Method used

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  • Four-colored granular Keteling capsules and preparation method thereof
  • Four-colored granular Keteling capsules and preparation method thereof
  • Four-colored granular Keteling capsules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A four-color granule Ketering capsule of the present embodiment comprises components A, B, C, and D. The component A is the dry extract of Ficus lobata, and the component B is chlorpheniramine maleate and an appropriate amount of Starch, component C is starch, component D is sodium starch, and the components A, B, C and D are respectively coated and granulated, and then mixed to form capsules.

Embodiment 2

[0025] A four-color granule Ketering capsule of the present embodiment comprises components A, B, C, and D. The component A is the dry extract of Ficus lobata, and the component B is chlorpheniramine maleate and an appropriate amount of Starch, component C is starch, component D is sodium starch, the components A, B, C, and D are respectively coated and granulated, and the coatings of the above components A, B, C, and D are coated with different colors ;

[0026] In the embodiment of the present invention, components A, B, C, and D are coated separately, and may be included in any color, as long as they can be distinguished, which is not limited here.

Embodiment 3

[0028] The preparation method of a four-color granule Keteling capsule in this embodiment, taking the Si-color granule Keteling capsule as an example in this embodiment, includes the following steps:

[0029] (1) granulate the dry extract of Ficus microphylla of component A, dry it to obtain granule 1, and coat granule 1 into white;

[0030] Specifically, in one embodiment, it includes coating the granule 1 into white with a white coating slurry. Preferably, the white coating slurry is composed of the following raw materials: 100 g of white coating powder, 270 g of titanium dioxide, and 80% ethanol 880g.

[0031] (2) Mix component B chlorpheniramine maleate and an appropriate amount of starch, mix well, granulate, and dry to obtain granule 2, and coat granule 2 into yellow; specifically, in one embodiment, it includes using yellow The coating slurry coats the granule 2 into yellow, preferably, the yellow coating slurry is composed of the following raw materials: 100 g of whit...

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Abstract

The invention discloses four-colored granular Keteling capsules. The four-colored granular Keteling capsules comprises a component A, a component B, a component C and a component D, wherein the component A is a ficus microcarpa dry extract; the component B comprises chlorpheniramine maleate and a proper amount of starch; the component C is starch; the component D is sodium starch glycolate; the component A, the component B, the component C and the component D are separately coated and granulated, and are then mixed to obtain the capsules. The invention further discloses a preparation method ofthe four-colored granular Keteling capsules. Aspects of indexes of correlation and the like such as the character, water, disintegration time, thin-layer identification, the content of the ficus microcarpa dry extract and the content of the chlorpheniramine maleate of the four-colored granular Keteling capsules conform to the rule of the pharmacopoeia criterion, wherein the stability of the content of the ficus microcarpa dry extract and the stability of the content of the chlorpheniramine maleate are remarkably higher than the stability of conventional sold products. Due to stable content, short disintegration time, rapid dissolving and rapid absorption, the efficacy is good.

Description

technical field [0001] The invention relates to the technical field of medicine preparation, in particular to a Ketraling capsule in which raw materials are separately coated and granulated and a preparation method thereof. Background technique [0002] Keteling Capsule has antitussive, phlegm-relieving, anti-asthmatic and anti-inflammatory effects. It is used for cough and asthma and chronic bronchitis. It is a routine clinical drug and has the characteristics of good effect and quick onset. It is based on the standard WS of Keterin Capsules recorded in Volume 14 of the "Drug Standards of the Ministry of Health of the People's Republic of China" (Prescriptions of Traditional Chinese Medicine) 3 - Under the item of B-2743-97, it is prepared by "take the dry extract of Ficus microphylla, grind it into fine powder, add chlorpheniramine maleate and appropriate amount of auxiliary materials, mix well, and pack into capsules". The various components are mixed and then granulated...

Claims

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Application Information

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IPC IPC(8): A61K36/60A61K9/50A61K47/02A61P11/06A61P11/10A61P11/14A61K31/4402
CPCA61K9/501A61K31/4402A61K36/60A61P11/06A61P11/10A61P11/14A61K2300/00
Inventor 张小楼黄炜忠廖志钟邓观添
Owner 广东罗浮山药业有限公司
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