Lafutidine coated tablet and preparation method thereof

Abstract

The invention relates to the field of a medicinal preparation, in particular to a lafutidine-containing coated tablet and a preparation method thereof.. The preparation provided by the invention is an oral solid preparation consisting of lafutidine, lactose, microcrystalline cellulose, starch, sodium starch glycolate and magnesium stearate. In order to ensure the main dissolution rate, most of the auxiliaries in the prescription are hydrophilic. In the invention, the technology of the preparation is simple and adopts a few auxiliaries; and the product has stable quality and good dissolution rate, takes an effect quickly and acts for a long time.

Description

technical field [0001] The invention relates to a lafutidine coated tablet and a preparation method thereof, belonging to the field of pharmaceutical preparations. Background technique [0002] Peptic ulcer disease is a common and frequently-occurring disease, and the incidence rate accounts for about 10% of the total population. According to statistics, the hospital's digestive system medication reached 7.25 billion yuan in 1998. At present, there are mainly proton pump inhibitors (omeprazole), H2 receptor antagonists (ranitidine), gastric mucosal protective agents (bismuth), and antacids (aluminum hydroxide) for the treatment of peptic ulcer. Due to its reliable efficacy and low incidence of adverse reactions, H2 receptor antagonists have become the drug of choice for the treatment of hyperacidity, active gastric and duodenal ulcers, and the drug of choice for recurrent gastric and duodenal ulcers. [0003] At present, the most widely used H2 receptor antagonists in Chin...

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Problems solved by technology

[0004] Chinese patent 021359601 discloses a lafutidine injection and its preparation method. Due to the poor stability of the injection, there are problems of patient compliance during use.

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