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Cefetamet pivoxil hydrochloride compound for treating sensitive bacteria infectious diseases

A technology for ceftazidime pivoxil hydrochloride and infectious diseases, applied in the field of ceftazime pivoxil hydrochloride compound, can solve the problems of patient harm, immediate allergic reaction, etc., achieve low polymer content, significant antibacterial activity, strong antibacterial active effect

Inactive Publication Date: 2015-07-22
苗怡文
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, because its basic structure is the same as that of many semi-synthetic β-lactam lactam antibiotics already on the market, ceftazidime hydrochloride will also form high molecular polymers, which will also cause immediate hypersensitivity reactions in clinical use, which is harmful to patients. great

Method used

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  • Cefetamet pivoxil hydrochloride compound for treating sensitive bacteria infectious diseases
  • Cefetamet pivoxil hydrochloride compound for treating sensitive bacteria infectious diseases
  • Cefetamet pivoxil hydrochloride compound for treating sensitive bacteria infectious diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1: Preparation of ceftazidime pivoxil hydrochloride compound

[0028] Get ceftamet pivoxil hydrochloride bulk drug, add in the mixed solvent A of methanol, dimethylformamide whose volume is 6 times of ceftamet pivoxil hydrochloride weight at 15 ℃, the volume ratio of methanol and dimethylformamide is 1:2.5 , to obtain the solution; then on the horizontal direction of the liquid surface of the gained solution, applying a magnetic field intensity is a constant magnetic field of 0.8T, and under the condition of the constant magnetic field, adding volume to the solution is 8 times of the weight of ceftazidime hydrochloride acetone, A mixed solvent of ethyl acetate and diethyl ether, the volume ratio of acetone, ethyl acetate and diethyl ether is 2:3:5; after the dropwise addition is completed, let it stand for 3 hours, filter, wash the filter cake with ethanol, and dry it in vacuum for 2 hours to obtain Described ceftazidime hydrochloride compound.

[0029] Gaine...

Embodiment 2

[0030] Example 2: Preparation of ceftazidime pivoxil hydrochloride compound

[0031] Take ceftamet pivoxil hydrochloride raw material, add in the mixed solvent A of methanol and dimethylformamide whose volume is 7 times of the weight of ceftamet pivoxil hydrochloride at 20°C, the volume ratio of methanol and dimethylformamide is 1:2.5 , to obtain the solution; then on the horizontal direction of the liquid surface of the resulting solution, the applied magnetic field intensity is a constant magnetic field of 1.15T, and under the condition of the constant magnetic field, the solution is dripped with a volume that is 9 times of the weight of ceftazidime hydrochloride acetone, A mixed solvent of ethyl acetate and diethyl ether, the volume ratio of acetone, ethyl acetate and diethyl ether is 2:3:5; after the dropwise addition is completed, let it stand for 4 hours, filter, wash the filter cake with ethanol, and dry it in vacuum for 3 hours to obtain Described ceftazidime hydroch...

Embodiment 3

[0033] Example 3: Preparation of ceftazidime pivoxil hydrochloride compound

[0034] Get ceftamet pivoxil hydrochloride raw material drug, add in the mixed solvent A of methanol, dimethylformamide whose volume is 8 times of ceftamet pivoxil hydrochloride weight at 25 ℃, methanol and dimethylformamide volume ratio are 1:2.5 , to obtain the solution; then on the horizontal direction of the liquid surface of the resulting solution, the applied magnetic field intensity is a constant magnetic field of 1.5T, and under the condition of the constant magnetic field, the solution is dripped with a volume that is 10 times of the weight of ceftazidime hydrochloride acetone, A mixed solvent of ethyl acetate and diethyl ether, the volume ratio of acetone, ethyl acetate and diethyl ether is 2:3:5; after the dropwise addition is completed, let it stand for 5 hours, filter, wash the filter cake with ethanol, and dry it in vacuum for 4 hours to obtain Described ceftazidime hydrochloride compo...

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Abstract

The invention belongs to technical field of medicine, and relates to a cefetamet pivoxil hydrochloride compound for treating sensitive bacteria infectious diseases. An X-ray powder diffraction pattern of the cefetamet pivoxil hydrochloride compound measured by virtue of a Cu-Kalpha ray is shown in a figure 1. The cefetamet pivoxil hydrochloride compound is a novel crystal form compound, and is different from cefetamet pivoxil hydrochloride reported in the prior art. An experiment proves that compared with the prior art, the novel crystal form compound of the cefetamet pivoxil hydrochloride has relatively low high-molecular polymer content and good stability; the increase of the content of the high-molecular polymer is reduced along with prolonging of the storage time; and meanwhile, the compound has relatively significant antibacterial activity on pneumococcus and hemophilus influenza, and has relatively high antibacterial activity on enterococcus and staphylococcus.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a ceftazidime hydrochloride compound for treating infectious diseases of sensitive bacteria. Background technique [0002] Ceftazidime pivoxil hydrochloride is a third-generation broad-spectrum cephalosporin antibiotic. After oral administration, it is rapidly hydrolyzed in the body to cefetamet with antibacterial activity to play a bactericidal effect. Ceftazidime hydrochloride has strong antibacterial activity against Gram-positive bacteria such as Streptococcus (except for Streptococcus faecalis), Pneumococcus, Escherichia coli, Klebsiella, influenza bacilli, and Neisseria gonorrhoeae, especially Serratia spp., indole-positive Proteus spp., Enterobacter spp. and Citrobacter spp. with low sensitivity to cephalosporins had obvious antibacterial activity. Stable against bacterially produced β-lactamases. Ceftazidime hydrochloride is ineffective against Pseudomonas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D501/22C07D501/12A61P31/04
CPCC07D501/22C07D501/12
Inventor 于美莉吴爱丽
Owner 苗怡文
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