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Medicinal composition containing cefetamet pivoxil hydrochloride and mannitol

A technology of ceftamet pivoxil hydrochloride and mannitol, which is applied in the field of medicine, can solve problems such as the dissolution rate of ceftamet pivoxil hydrochloride, and achieve the effects of stability, improvement of dissolution rate, and low production energy consumption

Inactive Publication Date: 2010-06-16
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The object of the present invention is to provide a kind of pharmaceutical composition containing ceftamet pivoxil hydrochloride and mannitol, solve the problems such as ceftazime pivoxil hydrochloride dissolution rate in the ceftazime pivoxil hydrochloride capsule, make it play therapeutic effect more effectively

Method used

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  • Medicinal composition containing cefetamet pivoxil hydrochloride and mannitol
  • Medicinal composition containing cefetamet pivoxil hydrochloride and mannitol

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preparation example Construction

[0061] The present invention provides the preparation method of the composition containing ceftazidime pivoxil hydrochloride and mannitol on the other hand, it comprises steps:

[0062] (a) the ceftazidime pivoxil hydrochloride powder of 100 parts by weight is mixed with the mannitol powder of 10-200 parts by weight;

[0063] (b) Add lubricant and mix evenly, then fill the obtained mixture into empty capsules.

[0064] In a preferred example of the present invention, 0.2-100 parts by weight of a pharmaceutically acceptable additive is also added to the mixture obtained in the step (a), and the additive is selected from pharmaceutically acceptable fillers, pharmaceutically acceptable One or more of surfactants and pharmaceutically acceptable lubricants.

[0065] The preparation method of the composition containing ceftazidime pivoxil hydrochloride and mannitol, it can also take the following steps:

[0066] (a) the ceftazidime pivoxil hydrochloride powder of 100 parts by weig...

Embodiment 1

[0075] The prescription of ceftazime pivoxil hydrochloride capsules 1

[0076] Preparation Content of each component in each capsule (mg)

[0077] Ceftazidime pivoxil hydrochloride 125

[0078] Mannitol 140

[0079] Magnesium Stearate 1

[0080] Preparation method: Pass ceftazidime pivoxil hydrochloride through a 80-mesh sieve, mannitol through a 60-mesh sieve, mix the two evenly, and prepare them into 18-100-mesh granules with a dry granulator; then add magnesium stearate and mix well , filled into No. 1 empty capsules.

Embodiment 2

[0082] The prescription of ceftazidime hydrochloride capsules 2

[0083] Preparation Content of each component in each capsule (mg)

[0084] Ceftazidime pivoxil hydrochloride 250

[0085] Mannitol 110

[0086] Magnesium Stearate 2

[0087] Preparation method: Pass ceftazidime pivoxil hydrochloride through a 80-mesh sieve, mannitol through a 60-mesh sieve, mix the two evenly, then add magnesium stearate, mix well, and fill into No. 0 empty capsules.

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Abstract

The invention relates to a medicinal composition, which contains cefetamet pivoxil hydrochloride and mannitol and is applied orally. .The medicinal composition comprises 100 weight parts of cefetamet pivoxil hydrochloride and 10 to 200 weight parts of mannitol. The medicinal composition of the invention solves the problems that the dissolution of the cefetamet pivoxil hydrochloride in the capsules of the cefetamet pivoxil hydrochloride is low, and the colors of contents are deepened due to wet granulation.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to a pharmaceutical composition containing ceftazidime pivoxil hydrochloride and mannitol. Background technique [0002] Ceftazidime pivoxil hydrochloride is an oral third-generation broad-spectrum cephalosporin antibiotic, clinically used for the treatment of ear, nose and throat infections, lower respiratory tract infections and urinary system infections caused by sensitive bacteria. The current clinical formulations of ceftazidime hydrochloride include tablets, capsules, dry suspensions, dispersible tablets and the like. [0003] Ceftazime pivoxil hydrochloride belongs to the medicine of low solubility, and in aqueous solution, especially under acidic environment, is easy to gel (Kakumanu VK, Arora VK, Bansal AK.Gastro-retentive dosage form for improving bioavailability of Cefpodoxime Proxetil in rats.YakugakuZasshi , 2008, 128 (3): 439-445), resulting in low dissolution rate;...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/546A61K47/10A61P31/04
Inventor 高缘张建军吴莲花高丽琼
Owner CHINA PHARM UNIV
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