43results about How to "Reduce drug content" patented technology

A Chinese medicine in the form of dripping pill for treating cold, fever, sore throat, etc is prepared from scutellaria root, forsythia fruit, isatis leaf and liquorice root.

The invention discloses a method for preparing a location targeting polysaccharide gum carrier material. According to the method, water-based ferroferric oxide is coated with calcium pectinate, a drug carrier is made with a low-methoxyl pectin carrier as a framework material, the ferroferric oxide is modified by a hydrophile group, targeting is achieved through the magnetic ferroferric oxide, drugs are located in the diseased region by means of the external magnetic field and then released, and in this way, drug content in normal tissue is reduced, drug utilization rate is increased, and drug toxicity is reduced; by taking the low-methoxyl pectin carrier as the framework material, toxicity is avoided, safety is achieved, biocompatibility and biodegradability are high, the therapeutic index of drugs can be increased, drug toxicity can be reduced, and the side effects of drugs can be reduced.

The present invention relates to cyclodextrin inclusion compound of desonide and its preparation process. The cyclodextrin inclusion compound of desonide has molecule ratio between desonide and cyclodextrin of 0.1-2. It is prepared through adding the alcohol solution of desonide into the water solution of cyclodextrin to include. Compared with common desonide preparation, the cyclodextrin included desonide preparation has obviously raised stability.

The invention relates to the technical field of pharmaceutical preparations, in particular to a solid self-microemulsion containing abiraterone acetate. The abiraterone acetate solid self-microemulsion is prepared from the following components in percentage by mass: 0.25%-1.5% of abiraterone acetate, 5%-10% of an oil phase, 25%-30% of a surfactant, 12.5%-15% of a cosurfactant and 45%-55% of a solid carrier. According to the invention, solidification of the liquid medicine is realized, prescription screening and optimization are carried out through a single factor test to obtain the self-microemulsion which is free of preservatives, easy to store, easy to transport and more stable, and the preparation method is simple, controllable and good in repeatability. Particles in the transmission electron microscope image display period of the emulsion of the abiraterone acetate solid self-microemulsion are regularly spherical and are uniformly distributed, and the particle size is less than 100nm.

A dripping pill of mint oil for treating chronic lithocholeoystitis, chronic cholecystitis, cholelithiasis, etc is prepared from mint oil, polyethandiol 2000-20000, beta-cycoldextrin and carboxymethyl starch sodium.

The invention discloses a compound docetaxel ester microsphere injection and a preparation method thereof, belonging to the technical field of medicines. The compound docetaxel ester microsphere injection is characterized by being prepared from the following raw materials in weight parts: 0.5 to 5 parts of docetaxel, 30-150 parts of Brucea javanica oil, 30-150 parts of middle-chain triglyceride, 10-30 parts of lecithin, 10-60 parts of polyethylene glycol surface active agents, 20-35 parts of glycerine and 700-950 parts of sterilized water for injection. The compound docetaxel ester microsphere injection of the invention is oil in water type microsphere preparation. The docetaxel as a main drug is coated in the Brucea javanica and middle-chain triglyceride compound oil phase of the oil in water type microsphere. The microsphere has a smaller grain diameter (which is lower than 100nm), and the preparation has better stability. The compound oil phase compositions play a cooperative anticancer role, and reduce the stimulation reaction of the injection and the side reactions such as hemolysis, allergy and the like. The invention has targeting function and increases the medicine effect.

The invention discloses a bee glue drop pill for treating dentalgia, which is a medicinal composition with the functions of relieving pain, haemostasis and the auxiliary treatment for periodontitis. The pharmaceutical composition is prepared from bee glue as the raw material through the conventional drop pill preparing process.

The present invention relates to a kind of medicine composition, tranquilizign wild jujube seed dripping pill, used in treating insomnia, amnesia, dizziness, headache, etc. caused by heart, liver and blood deficiency and neurosism. The present invention has high bioavailability, fast medicine release, fast acting, high effective content, taking convenience and low cost, and its production process has no pollution. The tranquilizign wild jujube seed dripping pill is prepared with three kinds of Chinese medicinal materials of wild jujube seed, red sage and schisandra and medicine carrier as matrix.

The invention relates to a drug for treating adiposis and hepatopatic diseases and particularly relates to a drug compound oral pharmaceutical formulation adopting L-carnitine (or L-carnitine salts) as drug active ingredient and having the effects of reducing weight and inhibiting hepatopatic diseases. The drug aims to supplement the deficiency of the prior art and provide a sustained-release L-carnitine dropping pill formulation. The sustained-release L-carnitine dropping pill is prepared by adding stabilize Vitamin E to the ingredients accepted in the prior art to guarantee no occurrence of an obvious change related to the substance content for the drug during the effective storage period and has the advantages of full release, controllable release time and high bioavailability simultaneously. The sustained-release L-carnitine dropping pill is suitable for clinical and family use.

The invention relates to a support device for supporting lumen medical instruments. The support device for supporting the lumen medical instruments includes a shielding structure, the shielding structure includes a plurality of baffles, the plurality of baffles are arranged in a radical mode, and the diameters of the circumscribed circles of the baffles are equal to the inner diameters of the lumen medical instruments. When the support device for supporting the lumen medical instruments is used for supporting a stent and spraying coating, the stent is sleeved on the shielding structure, the outer side surface of each baffle abuts against the inner wall of the stent, the contact area of the stent and the support device for supporting the lumen medical instruments is greatly reduced, and thesituation of film or even coating peeling off is avoided advantageously; and moreover, the plurality of baffles can effectively shield dripping spray liquid, and thus the drug content on the inner wall of the stent can be decreased.

The invention relates to a drug composition containing granisetron. The drug composition comprises a sodium polyacrylate pressure-sensitive adhesive (A), a polyacrylic resin (B), a penetration enhancer (C) and granisetron (D), wherein the sodium polyacrylate pressure-sensitive adhesive (A) is a (methyl) acrylate copolymer containing (methyl) acrylamide or N, N-substituted monomer thereof; the polyacrylic resin (B) is an Eudragit polyacrylic resin; and the penetration enhancer (C) is selected from isopropyl myristate, azone, glyceryl triacetate and 1, 2-propylene glycol as well a a mixture thereof. A granisetron transdermal patch containing the drug composition obtains satisfactory technical effects on mechanical property, skin irritation and the like; more importantly, the transdermal patch obtains considerable transdermal flux when the excellent performances are guaranteed.

The present invention relates to a kind of medicine composition with functions of nourishing Yin and promoting secretion of body fluid for treating emaciation with yellowish complexion, waist and knees soreness, poor appetite, dizziness, heart palpitation, etc. The ginseng-ophiopogon root dripping pill has high bioavailability, fast medicine release, fast acting, high effective component content, convenience taking and low cost, and its production has no pollution. The ginseng-ophiopogon root dripping pill is prepared with red ginseng, root of straight ladybell, ophiopogon root, sealwort, Chinese yam and wolfberry fruit as Chinese medicine and medicine carrier as matrix.

The invention discloses a Huzhu Bamei pig feed with an antibacterial effect and a preparation method thereof. The Huzhu Bamei pig feed mainly consists of auxiliary materials, an antibacterial ingredient and active ingredients, wherein the antibacterial ingredient is terramycin; the active ingredients comprise the following components in parts by weight: 5-10 parts of cis-butenedioic acid, 2-20 parts of peptide, 10-30 parts of radix angelica sinensis, 3-20 parts of radix astragali, 8-40 parts of poria cocos, 5-30 parts of radix bupleuri and 1-3 parts of vitamin complex; the weight ratio of theauxiliary materials, the antibacterial ingredient and the active ingredients is 100 to 1 to (1-1.5). The preparation method is as follows: puffing the auxiliary materials, then mixing the puffed auxiliary materials with the antibacterial ingredient and the active ingredients, and granulating the mixture, thereby obtaining the Huzhu Bamei pig feed. The Huzhu Bamei pig feed disclosed by the invention is capable of obviously reducing toxin residues in Huzhu Bamei pigs and promoting weight increase of pigs and is less in scale of feeding and good in palatability. By virtue of puffing the auxiliarymaterials, the adsorption capability of the auxiliary materials is improved, and furthermore the metabolization speed of antibiotics in the Huzhu Bamei pigs is improved; the Huzhu Bamei pig feed is highly targeted, is only applicable to feeding Huzhu Bamei pigs, can not achieve obvious effects on other varieties of pigs, and is suitable for wide popularization.

The invention relates to composition for treating jaundice of salix integra. The composition for treating jaundice of the salix integra is prepared by compounding traditional Chinese medicine components and bismerthiazol. Effective components are extracted from traditional Chinese medicine components and used for treating jaundice of the salix integra, the treatment effect is good, the composition can effectively prevent spore germination, and meanwhile, the medicine can damage enzyme in pathogenic cells, so that pathogenic cells cannot metabolize normally and die; additionally, the composition has good disease prevention capacity if sprayed before the salix integra is sick, medicine resistance of pathogenic bacteria cannot be influenced due to the fact that the traditional Chinese medicine components are used for resisting diseases, normal growth of the salix integra cannot be influenced, damage to environment cannot be caused, and the yield of the salix integra is increased.

The invention discloses a Luxi cattle feed high in nutritive value. The Luxi cattle feed mainly consists of auxiliary materials, a bacteriostasis component and active components, wherein the bacteriostasis component is vibramycin; the active components comprise the following components in parts by weight of 5-10 parts of tartaric acid, 2-20 parts of lysine, 10-30 parts of shrubalthea flowers, 3-20parts of frankincense, 8-40 parts of plaster, 5-30 parts of plantain seeds and 1-3 parts of composite vitamins; and the weight ratio of the auxiliary materials to the bacteriostasis component to theactive components is 100 to 3 to (3-5.5). A preparation method of the Luxi cattle feed comprises the following steps of puffing the auxiliary materials, then mixing the puffed auxiliary materials withthe bacteriostasis component and the active components, and performing granulation. According to the Luxi cattle feed disclosed by the invention, the residues of the vibramycin in Luxi cattle bodiescan be remarkably reduced, the weight increment of the cattle is facilitated, the feed quantity is low, and the Luxi cattle feed is good in palatability; the auxiliary materials are puffed, so that the adsorption capacity of the auxiliary materials is increased, and the metabolism velocity of antibiotics in the Luxi cattle bodies is further increased; and the Luxi cattle feed is high in pertinence, is only suitable for raising Luxi cattle, does not have remarkable effects on other varieties of cattle, and is suitable for extensive popularization and application.

The disclosure provides a lyophilized preparation of prostaglandin E1 methyl ester for injection and production and use thereof. The lyophilized preparation comprises the following components by weight: 0.1-10 parts of prostaglandin E1 methyl ester, 500-4000 parts of an oil for injection, 500-2000 parts of an emulsifier, 0-10 parts of a co-emulsifier, 5000-50000 parts of a lyoprotectant, and 200-1500 parts of glycerin. The prostaglandin E1 methyl ester lyophilized agent of the disclosure has less blood vessel irritation, good drug stability, and superior drug activity and therapeutic effect than similar prostaglandin E1 products.

A Chinese medicine in the form of dripping pill for treating palpitation, dizziness, headache, insomnia, etc is prepared from the leaf, stem and flower of notoginseng, etc.