Levo carnitine dropping pill and preparation thereof

A technology of L-carnitine and L-carnitine tartrate, which is applied in the directions of pill delivery, pharmaceutical formulations, and medical preparations containing active ingredients, can solve problems such as the lack of public technical materials for L-carnitine dropping pills, and avoid liver and intestine problems. First-pass effect, improved bioavailability, simple equipment effect

Active Publication Date: 2005-10-12
JIANGXI JIMINKEXIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to the investigation, there is no public technical information or report about L-carnitine dripping pills

Method used

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  • Levo carnitine dropping pill and preparation thereof
  • Levo carnitine dropping pill and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0041] Now with several groups of specific examples, the preparation method of L-carnitine dripping pills of the present invention will be further described.

[0042] [The first group: L-carnitine dripping pills prepared with L-carnitine as the active ingredient]

[0043] 1. The embodiment using a single matrix

[0044] 1.1 English name of L-carnitine - L-carnitine, Chinese translation - Kang Liting;

[0045] Alias ​​- L-carnitine, vitamin B T ;

[0046] Chemical name - the chemical name is L-β-hydroxy-γ-methylammonium butyric acid;

[0047] 1.2 Substrate - polyethylene glycol (2000～20000) , polyoxyl 40 stearate, beta cyclodextrin, poloxamer, sodium carboxymethyl starch, sodium lauryl sulfate, stearic acid, sodium stearate, glycerin gelatin, shellac;

[0048] 1.3 Ratio - in g or kg, L-carnitine: matrix = 1:1 ~ 1:5;

[0049] 1.4 According to the steps of [Preparation Method] 4-7, L-carnitine dripping pills of different specifications can be prepared.

[0050] [test resul...

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Abstract

The invention relates to levo carnitine dropping pill for treating adiposis, hepatic disease, which has a high bioavailability, a fast medicine release, a small toxic and deleterious effect, a low utilized cost, and no pollution. The levo carnitine dropping pill takes the levo carnitine or the tartrate and fumarate as medicine active component and can be prepared together with the medicinal carrier as substrate.

Description

technical field [0001] The invention relates to a medicine for treating obesity and liver disease, in particular to an oral preparation of a pharmaceutical composition which takes L-carnitine (or its salts) as an active pharmaceutical ingredient and has the functions of reducing weight and inhibiting liver disease. Background technique [0002] At present, with the improvement of people's living standards in our country, the incidence of obesity is gradually increasing. In 1982, 1989 and 1992, the incidence of overweight and obesity in cities across the country was 9.7%, 12.0% and 14.9%, showing a gradual increase. rising trend. Obesity itself and its closely concurrent hypertension, dyslipidemia, type II diabetes, coronary heart disease and some tumors have seriously affected people's quality of life and shortened their lifespan. It is currently recognized that a 5% to 10% reduction in body weight can significantly improve the risk factors associated with obesity mentioned...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/205A61P1/16A61P3/04
Inventor 曲韵智
Owner JIANGXI JIMINKEXIN PHARMA
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