Levorotation carnitine sustained-release dropping pill and preparation method thereof

Abstract

The invention relates to a drug for treating adiposis and hepatopatic diseases and particularly relates to a drug compound oral pharmaceutical formulation adopting L-carnitine (or L-carnitine salts) as drug active ingredient and having the effects of reducing weight and inhibiting hepatopatic diseases. The drug aims to supplement the deficiency of the prior art and provide a sustained-release L-carnitine dropping pill formulation. The sustained-release L-carnitine dropping pill is prepared by adding stabilize Vitamin E to the ingredients accepted in the prior art to guarantee no occurrence of an obvious change related to the substance content for the drug during the effective storage period and has the advantages of full release, controllable release time and high bioavailability simultaneously. The sustained-release L-carnitine dropping pill is suitable for clinical and family use.

Description

technical field [0001] The invention relates to a medicine for treating obesity and liver disease, in particular to a slow-release oral preparation of L-carnitine (or its salts) which is used as an active pharmaceutical ingredient and has the functions of reducing weight and inhibiting liver disease. Background technique [0002] At present, with the improvement of people's living standards in our country, the incidence of obesity is gradually increasing. In 1982, 1989 and 1992, the incidence of overweight and obesity in cities across the country was 9.7%, 12.0% and 14.9%, showing a gradual increase. rising trend. Obesity itself and its closely concurrent hypertension, dyslipidemia, type II diabetes, coronary heart disease and some tumors have seriously affected people's quality of life and shortened their lifespan. It is currently recognized that a 5% to 10% reduction in body weight can significantly improve the risk factors associated with obesity mentioned above, and sho...

AI Technical Summary

Problems solved by technology

[0010] Due to reasons such as preparation technology, most oral preparations of drugs have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect, and low bioavailability, which affect the efficacy of the drug and directly affect the therapeutic effect

At the same time, conventional tablets or capsules, due to their complex production process and equipment, and high production costs, make the cost of taking them higher for patients.

Furthermore, tablets and capsules will generate relatively large dust during production, and the pollution to the environment is also relatively serious.

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