Levorotation carnitine sustained-release dropping pill and preparation method thereof

A technology of L-carnitine and slow-release dripping pills, which is applied in the direction of pharmaceutical formulas, medical preparations with no active ingredients, and medical preparations containing active ingredients, etc. It can solve the problems of low dissolution rate, complex production process, equipment, and patient costs. Advanced problems, to achieve the effects of accelerated dissolution and absorption, improved bioavailability, and fewer times of taking medicine

Inactive Publication Date: 2008-09-24
北京博智绿洲医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Due to reasons such as preparation technology, most oral preparations of drugs have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect, and low bioavailability, which affect the efficacy of the drug and directly affect the therapeutic effect
At the same time, conventional tablets or capsules, due to their complex production process and equipment, and high production costs, make the cost of taking them higher for patients.
Furthermore, tablets and capsules will generate relatively large dust during production, and the pollution to the environment is also relatively serious.

Method used

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  • Levorotation carnitine sustained-release dropping pill and preparation method thereof

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Embodiment Construction

[0040] Now with several groups of specific examples, the preparation method of the L-carnitine sustained-release dropping pills of the present invention will be further described.

[0041] First group:

[0042] Based on the total weight of 100g, weigh 40% of the matrix PEG4000, 10% of PEG6000, 10% of PEG10000, 11% of stearic acid, 17% of glyceryl monostearate, 2% of vitamin E as a stabilizer, and 10% of raw material L-carnitine; Heat the matrix in a heating container and stir it to melt, add the corresponding proportion of L-carnitine, stir well, then add the stabilizer vitamin E and stir evenly, then drop the molten or mixed liquid medicine under the condition of heat preservation Put it into a condensation column filled with simethicone oil, where the temperature when heating and melting is 55°C, the temperature of the upper part of the condensate is 20°C, and the temperature of the bottom is -4°C; take it out after forming.

[0043] The obtained product has a cumulative rele...

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Abstract

The invention relates to a drug for treating adiposis and hepatopatic diseases and particularly relates to a drug compound oral pharmaceutical formulation adopting L-carnitine (or L-carnitine salts) as drug active ingredient and having the effects of reducing weight and inhibiting hepatopatic diseases. The drug aims to supplement the deficiency of the prior art and provide a sustained-release L-carnitine dropping pill formulation. The sustained-release L-carnitine dropping pill is prepared by adding stabilize Vitamin E to the ingredients accepted in the prior art to guarantee no occurrence of an obvious change related to the substance content for the drug during the effective storage period and has the advantages of full release, controllable release time and high bioavailability simultaneously. The sustained-release L-carnitine dropping pill is suitable for clinical and family use.

Description

technical field [0001] The invention relates to a medicine for treating obesity and liver disease, in particular to a slow-release oral preparation of L-carnitine (or its salts) which is used as an active pharmaceutical ingredient and has the functions of reducing weight and inhibiting liver disease. Background technique [0002] At present, with the improvement of people's living standards in our country, the incidence of obesity is gradually increasing. In 1982, 1989 and 1992, the incidence of overweight and obesity in cities across the country was 9.7%, 12.0% and 14.9%, showing a gradual increase. rising trend. Obesity itself and its closely concurrent hypertension, dyslipidemia, type II diabetes, coronary heart disease and some tumors have seriously affected people's quality of life and shortened their lifespan. It is currently recognized that a 5% to 10% reduction in body weight can significantly improve the risk factors associated with obesity mentioned above, and sho...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/205A61K47/34A61P3/04A61P1/16A61K47/10A61K47/14
Inventor 曲韵智
Owner 北京博智绿洲医药科技有限公司
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