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Oral drop pill in use for clearing away heat and toxic material and preparing method

A technology of clearing away heat and detoxification and dripping pills, which is applied in the direction of pill delivery, medical preparations containing active ingredients, and medical raw materials derived from angiosperm submenus, which can solve the problem of first-pass bioavailability of the liver and intestines, which is not conducive to improving the ability of patients to seek medical treatment , Workers' physical hazards and other issues, to achieve the effect of benefiting labor protection, improving bioavailability and environmental protection

Inactive Publication Date: 2007-06-27
北京博智绿洲医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Due to the preparation technology and other reasons, the oral preparations of most drugs, especially the oral preparations of traditional Chinese medicine, have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking. , thus affecting the efficacy of the drug and directly affecting the therapeutic effect
The drug content of granules is also low, and it is inconvenient to take
[0008] In addition, conventional oral dosage forms, such as tablets, capsules, granules (infusions), etc., due to the granulation process in the preparation process, will generate relatively large dust pollution, which will cause health problems to the staff to a certain extent. harm, and also cause some pollution to the environment
Furthermore, the production process of conventional oral preparations is complicated and the production cost is high, so that the cost of medication for patients is also increased, which is not conducive to improving the ability of patients to seek medical treatment, and is also not conducive to improving the overall health level of society.

Method used

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Examples

Experimental program
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Effect test

Embodiment Construction

[0029] The preparation method of Qingreling dripping pills of the present invention will be further described with several groups of specific examples.

[0030] Group 1: Tests with a single matrix

[0031] 1. Preparation of medicinal extract: take g or kg as the unit, and take 5 parts of Scutellaria baicalensis, 5 parts of forsythia, 5 parts of Folium Folium, 1 part of licorice, and the above four flavors, add water to decoct twice, 1.5 hours each time, combine the decoction, filter, concentrate the filtrate to a relative density of 1.08, let it cool to room temperature, add ethanol to make the alcohol content 58% to 60%, let it stand for 24 hours, filter, and concentrate the filtrate to a relative density It can be obtained as a thick paste of 1.3-1.35; or it can be dried below 80°C and crushed into dry powder to obtain it;

[0032] 2. Substrate: polyethylene glycol (2000、4000、6000、8000、10000、20000) , polyoxyl 40 stearate, beta cyclodextrin, poloxamer, sodium carboxymethyl ...

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Abstract

A Chinese medicine in the form of dripping pill for treating cold, fever, sore throat, etc is prepared from scutellaria root, forsythia fruit, isatis leaf and liquorice root.

Description

technical field [0001] The present invention relates to a kind of medicine composition that has heat-clearing and detoxifying effect, and is used for the treatment of cold, fever, sore throat, etc. The pharmaceutical composition is an oral drop pill preparation. Background technique [0002] According to the ministerial drug standard WS 3 -Qingreling granule prepared by the preparation method given in B-2996-98 is a kind of oral granule with heat-clearing and detoxifying effect, which is used for the treatment of cold, fever, sore throat and other diseases. It has been clinically verified that the curative effect is exact , is a commonly used drug for clinical and family treatment of such conditions. [0003] The following is the drug standard WS 3 - Formula and process and brief description given in B-2996-98: [0004] Prescription: Scutellaria baicalensis 250g, forsythia 250g, Daqingye 250g, licorice 50g [0005] Preparation method: decoct the above four flavors with ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/634A61K36/539A61K36/484A61K36/315A61K36/19A61P31/00A61P11/04
Inventor 曲韵智
Owner 北京博智绿洲医药科技有限公司
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