39 results about "Drugs toxicity" patented technology

The invention provides nucleic acids, peptides, and antibodies for use in applications including diagnosis and therapy. The peptides target lung cancer and were identified by phage display. Targeting phage PC5-2 and synthetic peptide SP5-2 were both able to recognize human pulmonary tumor specimens from lung cancer patients. In SCID mice bearing NSCLC xenografts, the targeting phage was able to target tumor masses specifically. When the peptide was coupled to liposomes containing the anti-cancer drugs vinorelbine or doxorubicin, the efficacy of these drugs against human lung cancer xenografts was improved, the survival rate increased, and the drug toxicity was reduced.

A microfabricated multi-tissue system for in vitro drug toxicity testing having a plurality of layers, each of which is formed of decellularized tissue extracellular matrix (ECM) including parenchymal cells and non-parenchymal cells attached thereto. Also disclosed is a method for producing a decellularized ECM paste, and methods for producing an ECM construct and a porous 3-D scaffold from the decellularized ECM paste.

The invention relates to an application method of a combined reagent in copper and sulphur separation of ore beneficiation of covellite predominantly copper sulfide ore. The invention comprises the following steps: size mixing with lime after grinding of raw ores to enable the pH value of raw ore pulps to be 7 to 12, utilizing loatation an O - isopropyl - N - sulfur ethyl carbamate and sodium butyl xanthogenate to obtain an accumulated opper and sulphur mixing concentrate; grinding the accumulated copper and sulphur mixing concentrate to reach the required grinding fineness in the copper and sulphur separation, and directly putting the combined reagent with the lime and an copper collector into the copper and sulphur separation work to activate easy oxidized copper blue minerals and restrain iron pyrites to the effective separation of the copper and the sulphur. Utilizing the application method of the combined reagent in copper and sulphur separation of ore beneficiation of covellite predominantly copper sulfide ore can achieve the effective separation effect of the copper and sulphur, and sodium sulphide and sodium humate can effectively restrain pyrite; in a same separation effect, the using amount of the combined reagent only amounts to 40% to 50% of the lime and other inhabitors; and drug toxicity is small and is environmentally friendly.

The invention discloses a triazole compound. The triazole compound has excellent water solubility. The triazole compound is obtained by introduction of a novel functional group to high efficiency and wide spectrum antifungal compound voriconazole and fluconazole drugs found in the existing clinical application and novel drug development so that the triazole compound greatly improves voriconazole and fluconazole water solubility and reduces drug toxicity.

The invention discloses a movable processing method and a device. The movable processing method and device are aimed at dispersity and complexity generated by oily sludge, and drug toxicity caused by refining process, and conduct innocent treatment upon self heating value of the oily sludge. A combination processing method of thermo-chemistry refining and pyrolysis burning is adopted to conduct intelligent combination aimed at geographical features and mechanism of production of the oily sludge. A total craft process includes: oily sludge earlier stage processing -> pyrolysis burning -> desorption -> filtering -> cyclic utilization -> discharging, wherein each module not only has an independent function, but also has a combination function, and can achieve functions such as pyrolysis burning, decomposition absorption, crude oil recovery, sludge elutriation, sludge drying and sludge solidification. The oily sludge after processed does not contain petroleum and other injurious ingredient and accords to environment-friendly discharging requirement, and the system can continuously operate for 24 hours, conducts crude oil recovery for sludge with high oil, and achieves the aims of reduction, harmlessness and reclamation of treatment and disposal of hazardous wastes.

The invention discloses a coronary artery dilating catheter carrying ligustrazine nanoparticles. The coronary artery dilating catheter is characterized by comprising a sharp end, a guide wire channel, a far end part of the catheter, a sacculus of which the outer surface carries the ligustrazine nanoparticles, a near end part of the catheter, a side hole and a replenishing device, wherein the sharp end is connected to the guide wire channel and is communicated with the side hole; one end of the sacculus is fixed to the guide wire channel; the other end of the sacculus is connected to the far end part of the catheter; the side hole is located in the far end part of the catheter outside the sacculus; the far end part of the catheter is connected to the near end part of the catheter; the near end part of the catheter is connected to the replenishing device; the guide wire channel, the far end part of the catheter and the sacculus are not communicated. During dilation, ligustrazine nanoparticle medicines on the coronary artery dilating catheter can directly contact the inner coronary artery plaque, and the resistance is reduced; meanwhile, compared with dilating catheters of other medicines, the coronary artery dilating catheter carrying the ligustrazine nanoparticles has the advantages that the drug toxicity of the ligustrazine nanoparticle medicines is smaller, and the price is low.

The present invention discloses a high-value utilization method of lignin in black liquor. The pH value of the black liquor is regulated step by step by using dilute acid such as sulfuric acid and thelike, so that lignin is graded and precipitated; and the obtained lignin is purified by using an ethanol/water mixed solution, so that the obtained lignin has high purity and uniform molecular weightdistribution. Through the step-by-step precipitation, the lignin can be effectively classified based on the molecular size, and further development and utilization of lignin samples are facilitated.Hydrophobic modification treatment is carried out on the lignin sample through an acetylation reaction, and then dissolution performance of lignin in an organic solvent-water mixed system can be changed, so that the lignin can be used as a raw material to prepare novel materials such as drug release controlling agents, nano adsorption materials and the like, and thus the application range of lignin is expanded. The method provided by the invention has the advantages of low cost investment, low drug toxicity, less required equipment, simple operation method and easy realization of large-scale production and application.

The invention discloses a quick-acting drug abstinence de-addiction pure Chinese medicinal preparation and a preparation method thereof. The quick-acting drug abstinence de-addiction pure Chinese medicinal preparation consists of two parts, namely a drug abstinence, toxin expulsion and detoxication Chinese medicinal preparation A and a drug abstinence, body resistance strengthening and mind tranquilizing Chinese medicinal preparation B, and belongs to the field of traditional Chinese medicines. The quick-acting drug abstinence de-addiction pure Chinese medicinal preparation is preferably prepared by refining raw materials such as cordyceps sinensis, American ginseng, astragalus, Chinese angelica, Japanese milkwort herb, liquoric root, baical skullcap root, golden thread, yanhusuo, medicinal evodia fruit, Chinese date, honeysuckle flower, spina date seed, thinleaf milkwort root-bark and the like. The quick-acting drug abstinence de-addiction pure Chinese medicinal preparation has the effects of supporting healthy energy, expelling drug toxicity, abstaining drugs, promoting flow of Qi and blood circulation, dispersing cold to ease pain, calming the heart, tranquilizing the mind and the like. The preparation has reasonable compatibility of the medicines, has a simple preparation process, is convenient to take, has quick response and has no adverse side effect or addiction, the patient is quickly recovered and does not need injection, transfusion or care, and the preparation is one of the most effective medicines for drug abstinence at present.

The invention discloses lotus rhizome plantation high-efficiency fertilizer. The lotus rhizome plantation high-efficiency fertilizer comprises, by weight, 10-20 parts of plant straws, 15-20 parts of turf, 1-5 parts of urea, 4-8 parts of bean cake, 8-12 parts of Chinese medical stone, 9-13 parts of boric acid, 5-7 parts of potassium carbonate, 10-15 parts of itaconic acid, 3-5 parts of trace elements and 1-3 parts of a growth conditioning agent. The lotus rhizome plantation high-efficiency fertilizer greatly improves a lotus rhizome yield. The lotus rhizome treated by the lotus rhizome plantation high-efficiency fertilizer has good quality and a long fresh-keeping period, has disease prevention, bacteriostasis, stress resistance and no drug toxicity, is rich in boron and potassium, satisfies crop growth and development requirements and improves economic benefits.

The invention relates to a quality control method for a drug microtox assay system, wherein the quality control method comprises the following steps: (1) reference substance solution preparation: taking ZnSO4.7H2O, dissolving, preparing ZnSO4.7H2O solutions with the concentrations respectively of 5.0 mg.L<-1>, 20.0 mg.L<-1>, 40.0 mg.L<-1>, 80.0 mg.L<-1>, 100.0 mg.L<-1> and the like, and then respectively mixing with a 20% sodium chloride solution with the volume ratio of 17:3, to obtain a series of solutions as tested solutions of points of a standard curve; (2) test bacterial liquid preparation: taking vibrio fischeri, restoring, to obtain a test bacterial liquid, and determining the luminous intensity; and (3) detection: taking the reference substance solutions of the step (1), adding the test bacterial liquid, respectively determining the luminous intensities, drawing the standard curve, and carrying out accompanying quality control of a sample solution in the process of detection. The quality control method used for the drug microtox assay system and established by the method has the advantages of high sensitivity, high precision, high accuracy and good stability, can be used for detection of drug toxicity, and has good application prospect.

The invention discloses a derivative of pyridine and (4,3-d) pyrimidine-1(2H)-base phenyl acetamide and an application thereof. The derivative has good pharmaceutical activity, can greatly prolong the half-life periods of drugs, prolongs the retention time of drugs in the human body, and meanwhile increases the drug concentration in the blood. Therefore, a better curative effect is achieved. As the half-life periods of drugs are greatly prolonged, the drugs can keep activity concentration for a longer time in the blood. Under the cure condition with dose limiting, the curative effect can be kept and the recommended dosage of drugs can be reduced at the same time, therefore the bad metabolism of drugs is eliminated, the drug toxicity is reduced, and the toxic and side effects in the drug using process are small.

The invention discloses a Chinese herbal medicine feed additive for Dongchuan pigs and a Dongchuan pig feeding method. The Chinese herbal medicine feed additive is prepared from the following components in percentage by weight: 14-16% of medicated leaven, 8-10% of malt, 8-10% of garlic, 8-12% of astragalus membranaceus, 8-10% of codonopsis pilosula, 10-12% of polygonum multiflorum, 14-16% of angelica sinensis and 15-20% of liquorice. The Chinese herbal medicine feed additive is simple to prepare and good in effect. By using Chinese herbal medicine additives in the feed, the residuals of additives such as antibiotics and chemical synthetic drugs in pork can be decreased, the carcass character and the pork quality can be remarkably improved, the carcass meat factor can be improved, the drug residue can be decreased, the chemical drug toxicity can be decreased and guarantee can be provided to the food safety of people.

The invention discloses a heat-clearing detoxifying agent and a preparation method thereof. A specific extraction method is employed to extract effective components from mung beans and licorice in the raw materials, then natural plant ingredients are added to conduct pretreatment on part of the raw materials, the pretreated raw materials can strengthen the effects of the Chinese medicinal extracts and natural plant ingredients, the prepared heat-clearing detoxifying agent not only has the efficacy of removing mould and expelling toxin, harmonizing drug properties, easing drug toxicity and virulence, and protecting animal health, but also has certain therapeutic action on bronchitis.

The invention discloses a double-drug-loading self-healing hydrogel system and a preparation method thereof. The preparation method comprises the steps of adopting oxidized pullulan, epsilon-polylysine and low molecular weight polyethyleneimine as raw materials, adding two anti-cancer drugs such as cis-platinum and doxorubicin hydrochloride while preparing a hydrogel, and generating dynamic imine linkage through Schiff base reaction and crosslinking to prepare the double-drug-loadingself-healinghydrogel system. The preparation method provided by the invention is simple to operate, and short in preparation period; the prepared hydrogel system has biocompatibility, syringeability and self-healing property, and is loaded with two drugs at the same time, so that combined chemotherapy can be carried out on malignant tumors through parenteral administration around the tumor, the drugs play tosynergistic effect, a curative effect is enhanced, and the drug toxicity and the drug resistance are reduced.

The invention discloses nutritive honey syrup for alleviating drug toxicity and a preparation method of the nutritive honey syrup. The efficacies of honey for removing toxicity and nursing the intestine and the stomach are fully exerted, and through auxiliary materials, ingredients and a preparation method, the purposes of alleviating the drug toxicity and reducing the toxic and side effects of drugs can be realized after people eat larger dosage of finished products for three treatment courses. The nutritive honey syrup for alleviating the drug toxicity disclosed by the invention comprises raw materials, auxiliary materials and ingredients, wherein the raw materials comprise the following component in parts by weight: 35-40 parts of honey; the auxiliary materials comprise the following components in parts by weight: 15-20 parts of anthocyanidin fruits and 10-15 parts of anthocyanidin leaves; and the ingredients comprise the following components in parts by weight: 5-10 parts of red jujubes, 5-10 parts of haws, 5-10 parts of cassia twigs, 5-10 parts of Chinese wolfberry fruits, 5-10 parts of lemons, 5-10 parts of licorice roots and 5 parts of fresh ginger.

A novel method useful in drug screening. The method is useful for testing effects of substances on the mitochondria, notably toxic or beneficial effects of drug substances or candidate drug substances. The method is based on measurement in live human mitochondria ex vivo, but in a setting as near the in vivo situation as possible. The method is also useful for testing substances impact on the mitochondrial respiration. The method can be used to i) screening and selection of early or late stage drug candidates in cells derived from blood from healthy individuals or in so-called buffy coat, which is a concentrated solution of platelets and white blood cells, ii) testing a patient's sensitivity to a known mitochondrial toxicant, iii) analysing mitochondrial drug toxicity in clinical trials, and/or iv) analysing beneficial effects of drugs intended to improve mitochondrial function

The invention provides a combined medicine. The combined medicine consists of artemisinin which serves as a first active ingredient, hydroxychloroquine sulfate which serves as a second active ingredient and optional pharmaceutically acceptable adjuvants. The combined medicine can be used for treating malaria more effectively, and the combined medicine can relieve drug toxicity and delay the generation of drug resistance.

The present invention relates to a high-efficiency traditional Chinese medicine anticancer product and its preparation method, use method and application. The effective anti-cancer ingredients contained in the present invention do not contain or less contain ineffective ingredients that do not have anti-cancer functions and have potential drug toxicity; Combined with the spray drying process, it is applied to the production of traditional Chinese medicine anticancer products, and combined with the optimized use method, the solubility, the absorption rate of the human body, the content of active ingredients and the medicinal efficacy of the product are improved, and the toxicity of the product to the human body is reduced. , has a wide range of applications.

The invention belongs to the technical fields of RAFT polymerization, PEG-A monomer grafting and drug toxicity testing, and relates to a method for improving the water solubility of 7,8-dihydroxyflavanone based on a RAFT polymerization method. The method comprises the following steps: first performing chlorination reaction on a RAFT reagent, then grafting the RFAT reagent to the 7,8-dihydroxyflavanone, and finally performing RAFT polymerization reaction to graft PEG-A to the 7,8-dihydroxyflavanone. A process is simple and convenient to operate, the improvement effect on the water solubility of the 7,8-dihydroxyflavanone is obvious, the molecular weight is easy to control, the cost and the toxicity are low, and the polymerization degree can be accurately controlled by RAFT polymerization so as to synthesize 7,8-dihydroxyflavanone with different molecular weights and different polymerization degrees.