9 results about "Multivesicular liposomes" patented technology

The invention provides a high-stability blueberry anthocyanin polycystic liposome and a preparation method of the high-stability blueberry anthocyanin polycystic liposome. The preparation raw materials comprise 5 to 12 parts of a pH response type phospholipid derivative, 3 to 8 parts of mesoporous silica-polydopamine hybrid nanoparticles, 28 to 42 parts of egg yolk lecithin, 8 to 12 parts of cholesterol, 5 to 9 parts of glyceryl trioleate, 2 to 5 parts of vitamin E succinate, 10 to 18 parts of a citric acid-malic acid buffer solution, 45 to 85 parts of trehalose, 16 to 32 parts of a Tween 80-Arabic gum compound, 4 to 8 parts of chitosan quaternary ammonium salt and 5 to 13 parts of polyethylene glycol-2000. 160-280 parts of ultrapure water and 6-22 parts of blueberry anthocyanin. The blueberry anthocyanin polycystic liposome disclosed by the invention has high encapsulation efficiency, excellent photo-thermal stability and long-term storage stability.

The invention discloses treprostinil multivesicular liposome for treating pulmonary arterial hypertension. The multivesicular liposome is prepared from an inner water phase, an oil phase and an outer water phase through a double emulsification method, the treprostinil is dissolved in the inner water phase; the oil phase comprises soybean lecithin, cholesterol, glyceryl trioleate and electronegative lipid; the inner water phase and the outer water phase are body fluid isotonic solutions. The treprostinil multivesicular liposome disclosed by the invention has good stability and high encapsulation efficiency, obviously reduces burst release effect, shows obvious slow release characteristic, is beneficial to prolonging in-vivo drug half-life period, and can realize 48-hour treatment, reduce administration frequency, simplify administration method and improve patient compliance through simple subcutaneous injection. After the treprostinil multivesicular liposome is injected once, the inflammatory reaction of the injection part can be eliminated within 7 days, and the treprostinil multivesicular liposome has good safety.

The present disclosure relates to a new and improved large scale commercial manufacturing process of making bupivacaine multivesicular liposomes (MVLs) comprising DPEC, DPPG, cholesterol and tricaprylin. Batches of bupivacaine MVLs prepared by the new process have high yields, improved stability profiles, and desired particle size distributions.

Embodiments of the present disclosure relate to a new and improved large scale commercial manufacturing process of making bupivacaine multivesicular liposomes (MVLs). Batches of bupivacaine MVLs prepared by the new process have high yields, improved stabilities, and desired particle size distributions.

Embodiments of the present application relate to commercial manufacturing processes for making bupivacaine multivesicular liposomes (MVLs) using independently operating dual tangential flow filtration modules.

The application discloses an analysis method of a multivesicular liposome composition and belongs to the technical field of drug analysis. The analysis method is characterized by adopting a C8 chromatographic column, a buffer aqueous solution and an organic phase as a mobile phase, gradient elution, analysis and separation of composition components and hydrolysis products of the multivesicular liposome composition, and quantitative calculation of the composition components and the hydrolysis product content. The application is favorable for better monitoring of the quality of the multivesicular liposome composition product and provides a powerful guarantee for development of the multivesicular liposome composition.

The present application relates to the field of food health care technology, and particularly relates to mulberry leaf extract polycapsule liposome, a preparation method, health food and a blood sugar reducing application thereof; the mulberry leaf extract polycapsule liposome comprises mulberry leaf extract and blank polycapsule liposome; the mulberry leaf extract comprises mulberry leaf flavone and mulberry leaf alkaloid; the blank polycapsule liposome is composed of lipid bilayer, and comprises a plurality of aqueous chambers inside and is separated by the lipid bilayer between the aqueous chambers; wherein the mulberry leaf flavone is located between the lipid bilayers, and the mulberry leaf alkaloid is located inside the aqueous chambers. The mulberry leaf extract polycapsule liposome provided by the present application can simultaneously achieve embedding of the mulberry leaf flavone and the mulberry leaf alkaloid, thereby better achieving a blood sugar reducing effect.

The present disclosure relates to a new and improved large scale commercial manufacturing process of making bupivacaine multivesicular liposomes (MVLs) comprising DPEC, DPPG, cholesterol and tricapryl

The present application relates to the technical field of hydrogel and its preparation, and discloses a chitosan-based gradient hydrogel, a preparation method and application thereof, wherein thiolated chitosan and curcumin-loaded multivesicular liposomes are dissolved in an alpha-ketoglutaric acid aqueous solution, N-hydroxysuccinimidyl acrylate and hydroxyapatite are dissolved in another deionized water, and the two solutions are mixed, and the pH value of the system is adjusted to neutral to obtain a bone layer gel. According to the above gel preparation method, the hydroxyapatite is replaced by cartilage root to obtain a cartilage layer gel. The bone layer gel is placed at the bottom layer, and the cartilage layer gel is placed at the top layer, and a chitosan-based gradient hydrogel is prepared integrally. The chitosan-based bone-cartilage gradient hydrogel constructed by the present application can better simulate the bone-cartilage gradient structure and the bone-cartilage interface, the cartilage layer gel promotes chondrogenesis, the bone layer gel promotes osteogenesis, and the slow release of curcumin adjusts the inflammatory microenvironment to maintain the phenotype.