102 results about "Self-healing hydrogels" patented technology

The invention relates to a preparation method of injectable natural polysaccharide self-healing hydrogel. The preparation method of the injectable natural polysaccharide self-healing hydrogel comprises the following steps: firstly synthesizing water soluble N-carboxyethyl chitosan by carrying out a Michael addition reaction on acrylic acid and chitosan, carrying out an oxidization reaction on sodium periodate and sodium alginate to obtain oxidized sodium alginate, then carrying out a dehydration condensation reaction on N-carboxyethyl chitosan and oxidized sodium alginate and on adipic dihydrazide and oxidized sodium alginate in a phosphate buffer liquid at the temperature of 37 DEG C, so as to respectively generate invertible imine bond and acylhydrazone bond, and finally preparing injectable natural polysaccharide macromolecular hydrogel with self-healing property. The preparation method of the injectable natural polysaccharide self-healing hydrogel has the advantages that a synthetic process of the injectable self-healing hydrogel is simple and green, reaction conditions are mild, the injectable self-healing hydrogel can form gel in a physiological environment and has self-healing capability, and the injectable self-healing hydrogel has a good application prospect in the fields of drug sustained release and the like.

The invention relates to a self-healing hydrogel polyelectrolyte and preparation and application thereof. The polyelectrolyteis is prepared by copolymerizing-2-acrylamide-2-methylpropane sulfonic acidand N, a nN-dimethyl acrylamide monomer, and the lithium celite and graphene oxide are prepared by double crosslinkers. . Compared with the prior art, the present invention not only has higher tensile strength, but also exhibits excellent and repeatable self-healing performance under heating or infrared light irradiation. the hydrogel is used as both an electra olyte and diaphragm, a wrinkled electrode is fabricated by pre-stretching method. The supercapacitor has super stretchability (1000%) and excellent self-healing performance. Moreover, the healing supercapacitor still maintains about 900% stretchability. The self-healing and high tensile supercapacitor in the invention has simple structure and preparation process, and has wide application prospect in portable flexible and wearable devices.

The invention discloses self-healing hydrogel capable of promoting wound healing and cancer therapy and preparation method thereof. The self-healing hydrogel is FCB hydrogel which is prepared by Schiff base reaction among a polyether-cationic polymer water solution with a mass concentration as 8% to 50%, a polyether-p-hydroxy benzaldehyde water solution with a mass concentration as 10% to 40% anda dopamine modified biological active inorganic material water solution with a mass concentration as 2% to 10%, the water solutions are mixed according to a volume ratio of (22 to 28) to (7 to 10) to(4 to 10), the F is polyether-cationic polymer, the C is polyether-p-hydroxy benzaldehyde, and the B is a dopamine modified biological active inorganic material. The self-healing hydrogel has good biological compatibility, better photo-thermal character and stronger antibacterial property; under laser radiation, the self-healing hydrogel can effectively inhibit animal cancer growth; furthermore, the self-healing hydrogel can promote mouse skin damage repair. The preparation method has the advantages of simpleness, no organic solvent residue, environment-friendly synthesizing method, convenience in operation and low raw material cost.

The invention relates to a preparation method of a self-healing hydrogel and belongs to the technical field of biomedical high-molecular materials. The preparation method comprises adding dopamine into an alkaline solution so that dopamine self-polymerizes to form a dopamine prepolymer; adding N,N'-methylene bisacrylamide, ammonium persulfate, acrylic acid and N,N,N',N'-tetramethylethylenediamineso that the hydrogel is formed through polymerization of their free radicals. Compared with the prior art, the self-healing hydrogel prepared herein has the advantages that operation is simple, conditions are easy to control, the self-healing hydrogel is available for industrial production, the reaction conditions are mild, and the cost is low. Hydrogels with different adhesive features and tensile properties can be prepared according to actual needs.

The invention discloses self-healing hydrogel of a cellulose-dopamine-polymer composite material as well as a preparation method and application of the self-healing hydrogel. The preparation method disclosed by the invention comprises the following steps: 1) preparing a cellulose solution; 2) under a heating condition, dissolving epichlorohydrin into a cellulose solution and reacting to obtain a first mixed solution; 3) cooling; dissolving the dopamine into the first mixed solution to obtain a second mixed solution; 4) under an ice water bath, adding a polymer monomer into the second mixed solution; then adding an initiator, a double-cross-linking agent and a catalyst to obtain a third mixed solution; 5) molding the third mixed solution to obtain a product. The invention further disclosesapplication of the self-healing hydrogel. The self-healing hydrogel of the cellulose-dopamine-polymer composite material, disclosed by the invention, has the advantages of wide raw material source andbiodegradability and good electrical conductivity and mechanical performance; the preparation method is simple to operate and has relatively short reaction time, and the self-healing hydrogel has biocompatibility and biodegradability.

The invention relates to a hydrogel and discloses a low-temperature-resistant self-healing hydrogel preparation method and application. The method includes: respectively subjecting polyvinyl alcohol powder and borax to heating and stirring in redox graphene mixed solution of ethylene glycol and deionized water to completely dissolve to form uniform PVA mixed solution and borax mixed solution; adding equal-mass borax mixed solution into the PVA mixed solution, and slowly stirring at 90 DEG C to enable complete cross-linking gelatinization; subjecting a gelatinization product to compression moulding in a mould to form dual reticulated PVA-Rgo/H2O-Eg hydrogel. The hydrogel has high stability and high sensitivity coefficient in a range of -10-60 DEG C. The low-temperature-resistant self-healing hydrogel preparation method is simple, and the prepared hydrogel is extensive in raw material and excellent in toughness, low-temperature resistance and self-healing property, can be used for preparation of high-sensitivity resistance strain sensors and has a promising application prospect in fields of flexible robots, intelligent wear and the like.

The invention provides a self-repaired hydrogel and a preparation method thereof. A copolymer of cyclodextrin and epoxy chloropropane and azophenyl acrylamide are subjected to a host-guest complexing effect to obtain a crosslinking agent; and the crosslinking agent is copolymerized with water-soluble monomers such as acrylamide to obtain a hydrogel material. After the material is damaged, the fracture surfaces of the material are repaired through the host-guest complexing effect between trans-azobenzene and cyclodextrin; by applying ultraviolet irradiation to the fracture surfaces of the material, the azobenzene group is turned into a cis form, and the self-repairing ability disappears; and by applying blue light irradiation to the fracture surfaces of the material, the azobenzene group is turned into a trans form, and the self-repairing ability recovers. The material provided by the invention is hopefully applied to the fields such as drug release, optical storage, optical switches and anti-forgery technology.

The invention discloses a self-repairing flexible printed circuit board and a preparation method thereof. A base material of the circuit board is prepared from self-repairing hydrogel elastomers based on dynamic boric acid ester bonds and prepared from, by weight, 30-70 parts of hydrophilic group containing allyl monomers or polymers, 5-35 parts of hydroxide group containing allyl monomers or polymers, 2-8 parts of boron compounds, 15-35 parts of water and 0.5-1 part of radical initiator. The hydrogel elastomers achieve a self-repairing function through dynamic boric acid ester bonds formed by hydroxide groups and boric acid radicals, the boric acid ester bonds serve as dynamic covalent bonds, the strength of covalent bonds and the reversibility and plasticity of physical crosslinking are achieved, therefore, the material achieves the self-repairing performance, and the service life of the material is prolonged. Meanwhile, the raw materials are cheap and easy to obtain, the preparation process is simple, and good comprehensive mechanical performance is achieved.

The invention discloses dual-network hydrogel with high-toughness, shape-memory and self-repairing characteristics and a preparation method of the dual-network hydrogel. The dual-network hydrogel is formed by alternate arrangement of dual networks, a first network is a dynamic imine linkage network formed by Schiff base reaction of chitosan and polyethylene glycol with aldehyde groups at two ends,and a second network is a polyacrylamide cross-linked network. The preparation method mainly includes: dissolving N-carboxyethyl chitosan, acrylamide, N,N'-methylene bisacrylamide into water according to a certain proportion, and adding modified polyethylene glycol and ammonium persulfate mixed solution; performing reaction at 30-50 DEG C to obtain the dual-network hydrogel. The dual-network hydrogel prepared according to the preparation method is excellent in mechanical performance and self-repairing performance and has a shape memory performance of pH and metal ion stimulation response, anapplication range of chitosan self-repairing hydrogel materials is further expanded, and the dual-network hydrogel is hopefully applied to fields of wearable flexible electronic devices, software robots, biomedicine, aerospace engineering and the like.

The invention provides nuclear magnetic resonance visual injectable pH sensitive self-repairing water gel. The gel consists of DTPA-modified chitosan (component A) and polyethylene glycol (component B) of which two ends are subjected to hydroformylation, and the component A solution complexed with Gd<3+> and the component B solution are mixed in a short time at room temperature so as to form in-situ gel. The gel has the pH sensitive self-repairing characteristic, a developing agent is not needed to be repeatedly injected to a patient, and developing can be guaranteed for a long time by using MRI (Magnetic Resonance Imaging), so that the lesion risk caused by Gd<3+> enrichment is reduced. The water gel provided by the invention can serve as drug carriers, embolism or filling materials and tissue scaffold materials in clinical application.

The invention belongs to the technical fields of new materials and sensors and discloses a preparation method of a PAA (polyacrylic acid) bi-crosslinking network self-healing hydrogel capacitive pressure sensor. According to the method, first, acrylic acid and acrylamide are used as base materials, iron ions are added to form coordination, and a uniform physical and chemical crosslinking double-layer three-dimensional net structure is formed. Obtained hydrogel has strong mechanical properties and quick self-healing characteristics. In order to fully utilize the characteristics of the hydrogel,the hydrogel is made into the capacitive pressure sensor of a "sandwich" structure with conducting layers at two ends being the self-healing hydrogel and a middle dielectric layer being PDMS. The preparation method is simple and wide in material source, has good electrochemical and mechanical properties and has a broad application prospect in the field of flexible wearable materials.

The invention provides a self-healing binder for a silicon-based negative electrode material for a lithium battery, the silicon-based negative electrode material for the lithium battery, a preparationmethod of the silicon-based negative electrode material, a negative electrode of the battery and the lithium battery. The double-crosslinking self-healing binder comprises a polysaccharide polymer containing a polar group or a synthetic polymer containing the polar group and metal ions, preferably polyacrylic acid (PAA) and Fe<3+> ions. The binder comprises a network structure built through esterification crosslinking of the PAA, and meanwhile, secondary crosslinking is achieved through interaction between ions of the Fe<3+> and the PAA; the PAA is induced through the Fe<3+> to form a self-healing hydrogel system; the self-healing binder can play a double-crosslinking role in the silicon negative electrode material and can play a repairing role in mechanical damage of the electrode in thecharge-discharge cycle process; the energy consumption is extremely low, and meanwhile, the adverse effects of repeated volume changes of the silicon negative electrode in the charging and discharging processes of the battery are avoided; the cycle performance of the silicon-based negative electrode material is improved; the capacity attenuation of the battery is small; and the defects of the prior art are overcome.

The invention provides a preparation method of bi-physically-crosslinked self-repairing hydrogel. MMT (montmorillonite), AM (acrylamide), hydrophobic monomer SMA (stearyl methacrylate) and SDBS (sodium dodecyl benzene sulfonate) are taken as main raw materials and blended to form a precursor, and HPAAm/MMT compound hydrogel is obtained after micelle in-situ polymerization of the precursor. The raw materials are cheap and easy to obtain and the preparation process is simple. Hydrogel is dual-crosslinked in the presence of micelle and under the physical adsorption action of MMT and AM, and the mechanical strength is improved to 0.23 MPa; gel can recover to original morphology and performance after being repaired at 60 DEG C for 5 h. The prepared self-repairing hydrogel has broad application prospect in medical suture, industrial sealing, self-repairing elastomers and other fields.

The invention discloses a chitosan derivative self-healing hydrogel and a preparation method and applications thereof. The preparation method of the chitosan derivative self-healing hydrogel includesthe steps of taking and separately dissolving chitosan derivatives and polyvinyl alcohol in deionized water to be then mixed and evenly stirred at a temperature of 30-40 DEG C to obtain a polymer solution, dissolving acrylamide in the deionized water and then adding mixed crosslinking agents therein, adding initiators therein after stirring for 10-15 minutes, adding the mixture into a polymer solution after stirring for 10 to 15 minutes under the protection of nitrogen, fully and evenly stirring the mixture to obtain a composite solution, adding catalysts to the composite solution to be rapidly mixed for 20-60 seconds, and then conducting heat preservation of the composite solution at a temperature of 35-45 DEG C for 8-12 hours obtain the self-healing hydrogel. The prepared chitosan derivative self-healing hydrogel has the advantage of good prospects in the application of Cr6+ (hexavalent chromium) adsorption removal.

The invention discloses high-toughness self-repairing physical hydrogel based on dual ion coordination and a preparation method thereof. The physical hydrogel has multi-crosslinking sites. The preparation method of the high-toughness self-repairing physical hydrogel comprises the following steps: dissolving N-carboxyethyl chitosan (CEC), acrylic acid (AA), an FeCl3 water solution and a CaCl2 watersolution into de-ionized water according to a certain ratio and carrying out ultrasonic treatment to obtain a uniform and transparent solution; then carrying out vacuum deoxygenation on the solution;adding an ammonium persulfate (APS) water solution and a catalyst N,N,N',N'-tetramethyldiethylamine (TEMED) in sequence under the protection of nitrogen gas; reacting for at least 4h under the condition of 30 to 50 DEG C, so as to prepare the physical hydrogel. The physical hydrogel provided by the invention has excellent mechanical properties and self-repairing properties; metal ions are introduced so that the gel has certain ionic conductivity; furthermore, an application range of the chitosan based self-repairing hydrogel is expanded; the high-toughness self-repairing physical hydrogel ishopefully applied to fields including wearable flexible electronic devices, soft-bodied robots, biomedicines, aerospace and the like.

The invention provides self-healing hydrogel entrapping exosome as well as a preparation method and application thereof. The preparation method comprises the following steps: performing reaction modification on methylcellulose and p-aldehyde benzoic acid to obtain aldehyde methyl cellulose; performing amidation reaction on chitosan and methyl polyethylene glycol to obtain pegylated chitosan whichis dissoluble under the neutral condition; and separating from placental mesenchymal stem cell supernatant by a centrifugal method to obtain the exosome, mixing the exosome, the aldehyde methyl cellulose and the pegylated chitosan to form a crosslinked network structure of dynamic reversible Schiff base through the aldehyde on the aldehyde methyl cellulose and the amino in the pegylated chitosan molecule. The self-healing hydrogel can be applied to skin trauma repair at exercise site. The gel has antibacterial property and the exosome shows sustained-release effect in the gel, so that the self-healing hydrogel entrapping the exosome has high biocompatibility, high self-healing property and degradation rate.

The invention discloses a preparation method of a self-repairing hydrogel based on double-selenium dynamic covalent bond and quadruple hydrogen bond. The hydrogel is prepared from the following steps:enabling the diisocyanate, polyethylene glycol, di-selenium diol, UPy-based chain extender and crosslinking agent trimethylolpropane to react in tetrahydrofuran to obtain organic gel, and soaking theorganic gel in deionized water to remove the solvent and unreacted micromolecule. The hydrogel can realize the repeatable fast self-repairing on the injury under the mild visible irradiation based onthe dynamic feature of the di-selenium dynamic covalent bond under the visible irradiation and the UPy quadruple hydrogen bond fast fracturing-recombining feature, the damage on the material structure by the high-temperature, ultraviolet irradiation and other stronger external stimulus required by the traditional self-repairing is avoided. The hydrogel is a polyurethane structure taking the polyethylene glycol as the hydrophilia soft segment, and has excellent biocompatibility and molecular structure designability; the actual application requirement can be well satisfied, and the hydrogel hasa extensive application prospect in the field of the biological tissue engineering.

The invention relates to a self-healing hydrogel electrolyte film, and a preparation method and an application thereof. The electrolyte film is prepared by copolymerization of [2-(methylacryloyloxy)ethyl]dimethyl-(3-sulfonic acid propyl)ammonium hydroxide and a methacrylic acid monomer. Compared with the prior art, the hydrogel electrolyte film disclosed by the invention not only has very high tensile strength, but also shows excellent repeatable self-healing performance. The hydrogel film is used as an electrolyte, and a wrinkled electrode is prepared on the surface of the hydrogel electrolyte film by a pre-stretching method; a flexible supercapacitor prepared from the hydrogel film has good tensile property (1,000%) and self-healing performance, and the healed supercapacitor shows the energy storage performance consistent with that of an original device. The high-tensile and self-healing supercapacitor is relatively simple in structure and preparation process, and has a wide application prospect in the field of flexible stretchable electronic devices.

The invention relates to a preparation method of a dynamic covalent crosslinking agent. The preparation method comprises following steps: dissolving a first micro molecule and a second micro moleculeinto an organic solvent, wherein one end of the first micro molecule is an o-dihydroxyl group, the other end is an amino group; one end of the second micro molecule is isocyanate/acyl chloride, and the other end is a polymerizable carbon-carbon double bond; carrying out reactions at a temperature of 20-30 DEG C in a protective atmosphere to make the amino group and isocyanate/acyl chloride carry out reactions to obtain a polymerizable monomer, whose tail end contains a dihydroxyl group; and reacting the monomer containing a tail end dihydroxyl group with a water solution containing tetrahydroxyl borate radicals at a temperature of 20-30 DEG C. The invention also provides a self-repairing hydrogel preparation method based on the dynamic covalent crosslinking agent mentioned above. The dynamic covalent crosslinking agent containing borate bonds and water soluble vinyl monomers are dissolved in water, and the obtained water solution carries out free radical polymerization to obtain the hydrogel. The prepared hydrogel has an excellent stretching performance and a rapid self-repairing performance.

The invention discloses a doxorubicin hydrochloride-loaded self-healing hydrogel drug administration system and a preparation method thereof. The preparation method comprises the steps of oxidating pullulan into aldehyde-rich oxidated pullulan; by taking the oxidated pullulan, epsilon-polylysine, branched polyethyleneimine and doxorubicin hydrochloride as raw materials, performing Schiff base reaction in a water solution to form a dynamic imine bond cross-linked network, thus obtaining the self-healing hydrogel drug delivery system, wherein the doxorubicin hydrochloride is loaded into the system by two modes of dynamic imine bond cross linking and gel mesh adsorption. The preparation method is simple and easy to operate, the obtained hydrogel drug delivery system has good biocompatibility, biodegradability, temperature and pH sensitivity, self-sealing property and syringeability, and can be directly injected into a diseased region by tumor periphery injection drug administration without surgery implantation, thus greatly alleviating the pain of a patient, slowly releasing the doxorubicin hydrochloride in vivo, being beneficial to reducing of toxic and side effects of a drug, and achieving the aim of efficiently attenuating toxicity in a tumor treatment process.

The invention provides a self-catalyzed repairing hydrogel as well as a preparation method and an application thereof. The self-catalyzed repairing hydrogel is generated by reacting (N-isopropylacrylamide)-acrylhydrazine copolymer with a multicarbonyl compound in an aqueous solution, wherein a molar ratio of hydrazine groups to carbonyl groups is 1.2-2: 1; the (N-isopropylacrylamide)-acrylhydrazine copolymer comprises a repeating unit A and a repeating unit B. The self-catalyzed repairing hydrogel of the present invention is capable of realizing a self-catalyzed self-repairing process with a biocompatible polymer PN/PAM as a main body and a biocompatible multicarbonyl compound as a cross-linking agent. In such a way, side effects caused by added catalysts are avoided, and dependence on catalysts is decoupled; the biocompatibility of the self-repairing hydrogel and the applicability thereof in the field of biomedicine are guaranteed. As a result, the defect that existing self-repairing hydrogels cannot be actually applied to the relevant art of biomedicine is overcome.

The invention provides fluorescence-responsive self-healing hydrogel and a preparation method thereof. The preparation method includes steps: dissolving polyvinyl alcohol, chitosan and lipopolysaccharide into water at 90-100DEG C to obtain sol, and heating for 1.5h-4h, wherein the mass concentration of polyvinyl alcohol in the sol is 20%-40%; adding a micromolecular compound into the sol to obtaingel, and performing constant-temperature heating at 80-90 DEG C for 1h-2h; adding carbon quantum dot water solution into the gel, and cooling and pressing to obtain the fluorescence-responsive self-healing hydrogel. The fluorescence-responsive self-healing hydrogel has fluorescence responsiveness and great self-healing performance.

The invention provides a multiple-response type self-repair hydrogel material and a preparation method and application thereof. The multiple-response type self-repair hydrogel material is prepared from polydopamine methacrylate-N-isopropylacrylamide, poly-N-isopropylacrylamide-4-vinyl benzeneboronic acid and water. The multiple-response type self-repair hydrogel material has the characteristics that the effects of pH (potential of hydrogen) response and temperature response are realized, the self-repair property is realized, and the application prospect is broad in the fields of biomedical materials, nanometer materials and photoelectric materials.