Nano granule preparations of catharanthus roseus alkaloids anti-tumor medicaments and preparation thereof

Abstract

The invention discloses a naonparticle preparation of periwinkle alkaloids antitumor drug. The particle diameter is between 10 and 150 nm and the raw materials of the naonparticle preparation comprises by weight percentage: 0.1 to 5 percent of the periwinkle alkaloids antitumor drug, 0.5 to 3 percent of carrier, 0.5 to 3 percent of stabilizer and 89 to 98.5 percent of hydrochloric acid solution with pH value of 2; the sum of the weight percentages of the raw materials is 100 percent. The naonparticle preparation of periwinkle alkaloids antitumor drug can effectively enhance sensitivity to tumor cells and reduce the drug toxicity. The preparation method of the invention has the advantages of quick and easy property, low cost, high maneuverability and comparatively narrow particle size distribution, etc.; organic solutions are not adopted in the preparation process, without problem of organic solution residue.

Description

Nanoparticle preparation of vinca alkaloid antitumor drug and preparation method thereof technical field The invention belongs to the field of medicine, and in particular relates to a nanoparticle preparation of vinca alkaloid antitumor drugs and a preparation method thereof. technical background The vinca alkaloid antineoplastic drug is a kind of alkaloid with anticancer activity extracted from the plant periwinkle of Apocynaceae. It mainly inhibits tubulin polymerization, hinders the formation of spindle microtubules, and stops mitosis in metaphase. It can also act on the cell membrane, interfere with the transport of amino acids by the cell membrane, inhibit protein synthesis, and inhibit RNA synthesis. Vinca alkaloid anti-tumor drugs have a wide anti-tumor spectrum and are widely used clinically to treat various cancers, such as leukemia, lymphoma, breast cancer, lung cancer, liver cancer, head and neck cancer and many other solid tumors. Such antineoplastic drugs ma...

AI Technical Summary

Problems solved by technology

But vinca alkaloids antineoplastic drug liposome also has many shortcomings.

Such as: the drug is encapsulated in the inner water phase and released from the liposome quickly, resulting in unstable preparations; usually the cytotoxicity of the drug encapsulated by the liposome is weaker than that of the free drug; in addition, the preparation of the liposome The process is complex and requires the compounding of multiple lipid components (at least two lipid components), particle size control requires special equipment and devices, and is easy to flocculate during storage, so it is not conducive to popularization and application

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