13 results about "Pulmonary tumor" patented technology

This invention provides a lung stem cell peptide for treating pulmonary nodules, its preparation method, and its application, belonging to the field of biopharmaceutical technology. The invention involves inducing iPSCs to differentiate into lung stem cells; culturing the lung stem cells, centrifuging, collecting the supernatant to obtain crude lung stem cell solution; mixing the crude lung stem cell solution with a protease for enzymatic hydrolysis, centrifuging, concentrating, and spray-drying to obtain the lung stem cell peptide for treating pulmonary nodules. This invention optimizes the composition of each culture medium to induce iPSCs to differentiate into lung stem cells, then extracts and separates lung stem cell peptides from these cells. The extracted lung stem cell peptides are intravenously reinfused into the lungs, effectively inhibiting the formation of pulmonary tumor nodules, significantly reducing the number of pulmonary tumor nodules, and without toxic side effects or adverse reactions.

The application discloses a kind of based on soft driver's lung profile one-way deformation control structure of soft robot of simulation lung, the circumferential of central fixed seat is evenly distributed with pneu-net soft driver connected by connector;Between each connector and central fixed seat, one bellows driver is fixedly connected;Trachea is communicated with pneu-net soft driver and bellows driver;Control structure is shown by the radial telescopic characteristics of the radial deformation of lung and the boundary curvature of lung quality of lung by the bending characteristics of the lung of the bellows driver and the pneu-net soft driver respectively by applying air pressure to bellows driver.It is effectively simulated by the driving mode of the above control structure pneumatics when the profile of lung one-way deformation, by multiple different structure parameters this kind of soft driver constitutes complete soft robot of simulation lung, on the basis of being able to accurately control model deformation, be applied to the deformation prediction of lung deformation and accurately predict lung tumor movement space.

The application discloses a recombinant adenovirus vector tumor vaccine and a preparation method and application thereof, wherein the antigen coded by the recombinant adenovirus vector tumor vaccine comprises any one or a combination of more than two antigen peptide epitopes of KRAS protein. The recombinant adenovirus vector tumor vaccine of the application codes multiple KRAS tumor-specific antigen peptides, and has a good killing effect on KRAS mutation-driven tumors, especially lung tumors. The vaccine can be inhaled in a form of atomization, injected into muscles first and then inhaled in a form of atomization, inhaled in a form of atomization first and then injected into muscles, injected into muscles, or simultaneously injected into muscles and administered in a form of atomization. After atomization, the vaccine can be inhaled through a nasal cavity or an oral cavity to reach the lungs, generate an anti-tumor protective immune response on the respiratory tract, the lungs and the whole body, and enhance the utilization rate and the treatment effect of the vaccine.

A tool to create virtual lesions inside a 3D lung tumor image. The image can be an MRI or CT image of a patient's lung to be treated. This virtual pre procedural ablation allows the operator to identify optimal ablation sites and select the optimal ablation parameters for the given anatomy. Also, the actual procedure will be performed with the lung parenchyma surrounding the tumor preventing ultrasound to penetrate beyond the tumor walls. A diagnostic mode will guide the operator to optimize ablation parameters. This virtual pre ablation, the parenchymal ultrasound barrier and the diagnostic catheter operation should enable the operator to conduct the therapeutic procedure safe, fast and effective.

The invention provides a CT embedded percutaneous puncture surgical robot which comprises a mainframe box, a system control box, two mechanical arms, a manipulator and an upper computer, the two mechanical arms extend out of the system control box, and supporting points at the far ends of the two mechanical arms are located in a scanning plane of a CT machine; the outer contour of the mainframe box is in a circular arc shape, and the mainframe box is arranged above the interior of a CT hole of a scanning frame of a CT machine through a supporting point at the far end of the mechanical arm. An arc-shaped sliding rail and a sliding block are arranged in the mainframe box; the manipulator comprises a puncture depth controller, a trocar holder, a trocar and a trocar driver; when in use, the trocar is located in a scanning plane of the CT machine. According to the system, early and early lung tumors can be accurately positioned, a doctor can puncture a tumor part with the puncture trocar to obtain a pathological sample while CT is carried out, and the credibility of a puncture biopsy result reaches 100%.

The invention relates to a lung-targeted drug-loaded micromotor as well as a preparation method and application thereof. The preparation method comprises the following steps: mixing mPEG (Polyethylene Glycol), N-t-Boc-glycine, DMAP (Dimethylaminopyridine), DCC (Dendritic Cellulose) and a solvent for reaction, and sequentially obtaining an intermediate product preparation process of mPEG-CH2CH2NH-Boc, CH3OPEG-NH2 and mPEG-NH2; performing mixed reaction on NHS, EDC and a sodium alginate solution in a buffer system to obtain a carboxyl activation process of an activated product; the mPEG-NH2 and the activated product are mixed and subjected to a reaction, and a precursor material of Alg-g-mPEG is obtained; a saturated alpha-CD aqueous solution of an FOF1-ATPase molecular motor is mixed with the Alg-g-mPEG aqueous solution, and the Alg-g-mPEG self-assembled micro-capsule with the FOF1-ATPase molecular motor coating is obtained in the carrier preparation process; mixing a drug with the self-assembled micro-capsule to obtain a lung-targeted drug-loading micro-motor; the invention further discloses application of the lung-targeted drug-loaded micromotor prepared according to the preparation method in preparation of a drug delivery system for treating lung adenocarcinoma. The double-site high-drug-loading-capacity hydrogel has the advantages of being high in double-site high drug loading capacity, high in biological safety, high in pH response self-driving capacity, good in lung tumor targeting capacity, good in lung retention capacity and the like.

This application relates to the field of medical image processing technology, and discloses a method, system, device, and medium for predicting tumor status, including: acquiring a set of CT images of the lungs of a target object during the current respiratory cycle; constructing a three-dimensional tumor model of the lung tumor based on the CT image set; the lung tumor has a real volume and real centroid coordinates; performing finite element analysis to obtain a finite element tumor model, calculating the simulated volume and simulated centroid coordinates of the lung tumor; comparing and obtaining the volume retention ratio and centroid offset; predicting the motion state of the lung tumor in the next respiratory cycle to obtain the initial motion state parameters of the lung tumor in the next respiratory cycle; if the motion state prediction quality of the lung tumor meets the preset motion state prediction quality based on the volume retention ratio and centroid offset, then the initial motion state parameters are used as the target motion state parameters to predict the motion state of the lung tumor, thereby improving the accuracy and correctness of radiotherapy.

The present invention relates anti-microbial antibody signatures related to lung tumors, including benign tumors and adenocarcinomas. Disclosed herein are antibody panels comprising antigens from bacteria and / or viruses for use in early and accurate diagnosis of lung cancer and for reducing false positive lung carcinoma diagnoses from CT screening.

The invention belongs to culture of tumor organoids, and particularly relates to a preparation method of tumor organoids, which comprises the following steps: digesting a lung tumor sample to obtain an epithelium starting material, performing three-dimensional culture on a basement membrane matrix to form primary organoids, and performing early cryopreservation in a main library; homologous organs are homogenized and subpackaged into test groups, and after adaptive culture is carried out under a combination of multiple culture media, chemotherapy pressure is applied, and elution recovery is carried out; a target culture medium combination for screening the drug-resistant subgroups is determined according to survival and regrowth and in combination with a normal sample removal result of morphology; according to the method, the proportion of tumor components is increased, the drug-resistant survival subgroups are enriched, and the preparation consistency and repeatability are improved.

The application belongs to the field of traditional Chinese medicines, and particularly discloses application of a leech dredging collaterals preparation in preparation of an anti-tumor medicine. The leech dredging collaterals preparation is prepared from four raw medicinal materials of astragalus, ligusticum wallichii, leech and salvia miltiorrhiza, and has the effects of tonifying qi and activating blood and dredging qi and collaterals. Pharmacodynamic studies show that the leech dredging collaterals preparation has the effects of inhibiting growth of liver tumors and lung tumors, is safe and has a good effect, expands the clinical application range of the leech dredging collaterals preparation, and has a good popularization and application prospect.

The invention discloses a lung tumor ablation thermal field prediction method based on adaptive mesh generation. The lung tumor ablation thermal field prediction method comprises the following steps: S1, constructing a three-dimensional lung structure model according to three-dimensional medical imaging data; s2, calibrating a tumor focus range in the three-dimensional lung structure model, and generating an initial basic coarse grid; s3, obtaining an initial temperature distribution result; s4, obtaining a grid encryption demand distribution map; s5, performing local refining and global sparse processing on the initial basic coarse grid according to the grid encryption demand distribution diagram, and updating a local heat loss weight matrix in real time; s6, if the preset convergence criterion is not met, updating is carried out, and a next round of adaptive grid structure is generated until the preset convergence criterion is met; and S7, generating a lung tumor ablation thermal field evolution simulation report. According to the method, the generalization ability and the local heat conduction simulation accuracy of the model among different patients are remarkably improved, and higher prediction credibility is shown in patient groups with obvious perfusion intensity differences.

In one or more implementations, systems, methods and computer implemented processes are provided that are directed to a method of treating a subject with a lung tumor, the method comprising: obtaining computed tomography (CT) image slices of the subject, wherein the CT image slices comprise images of the lung tumor. In a further implementation, the systems, methods and computer implemented processes are directed to identifying a first CT image slice where the lung tumor has a largest diameter among the CT image slices; and determining intensity-skewness of the lung tumor on the first CT image slice. In a further implementation, the systems, methods and computer implemented processes are directed to treating the subject with surgery, chemotherapy and / or radiotherapy, if the intensity-skewness is no greater than-1.5.