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Drug composition suitable for transdermal drug delivery and containing granisetron as well as preparation and application of same

A technology of granisetron and composition, which is applied in the pharmaceutical composition containing granisetron suitable for transdermal administration and its preparation and application field, to achieve the improvement of cohesive strength and adhesive performance, small skin irritation, The effect of adequate bond strength

Inactive Publication Date: 2013-02-06
JIANGSU KANGBEIDE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the prior art lacks a granisetron-containing transdermal patch that can more effectively increase the transdermal flux of granisetron, and simultaneously take into account or even improve skin irritation and mechanical properties

Method used

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  • Drug composition suitable for transdermal drug delivery and containing granisetron as well as preparation and application of same
  • Drug composition suitable for transdermal drug delivery and containing granisetron as well as preparation and application of same
  • Drug composition suitable for transdermal drug delivery and containing granisetron as well as preparation and application of same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] In a suitable container, weigh out 1.47 g RS100 (produced by Germany Evonik Degussa company), then add an appropriate amount of ethyl acetate (Beijing Yili Fine Chemicals Co., Ltd., chemically pure) to soak for 2-3 hours to make it completely dissolved, then weigh 24.42 grams of 30% solid content Polyacrylate pressure-sensitive adhesive (for its preparation method see: Yang Yukun, "Technical Handbook of Pressure-Sensitive Adhesive Products", Chemical Industry Press, published in September 2004, pages 260-261), wherein the monomers used and their contents are respectively: Acrylamide 3.8%, butyl acrylate 33.1%, 2-ethylhexyl acrylate 40.9%, vinyl acetate 21%, and α-methacrylic acid 1.2%. The above monomers were all purchased from Beijing Yili Fine Chemicals Co., Ltd. (chemically pure), and then 0.55 grams of granisetron (Sinopharm Group Chuankang Pharmaceutical Co., Ltd.) and 1.04 grams of isopropyl myristate (Kunshan City, Jiangsu Province) were added. Huaxin Daily Che...

Embodiment 2

[0037] Using the method of Example 1, according to the weight percentage of each component in the matrix layer given in Table 1, the patch of Example 2 was prepared.

Embodiment 3-6

[0039] Using the method of Example 1, according to the weight percentage of each component in the matrix layer given in Table 2, the patches of Examples 3-6 were prepared.

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PUM

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Abstract

The invention relates to a drug composition containing granisetron. The drug composition comprises a sodium polyacrylate pressure-sensitive adhesive (A), a polyacrylic resin (B), a penetration enhancer (C) and granisetron (D), wherein the sodium polyacrylate pressure-sensitive adhesive (A) is a (methyl) acrylate copolymer containing (methyl) acrylamide or N, N-substituted monomer thereof; the polyacrylic resin (B) is an Eudragit polyacrylic resin; and the penetration enhancer (C) is selected from isopropyl myristate, azone, glyceryl triacetate and 1, 2-propylene glycol as well a a mixture thereof. A granisetron transdermal patch containing the drug composition obtains satisfactory technical effects on mechanical property, skin irritation and the like; more importantly, the transdermal patch obtains considerable transdermal flux when the excellent performances are guaranteed.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing granisetron suitable for transdermal administration, a preparation method and application thereof. The pharmaceutical composition is composed of a specific adhesive composition, a penetration enhancer and granisetron in a certain proportion. The transdermal patch containing the pharmaceutical composition further improves the transdermal flux of granisetron while meeting the requirements of skin irritation and mechanical properties. Background technique [0002] Granisetron is a potent, highly selective peripheral and central nervous system serotonin (5-HT 3 ) receptor antagonists, through 5-HT on the ventral centripetal nerve fibers and nucleus of the solitary tract or the emetic chemoreceptor trigger zone of the small intestine 3 Receptor blocking effect, inhibits nausea and vomiting caused by antineoplastic drugs and radiotherapy. At present, the commonly used routes of administratio...

Claims

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Application Information

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IPC IPC(8): A61K31/439A61K9/70A61K47/32A61K47/14A61K47/22A61K47/10A61P1/08
Inventor 刘泽源陆玉成潘悦王丽薛慧勇石晓燕宋莉迟国华王树明
Owner JIANGSU KANGBEIDE PHARMA
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