Crosslinkable pressure-sensitive adhesive for skin

Inactive Publication Date: 2007-08-23
NIPRO PATCH
View PDF2 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0016] According to the invention, there is provided a crosslinkable pressure-sensitive adhesive for skin that has satisfactory adhesion and release properties for skin and low irritation to skin without using low molecular crosslinking agents, and a pressure-sensitive adhesive sheet for skin suitable for medical or cosmetic use. There is further provided a composition for production of a crosslinkable pressure-sensitive adhesive for skin that is stable even with prolonged storage. The crosslinkable pressure-sensitive adhesive for skin of the invention has the following features. (1) Since copolymer A does not contain acrylic acid, does not have the excessively strong cohesion of acrylic acid-based pressure-sensitive adhesives and produces no carboxylic acid-induced ski

Problems solved by technology

Also for removal, they must be peelable with a degree of force that does not cause pain, and if the adhesion is stronger than necessary it can result in plucking of hairs and peeling of the corneum, as well as mechanical skin irritation by pulling of the skin.
Such crosslinking is achieved almost entirely by using the acrylic acid in an acrylic copolymer, but its drawbacks include the facts that (1) the adhesion is excessively strong or chemical activity of the acrylic acid causes significant skin irritation, (2) in percutaneous absorption preparations containing drugs, the acrylic acid and basic drug interact and impede migration of the drug from the pressure-sensitive adhesive into the skin, thereby reducing the percutaneous absorption, and (3) polyisocyanate used as the crosslinking agent is highly active and often reacts with drugs, thereby impairing drug stability.
However, while percutaneous absorption preparations using this type of pressure-sensitive adhesive have satisfactory drug percutaneous absorption and stability, the cohesive strength is insufficient when

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Crosslinkable pressure-sensitive adhesive for skin
  • Crosslinkable pressure-sensitive adhesive for skin

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0059] After adding 5 parts of the solution obtained in Copolymer B Production Example 1 to 100 parts of the solution obtained in Copolymer A Production Example 1, the two solutions were uniformly stirred with a dissolver to obtain a mixture. The obtained mixture was coated onto a silicone-treated PET (polyethylene terephthalate) film with a thickness of 35 μm to a post-drying pressure-sensitive adhesive layer thickness of 100 μm and dried, and then the pressure-sensitive adhesive layer was laminated on the PET layer of a PET / EVA (ethylenevinyl acetate copolymer) laminated film with a thickness of 35 μm to obtain a pressure-sensitive adhesive sheet for skin.

example 2

[0060] After adding 4 parts of the solution obtained in Copolymer B Production Example 1 and 20 parts of isopropyl myristate as a plasticizer to 100 parts of the solution obtained in Copolymer A Production Example 1, the components were uniformly stirred with a dissolver to obtain a mixture. The obtained mixture was used for the same procedure as in Example 1 to obtain a pressure-sensitive adhesive sheet for skin.

example 3

[0061] After adding 4 parts of the solution obtained in Copolymer B Production Example 2 and 30 parts of isopropyl palmitate as a plasticizer to 100 parts of the solution obtained in Copolymer A Production Example 2, the components were uniformly stirred with a dissolver to obtain a mixture. The obtained mixture was used for the same procedure as in Example 1 to obtain a pressure-sensitive adhesive sheet for skin.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Percent by massaaaaaaaaaa
Percent by massaaaaaaaaaa
Percent by massaaaaaaaaaa
Login to view more

Abstract

It is an object of the invention to provide a crosslinkable pressure-sensitive adhesive for skin that exhibits satisfactory adhesion and releasability for human skin and low irritation to skin, and a crosslinkable pressure-sensitive adhesive sheet for skin that is suitable for medical and cosmetic use, as well as to provide a composition for production of a crosslinkable pressure-sensitive adhesive for skin that has superior storage properties and is suitable for preparation of the crosslinkable pressure-sensitive adhesive for skin. The crosslinkable pressure-sensitive adhesive for skin of the invention is formed by 100 parts by weight of an acrylic copolymer (copolymer A) comprising a (meth) acrylic acid alkyl ester as the main constituent component and 3-45 wt % diacetoneacrylamide as an essential constituent component, and containing no free carboxyl groups, and 0.1-30 parts by weight of an acrylic copolymer (copolymer B) comprising a (meth)acrylic acid alkyl ester as the main constituent component and a primary amino group and/or carboxyhydrazide group on a side chain, and containing no free carboxyl groups. A composition of copolymer A and copolymer B dissolved in a solvent containing at least 5.0 wt % acetone and/or butanone with respect to the total amount of solvent can be stored for prolonged periods.

Description

TECHNICAL FIELD [0001] The present invention relates to a crosslinkable pressure-sensitive adhesive for skin, to a crosslinkable pressure-sensitive adhesive sheet for skin employing it, to a composition for production of the crosslinkable pressure-sensitive adhesive for skin and to a process for production of the crosslinkable pressure-sensitive adhesive for skin. BACKGROUND ART [0002] Pressure-sensitive adhesive sheets for skin, in general, must reliably adhere for about 24 hours after being attached to skin and must also adhere without peeling during perspiration and bathing. Also for removal, they must be peelable with a degree of force that does not cause pain, and if the adhesion is stronger than necessary it can result in plucking of hairs and peeling of the corneum, as well as mechanical skin irritation by pulling of the skin. Consequently, this creates erythema that may persist for several days even after peeling, and therefore it is necessary to minimize this inconvenience....

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C08G63/08A61K9/70A61F13/02A61K47/32A61L15/58C08L33/14C08L33/24C09J7/02C09J133/06
CPCA61K8/8158A61K9/7061A61L15/585A61Q19/00A61L24/043C08L33/24C08L33/14C08L2666/04A61F13/02A61K9/70A61K47/32
Inventor KAMIYAMA, FUMIOQUAN, YING SHUKAWAMURA, NAOHISASAWADA, HIDENORI
Owner NIPRO PATCH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap