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Application of blumea oil inclusion compound in preparation of medical spray for treating asthma

A technology of clathrate and mugwort leaf oil, which is applied in the direction of aerosol delivery, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., to achieve the effect of alleviating asthma, low toxic and side effects, and small bronchial irritation

Pending Publication Date: 2022-06-28
ZHENGZHOU UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the use of Artemisia argyi volatile oil as a medicinal ingredient or the inclusion compound of Artemisia argyi volatile oil to make medical sprays to prevent and / or treat asthma

Method used

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  • Application of blumea oil inclusion compound in preparation of medical spray for treating asthma
  • Application of blumea oil inclusion compound in preparation of medical spray for treating asthma
  • Application of blumea oil inclusion compound in preparation of medical spray for treating asthma

Examples

Experimental program
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Effect test

Embodiment 1

[0030] The influence of the argyi leaf oil inclusion compound of the present invention on the asthma of mice induced by OVA and aluminum hydroxide.

[0031] 60 healthy female BALB / C mice, weighing 18-22 g, were provided by Henan Provincial Animal Experiment Center. Mice were adaptively reared for one week in the SPF animal room of the School of Pharmacy, Zhengzhou University, Henan Province, and were divided into 5 groups by random number table method, with 12 mice in each group, as follows:

[0032] 1. Normal control group; (C)

[0033] 2. Model control group; (M)

[0034] 3. Positive control drug group; (B)

[0035] 4. High-dose group of argyi leaf oil inclusion complex. (AH)

[0036] 5. The low-dose group of argyi leaf oil inclusion complex. (AM)

[0037] After the acclimation period, modeling + drug administration was started. First, on the 0th, 7th and 14th days, the model control group, the argyi leaf oil inclusion compound group, and the positive control group we...

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Abstract

The invention belongs to the field of traditional Chinese medicine preparations, and particularly relates to application of a blumea oil clathrate compound in preparation of a medical spray for treating asthma. The invention provides a novel application of folium artemisiae argyi volatile oil as an effective component in preparation of a medical spray for treating asthma. The application amount of the blumea oil clathrate compound in mice is 13.89 mg / kg and 6.96 mg / kg, and after the blumea oil clathrate compound is dosed, the inflammatory cytokines in BALF of the mice and the OVA-sIgE level in serum of the mice can be reduced. The total number of leukocytes in mouse BALF (bronchoalveolar lavage fluid) is reduced, and infiltration of lung tissue inflammatory cells and secretion of airway mucus are inhibited. The composition has the advantages of simple preparation process, low toxic and side effects, naturalness, safety and the like. The invention develops a new application of the blumea oil, and provides a new direction for improving the phenomena of many adverse reactions and great toxic and side effects of the current medicines for treating asthma.

Description

technical field [0001] The invention relates to the field of medical technology, belongs to the field of traditional Chinese medicine preparations, and particularly relates to the application of a argyi leaf oil inclusion compound in preparing a medical spray for treating asthma. Background technique [0002] Bronchial asthma, referred to as asthma, is a chronic inflammatory lung disease. In recent years, the prevalence of asthma has been increasing worldwide, posing a great threat to human health. It is one of the global health problems that attracts much attention. (Zhao Wenjuan, Han Niping, Chen Jing, et al. Experimental study on the regulation of airway inflammation and Th subgroup-related cytokines by Shengsanqi powder in asthmatic mice [J].2014,9(12):4). Asthma is a complex inflammatory disease characterized by airway hyperresponsiveness, airway inflammation and goblet cell mucus hypersecretion, accompanied by IL-4, IL-5, and IL-13 produced by cells in the lungs. inf...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/282A61K9/12A61K47/69A61P11/00A61P11/06A61P11/14
CPCA61K36/282A61K47/6951A61P11/06A61P11/14A61P11/00A61K9/0078A61K9/08
Inventor 徐霞荣影刘芳琳张俊伟张靖娴可钰陈迪屈凌波廖兴林蒋七熳
Owner ZHENGZHOU UNIV
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