57 results about "Granisetron" patented technology

Formulations and methods of manufacture are provided for granisetron dry powder compositions suitable for intranasal administration. Also provided are methods of use for preventing or controlling emesis and other diseases and disorders and devices, compositions, and methods for nasal delivery of therapeutic formulations. Devices for delivery of dry powder formulations are also provided. Devices can be single-use devices.

Compositions are provided for the intranasal administration of granisetron or a pharmaceutically acceptable salt thereof. Preferred compositions are in the form of an aqueous solution. Optionally, the compositions comprise chitosan, a salt or derivative thereof or a salt of a derivative of chitosan. The compositions can be used for the treatment or prevention of nausea and / or vomiting.

A disposable skin-worn device for the transdermal delivery at least one dose of charged therapeutic substances, including granisetron, by iontophoresis, the device comprising a donor reservoir containing an amount of a therapeutic substance to be delivered transdermally by iontophoresis, a counter reservoir, a source of electric power connected in a circuit between the donor reservoir and the counter reservoir and a control system for controlling current flow in the circuit to enable at least one dose of the therapeutic substance to be delivered transdermally by iontophoresis and wherein the control system includes a control element selected from the group consisting of a sensor activated by an external signal and a switch.

The invention relates to a Granisetron and / or a hydrochloride patch thereof, which comprises a lining layer, a medicine carrying pressure sensitive adhesive layer containing the Granisetron or / and the hydrochloride thereof, and an anti-sticking layer, wherein the medicine carrying pressure sensitive adhesive layer is characterized in that pressure sensitive adhesive contains carboxylic groups; the content of the Granisetron or / and the hydrochloride thereof in percentage by weight is 1%-12%; the medicine carrying pressure sensitive adhesive layer contains metal ions capable of enabling the pressure sensitive adhesive to generate cross linking, and the content of the metal ions in the medicine carrying pressure sensitive adhesive layer in percentage by weight is 0.05%-2%; and the medicine carrying pressure sensitive adhesive layer contains organic acids with 2-18 carbon atoms, and the molar ratio of the adding amount of the organic acids to the adding amount of the Granisetron or / and the hydrochloride thereof is (1-5):1. The patch of the invention can obviously increase the percutaneous infiltration capacity of the Granisetron and improve the solvent resistant and ageing resistant action of the substrate, can be applied to preventing and treating the symptoms of nausea, emesis and the like caused by radiotherapy, chemotherapy and operations, and has great foreseeable economic value and social value.

A synthesis method of intermediate 1-methylindole-3-carboxylic acid of a granisetron drug comprises the steps as follows: adding 130 ml of acrylonitrile and 0.32 mol of stannous chloride to a reaction vessel, controlling the stirring speed at 130 to 170 rpm, adding 0.053 mol of 1H-indazole-3-formic acid, increasing the temperature of the solution to 50-55 DEG C, preforming reflux for 5-6 h, slowly adding 0.061-0.063 mol of amine methane, performing reflux for 8-9 h, reducing the temperature of the solution to 5-9 DEG C, leaving the solution to stand for 30-32 h, separating a solid out, performing filtration, dissolving the solid in 150 ml of a potassium bromide solution, performing filtration, adding an oxalic acid solution to adjust the pH of the solution to 3-4, separating a solid out, performing suction filtration, performing washing with a saline solution and washing with nitromethane, performing dehydration with a dehydrating agent, and performing recrystallization in ethyl acetate to obtain 1-methylindole-3-carboxylic acid crystals; the saline solution in the step is any one of sodium sulfate and potassium nitrate.

The invention discloses a palonosetron injection and a preparation method thereof. The main components of the injection are: 0.01-0.05 mg / ml of palonosetron hydrochloride, 45-55 mg / ml of glucose, and 0.2-10 mg / ml of glycine. The preparation method of the injection comprises the following steps: (1) dissolving palonosetron hydrochloride, glucose, and glycine in an appropriate amount of water for injection, adjusting the pH value, and adding water for injection to the required amount; (2) dissolving the obtained The solution is filtered with a microporous membrane; (3) the aseptically filtered solution is subpackaged, filled with inert gas or carbon dioxide, plugged and capped. The palonosetron injection has low production cost and good stability.