1 results about "Granisetron" patented technology

The present application discloses a granisetron sustained-release microsphere and a preparation method therefor. On the basis of the mass of the granisetron sustained-release microspheres being 100%, the content of granisetron or a pharmaceutically acceptable salt thereof is 3-12%, the content of a stabilizer is 1-25%, and the content of a biodegradable polymer is 65-96%. The biodegradable polymer is a poly(lactic-co-glycolic acid), and the stabilizer is a fatty acid. The granisetron sustained-release microsphere obtained by the present invention has a high drug loading capacity, a uniform particle size, a complete morphology and no adhesion, a smooth surface without obvious pores, and no risk of burst release or drug leakage, and can achieve sustained release in vitro for up to 5-7 days.